Neurological sequelae in children born after in-vitro fertilisation: a population-based study

Strömberg, Bo; Dahlquist, Gisela; Ericson, Anders; Finnström, Orvar; Köster, Max; Stjernqvist, Karin

doi:10.1016/s0140-6736(02)07674-2

Cited by 501 publications

(234 citation statements)

References 19 publications

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“…The authors demonstrated that IVF children (singletons and multiple births taken together) had a threefold increased risk of CP until the age of 2 years, compared with control children. However, an increased risk for CP among IVF singletons was not observed as in some corresponding studies (21,32). The authors suggested that increased risk for CP in their study could be mainly explained by multiplicity.…”

Section: Scientific Journal Of the Faculty Of Medicine Inmentioning

confidence: 50%

“…On the other hand, with both multiplicity and preterm delivery included in the multivariate models, preterm delivery still remained strongly associated with the risk of CP. However, the increased risk of CP for IVF children was still lower than the risk found by Strömberg et al (21). The results showed that the risk for CP for term IVF singletons was HRR 0.84 (95% CI: 0.43-1.63), and for term IVF twins was HRR 0.83 (95% CI: 0.27-2.61).…”

Section: Scientific Journal Of the Faculty Of Medicine Inmentioning

confidence: 63%

“…An increased risk of developing CP in children born after IVF compared to matched controls was demonstrated in a population-based retrospective cohort study from Sweden (21). A total of 5.680 children (3.228 singletons, 2.060 twins, 367 triplets, and 25 quadruplets) born after IVF between 1982 and 1995 were included.…”

Section: Scientific Journal Of the Faculty Of Medicine Inmentioning

confidence: 99%

“…Most of the available findings suggest that there is a higher overall risk of CP in the population of children born after ART due to multiple births, preterm (<37 weeks of gestation) and very preterm (<32 weeks of gestation) delivery, low (<2500 g) or very low birth weight (<1500 g) (16)(17)(18)(19)(20). Also, these risk factors are strongly associated with numerous long-term health consequences, admission to neonatal intensive care units and prolonged hospitalization (11,(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Assessing the Risk of Cerebral Palsy in Children Born after Assisted Conception – The Role of Multiple Pregnancy and Preterm Delivery / Procena rizika od cerebralne paralize kod dece začete vantelesnim oplođenjem – uloga višestruke trudnoće i prevremenog rođenja

Milićević¹,

Potić²

2015

Acta Facultatis Medicae Naissensis

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For more than three decades, assisted reproductive techniques (ART) have been used as effective treatments to overcome infertility. Since then, numerous studies have been focused on different aspects of long-term health and development of children born after assisted conception. The aim of this paper is to summarize new data on multiple pregnancy and preterm delivery as one of the risk factors which might increase the risk of developing cerebral palsy (CP) in children born after assisted conception.A comprehensive search of eight databases retrieved 108 papers, 10 of which met inclusion criteria and were relevant for this review.Despite the dissimilarities in methodological and analytic approaches in the selected studies, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are generally considered safe, still there is an ongoing discussion whether multiple pregnancy and preterm delivery increase or do not increase the risk of CP in children born after assisted conception.All information about possible adverse maternal and/or infant outcomes should be made available to the couples seeking ART treatment.

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Section: Scientific Journal Of the Faculty Of Medicine Inmentioning

confidence: 50%

Section: Scientific Journal Of the Faculty Of Medicine Inmentioning

confidence: 63%

Section: Scientific Journal Of the Faculty Of Medicine Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessing the Risk of Cerebral Palsy in Children Born after Assisted Conception – The Role of Multiple Pregnancy and Preterm Delivery / Procena rizika od cerebralne paralize kod dece začete vantelesnim oplođenjem – uloga višestruke trudnoće i prevremenog rođenja

Milićević¹,

Potić²

2015

Acta Facultatis Medicae Naissensis

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“…Une étude anglaise très rigoureuse [3] a été menée sur des enfants âgés de deux ans, 208 nés après ICSI et 221 nés sans AMP ; tous ces enfants ont été examinés par le même pédiatre et des informations périnatales et sociodémographiques ont été collectées : les résultats recueillis montrent que les enfants ICSI ne sont pas différents des enfants conçus naturellement. Les séquelles neurologiques des enfants nés après AMP entre 1982 et 1995 ont été recherchées dans une étude suédoise [20] qui a comparé 5 680 enfants AMP, âgés de 18 mois à 14 ans, à 11360 enfants conçus naturellement. La différence éventuelle entre FIV et ICSI n'a pas été mesurée.…”

Section: Développement Psychomoteur Et Mentalunclassified

Les enfants de l’ICSI sous la loupe

2004

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Cerebral Palsy, Autism Spectrum Disorders, and Developmental Delay in Children Born After Assisted Conception

Hvidtjørn¹,

Schieve²,

Schendel³

et al. 2009

Arch Pediatr Adolesc Med

139

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To assess the existing evidence of associations between assisted conception and cerebral palsy (CP), autism spectrum disorders (ASD), and developmental delay. Data Sources: Forty-one studies identified in a systematical PubMed and Excerpta Medica Database (EMBASE) search for articles published from January 1, 1996, to April 1, 2008. Study Selection: Studies written in English comparing children born after assisted conception with children born after natural conception assessing CP, ASD, and developmental delay, based on original data with a follow-up of 1 year or more. Main Exposures: In vitro fertilization (IVF) with or without intracytoplasmic sperm injection or ovulation induction with or without subsequent intrauterine insemination. Main Outcome Measures: Cerebral palsy, ASD, and developmental delay. Results: Nine CP studies showed that children born after IVF had an increased risk of CP associated with preterm delivery. In our meta-analysis including 19 462 children exposed to IVF, we estimated a crude odds ratio of 2.18 (95% confidence interval, 1.71-2.77). Eight ASD studies and 30 studies on developmental delay showed inconsistent results. No studies assessed the risk of CP, ASD, or developmental delay in children born after ovulation induction exclusively.

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Neurological sequelae in children born after in-vitro fertilisation: a population-based study

Cited by 501 publications

References 19 publications

Assessing the Risk of Cerebral Palsy in Children Born after Assisted Conception – The Role of Multiple Pregnancy and Preterm Delivery / Procena rizika od cerebralne paralize kod dece začete vantelesnim oplođenjem – uloga višestruke trudnoće i prevremenog rođenja

Assessing the Risk of Cerebral Palsy in Children Born after Assisted Conception – The Role of Multiple Pregnancy and Preterm Delivery / Procena rizika od cerebralne paralize kod dece začete vantelesnim oplođenjem – uloga višestruke trudnoće i prevremenog rođenja

Les enfants de l’ICSI sous la loupe

Cerebral Palsy, Autism Spectrum Disorders, and Developmental Delay in Children Born After Assisted Conception

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