2004
DOI: 10.1016/j.jnutbio.2004.05.002
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Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

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Cited by 447 publications
(261 citation statements)
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References 116 publications
(123 reference statements)
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“…Green tea, one of the world's most widely consumed beverages, contains a number of these biologically active polyphenolic compounds, suggesting that the active components of green tea may be beneficial and neuroprotective in conditions of increased oxidative load. Recent studies have demonstrated the neuroprotective activity of GTP in animal models of neurodegenerative conditions such as Parkinson's and Alzheimer's disease and their ability to markedly reduce hypoxic-ischemic tissue loss in models of ischemic stroke through inhibition of caspase-3 activation and proteolytic cleavage of its substrates (31)(32)(33)(34). Although the potential mechanisms whereby GTP may prevent neurological deficits remain to be fully elucidated, recent evidence suggests that GTP may operate as potent free oxygen radical scavengers and protect the brain and other Relative prostaglandin E 2 (PGE 2 ) production in the hippocampal CA1 region of rats exposed to room air (RA) or intermittent hypoxia (IH) and treated with green tea polyphenols (GTP) or vehicle (n 5 3 per group; *P , 0.05, # P , 0.05 vs. RA).…”
Section: Discussionmentioning
confidence: 99%
“…Green tea, one of the world's most widely consumed beverages, contains a number of these biologically active polyphenolic compounds, suggesting that the active components of green tea may be beneficial and neuroprotective in conditions of increased oxidative load. Recent studies have demonstrated the neuroprotective activity of GTP in animal models of neurodegenerative conditions such as Parkinson's and Alzheimer's disease and their ability to markedly reduce hypoxic-ischemic tissue loss in models of ischemic stroke through inhibition of caspase-3 activation and proteolytic cleavage of its substrates (31)(32)(33)(34). Although the potential mechanisms whereby GTP may prevent neurological deficits remain to be fully elucidated, recent evidence suggests that GTP may operate as potent free oxygen radical scavengers and protect the brain and other Relative prostaglandin E 2 (PGE 2 ) production in the hippocampal CA1 region of rats exposed to room air (RA) or intermittent hypoxia (IH) and treated with green tea polyphenols (GTP) or vehicle (n 5 3 per group; *P , 0.05, # P , 0.05 vs. RA).…”
Section: Discussionmentioning
confidence: 99%
“…[1][2][3][4] Furthermore, green tea polyphenols (GTPs) have been implicated as neuroprotective agents in diseases such as Alzheimer's and Parkinson's through the reduction of iron accumulation, reactive oxygen species (ROS), and inflammation. 3,6 Being regarded as a functional food and broad-spectrum botanical, green tea appears to impact various biological processes that may contribute to a reduction in the rates of aging and age-associated diseases. 3,6 Previous reports have found green tea to extend the lifespan of various animal models.…”
Section: Introductionmentioning
confidence: 99%
“…3,6 Being regarded as a functional food and broad-spectrum botanical, green tea appears to impact various biological processes that may contribute to a reduction in the rates of aging and age-associated diseases. 3,6 Previous reports have found green tea to extend the lifespan of various animal models. In Caenorhabditis elegans, daily administration of 220 lM of EGCG, its most prevalent and active flavonoid, increased the mean lifespan up to 14%.…”
Section: Introductionmentioning
confidence: 99%
“…Iron accumulation occurs in specific areas of the brain where degeneration occurs, in both PKD and AD (Riederer et al, 1989). In AD, the free iron pool leads to neocortical amyloid β peptide (Aβ) deposition, the hyperphosphorylation of tau (PHF-τ, a major component of neurofibrillary tangles) and tangle formation (Weinreb et al, 2004).…”
Section: Neurodegenerative Disordersmentioning
confidence: 99%