Neurological sequelae in newborn babies after perinatal asphyxia.

Souza, S W De; Richards, Ben

doi:10.1136/adc.53.7.564

Cited by 65 publications

(5 citation statements)

References 12 publications

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“…Autopsy was performed in 9 of the 15 babies who died and the findings were divers ranging from two with hyaline membrane disease, amniotic fluid aspiration, meconium aspiration, and subarachnoid haemorrhage. Most deaths occurred within the first 24 hours of life, a finding similar to that of several other researchers (16,25).…”

Section: Immediate (≤48 Hours) Outcome Of Babies With Lowsupporting

confidence: 89%

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Immediate outcome of babies with low Apgar score in Mulago Hospital, Uganda

Ondoa-Onama¹,

Tumwine²

2004

E Af Med Jrnl

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, hypoglycaemia, hypothermia, hypotension and hypoxaemia. Results: The prevalence of low Apgar score at one and five minutes was 8.4% and 2.8% respectively. Adverse outcome was seen in 57.3% of cases: death in 12.1% and clinical complications in 45.2%. HIE occurred in 21.8%, hypoxaemia in 12.9%, hypoglycaemia in 16.9% and aspiration pneumonia in 4.8%. Maternal factors significantly associated with low Apgar scores included primiparity, abnormal delivery, age and medical diseases during pregnancy, while birth injuries and cord accidents were the baby factors. Poor outcome was associated with birth injury, hypothermia, hypoglycaemia, hypotension, aspiration pneumonia, hypoxaemia and severe birth asphyxia. Conclusion: Even though the prevalence of low Apgar was only 8.4%, adverse outcomes associated with it were observed in more than half the patients. Therefore there is need to carefully evaluate and monitor babies with low Apgar scores immediately after birth.

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Section: Immediate (≤48 Hours) Outcome Of Babies With Lowsupporting

confidence: 89%

“…Previous studies have documented similar findings (17,24). Cardiovascular complications such as hypotension and bradycardia were present as have been observed by other workers (25,26).…”

Section: Immediate (≤48 Hours) Outcome Of Babies With Lowsupporting

confidence: 86%

Immediate outcome of babies with low Apgar score in Mulago Hospital, Uganda

Ondoa-Onama¹,

Tumwine²

2004

E Af Med Jrnl

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“…2 12 17 18 Had we failed to make this distinction we would have concluded that caesarean section had no effect on the risk of newborn encephalopathy. When we applied the eligibility criteria for elective sections we found that eligible case infants were more than 20 times less likely to be delivered by elective section than eligible control infants.…”

Section: Discussionmentioning

confidence: 99%

Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study

Badawi¹,

Kurinczuk²,

Keogh³

et al. 1998

BMJ

592

390

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Objective To identify intrapartum predictors of newborn encephalopathy in term infants. Design Population based, unmatched case-control study. Setting Metropolitan area of Western Australia, June 1993 to September 1995. Subjects All 164 term infants with moderate or severe newborn encephalopathy; 400 randomly selected controls. Main outcome measures Adjusted odds ratio estimates. Results The birth prevalence of moderate or severe newborn encephalopathy was 3.8/1000 term live births. The neonatal fatality was 9.1%. Maternal pyrexia (odds ratio 3.82), a persistent occipitoposterior position (4.29), and an acute intrapartum event (4.44) were all risk factors for newborn encephalopathy. More case infants than control infants were induced (41.5% and 30.5%, respectively) and fewer case infants were delivered by caesarean section without labour (3.7% and 14.5%, respectively). Operative vaginal delivery (2.34) and emergency caesarean section (2.17) were both associated with an increased risk. There was an inverse relation between elective caesarean section (0.17) and newborn encephalopathy. After application of a set of consensus criteria for elective caesarean section only three (7%) eligible case mothers compared with 33 (65%) eligible control mothers were sectioned electively. Of all the case infants, 113 (69%) had only antepartum risk factors for newborn encephalopathy identified; 39 (24%) had antepartum and intrapartum factors; eight (5%) had only intrapartum factors; and four (2%) had no recognised antepartum or intrapartum factors. Conclusions The causes of newborn encephalopathy are heterogeneous and many relate to the antepartum period. Elective caesarean section has an inverse association with newborn encephalopathy. Intrapartum hypoxia alone accounts for only a small proportion of newborn encephalopathy. These results question the view that most risk factors for newborn encephalopathy lie in the intrapartum period.

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“…Studies also report more severe neurological signs in patients suffering severe HI compared to those with milder HI injury ( Robertson and Finer, 1985 ). Yet, many individuals who showed abnormal neurological signs at birth were normal at 2-year follow-up ( De Souza and Richards, 1978 ). Clinical features and outcomes of neonatal HI are summarized in Figure 1 .…”

Section: Introduction: Global Clinical Impact Of Neonatal Hypoxia Iscmentioning

confidence: 99%

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

Millar

Shi

Hoerder‐Suabedissen

et al. 2017

Front. Cell. Neurosci.

289

272

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Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment. Improved intensive care technology has increased survival without preventing neurological disorder, increasing morbidity throughout the adult population. Early preventative or neuroprotective interventions have the potential to rescue brain development in neonates, yet only one therapeutic intervention is currently licensed for use in developed countries. Recent investigations of the transient cortical layer known as subplate, especially regarding subplate’s secretory role, opens up a novel set of potential molecular modulators of neonatal HI injury. This review examines the biological mechanisms of human neonatal HI, discusses evidence for the relevance of subplate-secreted molecules to this condition, and evaluates available animal models. Neuroserpin, a neuronally released neuroprotective factor, is discussed as a case study for developing new potential pharmacological interventions for use post-ischaemic injury.

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Neurological sequelae in newborn babies after perinatal asphyxia.

Cited by 65 publications

References 12 publications

Immediate outcome of babies with low Apgar score in Mulago Hospital, Uganda

Immediate outcome of babies with low Apgar score in Mulago Hospital, Uganda

Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

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