Neurological presentations revealing acquired copper deficiency: diagnosis features, aetiologies and evolution in seven patients

Poujois, Aurélia; Djebrani‐Oussedik, Nouzha; Ory‐Magne, Fabienne

doi:10.1111/imj.13650

Cited by 12 publications

(25 citation statements)

References 19 publications

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“…Performance of the radiocopper test was comparable to 24‐hours urinary copper excretion and much better than those of serum ceruloplasmin and total copper. Although the diagnostic value of 24‐hours urinary copper output was high in our study, perturbed copper excretion may be observed in other circumstances (eg, because of liver failure of any origin or chronic zinc intake) and problems with urine collection can cause difficulties in diagnosis . Interestingly, we also confirmed the low diagnostic value of NCC, which is not recommended as a diagnostic tool .…”

Section: Discussionsupporting

confidence: 45%

Accuracy of the radioactive copper incorporation test in the diagnosis of Wilson disease

Członkowska

Rodo

Wierzchowska-Ciok

et al. 2018

Liver International

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Section: Discussionsupporting

confidence: 45%

Accuracy of the radioactive copper incorporation test in the diagnosis of Wilson disease

Członkowska

Rodo

Wierzchowska-Ciok

et al. 2018

Liver International

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“…A new deficiency in copper was seen in one study; a deficiency of such micronutrients may cause peripheral neuropathy 40 and indirectly contribute to OI. However, copper deficiency is known to cause myelopathy more than peripheral neuropathy 41 . In the included studies, pathophysiological changes after BS were not favouring inducing OI except for the study of meal volume and posture, 31 which might reflect a dumping syndrome phenomenon 42 …”

Section: Discussionmentioning

confidence: 99%

Orthostatic intolerance after bariatric surgery: A systematic review and meta‐analysis

et al. 2021

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Summary There have been increased reports of orthostatic intolerance post‐bariatric surgery. However, the prevalence, pathophysiology and long‐term outcomes have not been well described. Therefore, we sought to summarize evidence of orthostatic intolerance after bariatric surgery. We conducted a systematic review using PubMed, Scopus, CINAHL, Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify relevant articles from the date of inception until 1st April 2020. Study selection, data extraction and quality assessment of the included studies were performed independently by two reviewers. The findings of the included studies were narratively reported. When feasible, a meta‐analysis was done to summarize the relevant results. We included 20 studies (n = 19 843 participants) reporting findings of 12 prospective cohort studies, 5 retrospective cohort studies, 2 cross‐sectional studies and one randomized controlled trial. The 5‐year cumulative incidence of orthostatic intolerance was 4.2% (one study). Common clinical presentations of orthostatic intolerance were lightheadedness, dizziness, syncope and palpitation. The pooled data suggested improvement in overall cardiac autonomic function (sympathetic and parasympathetic) post‐bariatric surgery. In addition, a significant systolic blood pressure drop may reflect a reset of the balance between the sympathetic and parasympathetic nervous systems after weight loss in the pooled analysis. Existing literature on orthostatic intolerance post‐bariatric surgeries was limited or of low quality, and larger studies are needed to know the true incidence of orthostatic intolerance post‐bariatric surgeries and the pathophysiology. We found one study reporting the 5‐years cumulative incidence of orthostatic intolerance post‐bariatric surgeries as only 4.2%. This could challenge the idea of increased orthostatic intolerance prevalence post‐bariatric surgeries. Registration The review protocol was registered at the International Prospective Register of Systemic Reviews PROSPERO (CRD42020170877).

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“…Cytoplasmic vacuolization within erythroid and myeloid precursors are unique to copper deficiency, and can help distinguish between these two conditions 72 . Neurologic involvement often takes the form of progressive spastic‐ataxic gait due to myelopathy which is very similar to subacute combined degeneration 73,74 . Other neurologic features include myeloneuropathy, optic neuropathy, and motor neuron disease.…”

Section: Disorders Of White Blood Cellsmentioning

confidence: 99%

Movement Disorders and Hematologic Diseases

Patel

Hall

Eichenseer

et al. 2020

Movement Disord Clin Pract

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BackgroundMovement disorders can be associated with or caused by hematological abnormalities. The objective of this review is to highlight features that will aid in the clinician's recognition and treatment of these disorders.MethodsMESH terms relevant to movement disorders and hematologic diseases were searched to identify conditions included in this narrative, educational review.ResultsSeveral conditions were identified, and they were organized by hematologic categories to include red blood cell abnormalities, white blood cell abnormalities, disorders of clotting and bleeding, hematologic malignancies, and others.ConclusionsThis review will increase providers’ understanding of disorders that include movement disorders and hematologic abnormalities. Basic hematologic laboratories can aid in assessment of these disorders, to include complete blood count/hemogram and peripheral blood smear. Recognition is key, especially in the setting of underlying malignancy, vitamin deficiency, or other disorder in which treatment is available.

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Neurological presentations revealing acquired copper deficiency: diagnosis features, aetiologies and evolution in seven patients

Abstract: Progressive PCS with anaemia and lymphopenia must raise the possibility of an ACD. Early copper supplementation could increase the neurological prognosis.

Cited by 12 publications

References 19 publications

Accuracy of the radioactive copper incorporation test in the diagnosis of Wilson disease

Accuracy of the radioactive copper incorporation test in the diagnosis of Wilson disease

Orthostatic intolerance after bariatric surgery: A systematic review and meta‐analysis

Movement Disorders and Hematologic Diseases

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