Neurological Manifestations of COVID-19: A Series of Seven Cases

Goel, Kavya; Kumar, Amit; Diwan, Sahil; Kohli, Santvana; Sachdeva, Harish C; Usha, G; Mustafi, Saurav Mitra; Kumar, Pravin

doi:10.5005/jp-journals-10071-23723

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…Filosto et al [14] published a series of 34 GBS cases in the North Italian population of 8.4 million, and calculated a rate of 47.9 cases of GBS per 100 000 COVID-19 infections. In a prior case series published by our hospital (Goel et al [15]), we have also reported neurological manifestations of COVID-19 disease presenting to our hospital, out of which 2 presented with GBS.…”

Section: Discussionsupporting

confidence: 51%

Guillain-Barré Syndrome after COVID-19 Vaccine: Should We Assume a Causal Link?

Kohli

Varshney

Mangla

et al. 2021

IJMPCR

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The virus SARS-CoV2 and the disease spectrum caused by it have led to a widespread impact on the medical and economic status of all nations of the world. This led to an expedited mission to introduce a vaccine which could attempt to neutralize the pandemic to some extent. Many vaccines have been introduced with an acceptable safety profile, producing only mild adverse effects of soreness at injection site, malaise, fever, diarrhoea, myalgia and uncommonly allergic/anaphylactic reactions and possibility of getting infected with SARS-CoV2. Some isolated reports have also emerged of serious thromboembolic phenomena and neurological complications such as Guillain-Barré Syndrome (GBS). A similar incident was noticed at our institute, where a 71 year old male recipient of COVID-19 vaccine at an immunization centre, presented to us with features of GBS. We hereby report this case, not establishing a direct link between the two, but to raise awareness regarding the ongoing mass immunization world-wide.

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Section: Discussionsupporting

confidence: 51%

Guillain-Barré Syndrome after COVID-19 Vaccine: Should We Assume a Causal Link?

Kohli

Varshney

Mangla

et al. 2021

IJMPCR

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“…On the opposite side, Goel et al [ 11 ] proved that the most commonly reported COVID neurological complications are cerebrovascular accidents, encephalopathy, encephalitis, meningitis, and Guillain-Barr e syndrome (GBS).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 neurological manifestations: correlation of cerebral MRI imaging and lung imaging—Observational study

Saleh

Shaban

2021

Egypt J Radiol Nucl Med

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Background During the current pandemic, there is an increased incidence of neurologic/neuropsychiatric manifestations in patients with the novel coronavirus (COVID-19). Neurologic manifestations may be coincident or result of disease and its therapy. In the emergency department, orientation of the clinician with this issue is crucial for accurate decision making to limit the spread of infection during neurologic treatment. This study aimed to be familiar with MRI findings in patients with Neuro-COVID. Seventy patients presented with neurologic/neuropsychiatric manifestation either post COVID or during hospitalization underwent cerebral MRI from April 2020 to June 2021 (39 men and 31women; mean age 43.27, age range from 16 to 69 years). Results Headache (80%), is the most prevalent neurological manifestations followed by smell and taste impairment (62.9%) and stroke symptoms (45.7%). Low mood and anxiety (17.1%), prolonged fatigue (14.3%) and depression (7.1%) are the most common psychiatric symptoms. Infarctions, hematoma and demyelinating disease are the most prevalent findings. There is a week positive correlation between MRI findings and CT chest finding but without statistical significance (P-value 0.2). Conclusions Cerebrovascular disease and demyelinating lesions are common manifestations of COVID 19. Familiarity of neurologists and radiologist in the emergency department and in-patient with this issue is crucial to avoid misdiagnosis and the spread of infection.

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“…A diagnosis of COVID-19 neurological manifestations requires the exclusion of alternate etiologies, including sepsis, metabolic, autoimmune, or critical illness neuropathy. Sepsis alone can result in encephalopathy or polyneuropathy in 70% of patients [2]. Critical illness neuropathy is a sensorimotor polyneuropathy that is often a complication of sepsis and multiorgan failure, occurring in 70% of such patients [3].…”

Section: Discussionmentioning

confidence: 99%

“…The novel coronavirus SARS-CoV-2 is commonly known to affect the respiratory system, but other organ systems, including the nervous system, can become dysfunctional as a result of severe illness. Central nervous system (CNS) manifestations like stroke, seizures, venous sinus thrombosis, meningitis, encephalitis, myelitis, and CNS vasculitis, and peripheral nervous system (PNS) manifestations like Guillain-Barre syndrome (GBS) and myopathy have been reported with COVID-19 infection [1,2]. Even with these known complications associated with severe COVID-19 infection, it is often difficult to distinguish whether the neurological features are manifestations of critical illness or specific to the virus itself.…”

Section: Introductionmentioning

confidence: 99%

Post-COVID-19 Neurological Sequelae of Polyneuropathy and Encephalitis: A Comprehensive Case Report

Manuel,

Sapone,

Lin

et al. 2024

Cureus

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, commonly known as COVID-19, has been associated with various neurological complications. However, the mechanisms underlying these neurological manifestations remain incompletely understood. We present a case of a 63-year-old male who was admitted to the intensive care unit with severe COVID-19 pneumonia. Following recovery from respiratory symptoms, he was found to have weakness in the limbs. Months later, he also developed altered mental status, hallucinations, and behavioral changes. Neurological examination revealed signs consistent with polyneuropathy and autoimmune encephalitis. Further investigations, including nerve conduction studies, cerebrospinal fluid analysis, and response to steroids, supported the diagnosis of COVID-19-related polyneuropathy and autoimmune encephalitis. This is a rare presentation of COVID-19 and has only been described in a few case reports. Further research is warranted to elucidate the pathophysiological mechanisms underlying neurological sequelae of COVID-19 and to develop targeted therapeutic strategies.

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Neurological Manifestations of COVID-19: A Series of Seven Cases

Cited by 11 publications

References 15 publications

Guillain-Barré Syndrome after COVID-19 Vaccine: Should We Assume a Causal Link?

Guillain-Barré Syndrome after COVID-19 Vaccine: Should We Assume a Causal Link?

COVID-19 neurological manifestations: correlation of cerebral MRI imaging and lung imaging—Observational study

Post-COVID-19 Neurological Sequelae of Polyneuropathy and Encephalitis: A Comprehensive Case Report

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