Neurological presentations caused by <i>Rickettsia felis</i> infection

Ye, Gongjie; Yang, Lei; Xu, Liang; Pan, Zhentao; Dong, Zhouzhou

doi:10.12968/hmed.2021.0212

Cited by 8 publications

(6 citation statements)

References 3 publications

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“…Originally identified as a flea endosymbiont, it was later incriminated as the causal agent of a febrile illness in patients from North America and Southeast Asia (Ye et al., 2021). Particularly, in Mexico, it was identified as a potential causative agent of pleuritis and hepatomegaly (Pérez‐Osorio et al., 2008).…”

Section: Introductionmentioning

confidence: 99%

Is vertical transmission the only pathway for Rickettsia felis ?

Colunga‐Salas

Sánchez‐Montes

Torres–Castro

et al. 2022

Transbounding Emerging Dis

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The genus Rickettsia encompasses several species grouped into two main clusters, Typhus and the Transitional groups. The latter group contains Rickettsia felis, an endosymbiont of several arthropods with an uncertain human pathogenicity and whose most efficient transmission mechanism described thus far is transovarial. The aim of this study was to evaluate whether this pathway exists using phylogenetic analysis and partial sequences of the 17kDa and gltA genes and comparing them with host phylogeny using the cytb region. This is the first study that evaluates the vertical transmission of R. felis. In general, both phylogenies of R. felis showed no polytomies, as suspected if this pathway was the only pathway occurring. When phylogenies of the invertebrates and the gltA of R. felis were compared for strong coevolutionary insight, intricate relationships were observed, suggesting that other transmission pathways must occur, such as horizontal transmission. Further studies are needed to determine which other transmission routes occur in hematophagous arthropods.

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Section: Introductionmentioning

confidence: 99%

Is vertical transmission the only pathway for Rickettsia felis ?

Colunga‐Salas

Sánchez‐Montes

Torres–Castro

et al. 2022

Transbounding Emerging Dis

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“…In this work, it was possible to detect and typify, for the first time, Rickettsia felis (a species belonging to the group previously called transitional, now known as SFG‐1 (El Karkouri et al, 2022)) in samples of O. puertoricensis . In the southeast state of Yucatan, Mexico, as well as in Peru, the US and several African countries, R. felis is the cause of an emerging neglected febrile illness, called flea‐borne spotted fever (cat flea typhus) (Ye et al, 2021). It has been demonstrated that serological assays in humans identified cross‐reactivity between R. felis and R. typhi (the etiological agent of murine typhus), preventing a definitive diagnosis (Teoh et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…In the Nearctic region, Ornithodoros hermsi Wheeler, Herms and Meyer, and Ornithodoros turicata Dugès were infected by the tick‐borne relapsing fever spirochetes Borrelia hermsii (Davis) and Borrelia turicatae (Brumpt), respectively (Schwan, 2021). Additionally, Ornithodoros capensis Neumann was recorded associated with the emerging pathogen Rickettsia felis Bouyer, Stenos, Crocquet‐Valdes, Moron, Popov, Zavala‐Velazquez, Foil, Stothard, Azad, and Walker, a member of the spotted fever group causing flea‐borne spotted fever (cat flea typhus) (Reeves et al, 2006; Ye et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Confirmation of the presence of Rickettsia felis infecting Ornithodoros puertoricensis in Mexico

Ballados‐González

Bravo‐Ramos

Grostieta

et al. 2022

Medical Vet Entomology

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Soft ticks are neglected competent vectors of a wide range of pathogenic microorganisms, among which bacteria of the genera Rickettsia and Borrelia stand out. In Mexico, previous studies have shown the presence of a member of the Ornithodoros talaje complex in the Virginia opossum (Didelphis virginiana Didelphimorphia: Didelphidae Kerr) from southeastern Mexico. However, its specific identification has not been achieved. Two D. virginiana were treated in a private clinic during the period of April–May 2022. Tick larvae were manually removed, DNA extraction was performed, and some genes from various bacterial and parasitic pathogens were amplified and sequenced. A total of 96 larvae were recovered, which were morphologically identified as Ornithodoros puertoricensis (Ixodida: Argasidae Fox); the 16 S sequences showed a similarity of 96.79%–99.51% with sequences of O. puertoricensis from Panama and Colombia. The presence of Rickettsia felis (Rickettsiales: Rickettsiaceae Bouyer et al.) was detected in 15 specimens from one host. The soft tick O. puertoricensis is recorded for the first time as an ectoparasite of the Virginia opossum in America and represents the second report for this soft tick in Mexico since 1963. This represents the most northern record of this tick species in its geographic distribution and brings a new soft tick‐Rickettsia association.

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“…The first R. felis infection case in China was reported in Jiangsu Province via PCR analysis in 2014 (Zhang et al, 2014). More cases of rickettsial disease have been diagnosed in recent years owing to the development and application of high-throughput sequencing, and these include five R. felis infections in mainland China (Yang X. S. et al, 2021;Ye et al, 2021;Zeng et al, 2021;Zhang et al, 2021;Cheng et al, 2022) (Figure 1). These were sporadic cases distributed across several provinces (Shanxi, Zhejiang, and Fujian).…”

Section: Introductionmentioning

confidence: 99%

Human Rickettsia felis infections in Mainland China

Teng

Zhao

Ren

et al. 2022

Front. Cell. Infect. Microbiol.

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We identified four flea-borne spotted fever cases caused by Rickettsia felis in a retrospective survey of 182 patients with fever of unknown origin (FUO) in China between 2021 and 2022. The clinical signs and symptoms of the patients were similar to those of other rickettsioses, including fever, rash, and liver and kidney dysfunction. All four patients in the present study developed pneumonia or lung lesions after R. felis infection. The cases of R. felis infection, a neglected infectious disease, were sporadic in multiple provinces of the country. The high prevalence (2.14%, 4/187) of R. felis among patients with FUO highlights the risk posed by this pathogen to public health in China.

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Neurological presentations caused by Rickettsia felis infection

Cited by 8 publications

References 3 publications

Is vertical transmission the only pathway for Rickettsia felis ?

Is vertical transmission the only pathway for Rickettsia felis ?

Confirmation of the presence of Rickettsia felis infecting Ornithodoros puertoricensis in Mexico

Human Rickettsia felis infections in Mainland China

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