Neurological manifestations of dengue infection

Solomon, Tom; Dung, Nguyen Minh; Vaughn, David W.; Kneen, Rachel; Thao, Le Thi Thu; Raengsakulrach, Boonyos; Loan, Ha Thi; Day, Nicholas P. J.; Farrar, Jeremy; Myint, Khin Saw Aye; Warrell, Mary; James, William; Nisalak, A.; White, Nicholas J.

doi:10.1016/s0140-6736(00)02036-5

Cited by 523 publications

(530 citation statements)

References 23 publications

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“…Similar observations regarding neurological sequelae are noted in earlier reports. [7][8][9][10] Only three of the seven with neurological manifestations had shock that is similar to the observations of Kamath and Ranjit. [8] The total mortality among the treated patients was one with a case fatality rate of <1%.…”

Section: Discussionsupporting

confidence: 87%

Dengue epidemic management in a developing country

Nair¹,

Sanjeev²,

Mishra³

2015

Int J Med Public Health

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Context: Dengue epidemic causes a wide spectrum of illness ranging from mild asymptomatic illness to severe fatal dengue. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with a sharp increase in the size of the human population at risk. Aims: Use of the WHO criteria (2012) for triage of dengue patients in an epidemic in a developing country with resource crunch of trained manpower and infrastructure. Settings and Design: The study was a retrospective and descriptive study carried out in a tertiary center in New Delhi, India during the dengue epidemic of 2013. Materials and Methods: Triage of dengue cases were done in an outpatient department setting as per latest WHO guidelines 2012 and only those cases with danger signs or severe dengue were admitted. A combination of serological studies involving nonstructural protein 1 antigen, IgM and IgG antibodies were used for diagnosis. Statistical Analysis Used: Statistical analysis was done by SPSS version 19 and P < 0.05 was considered signifi cant. Results: We studied the clinical, biochemical and serological profi le of the inpatients retrospectively. Active participation of parents has to be utilized to augment the monitoring of patients in a developing country with manpower and infrastructure resources crunch. Conclusion: In a developing country like India, with an ever exploding population, an epidemic of dengue causes a severe manpower and resources' crunch. Use of the WHO criteria for triage of dengue patients in an epidemic can help in effective management of dengue cases in an epidemic situation.

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Section: Discussionsupporting

confidence: 87%

Dengue epidemic management in a developing country

Nair¹,

Sanjeev²,

Mishra³

2015

Int J Med Public Health

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show abstract

“…Because DENV infections in the CNS and the associated neurological manifestations are possibly misdiagnosed in Brazil (e.g., meningoencephalitis and encephalitis), this report serves as an alert regarding the importance of DENV diagnosis in CNS infections. Furthermore, because this viral pathogen is not identifi ed in most cases of CNS viral infection in Brazil, the number of cases and impact on public health might be more important than suspected, and the number of dengue infections in the CNS might be underestimated (2) (10) . Finally, this study provides new information regarding the symptoms and signs of dengue infection in the CNS with neurological manifestations and an update to the DENV-3 genotype I epidemiology in Brazil.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, previous studies have demonstrated an important feature of DENV-3 genotype I, which is its ability to cause CNS infection and modulate the immunological system in a mouse model that was intracranially inoculated (8) (9) .Neurological manifestations of dengue infection in humans range from a common headache to more severe symptoms, such as nuchal rigidity, reduced consciousness, and convulsions. Moreover, some cases can experience severe encephalopathy, which can lead to sequelae (10) .…”

mentioning

confidence: 99%

Infection of the central nervous system with dengue virus 3 genotype I causing neurological manifestations in Brazil

Oliveira

Machado

Almeida

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…Neurological manifestations are rare in DHF and were seen in 1% cases in a study done in Vietnam [2]. These include mononeuropathies, polyneuropathies, Guillain-Barre syndrome and transverse myelitis.…”

Section: Discussionmentioning

confidence: 98%