Neurological Sequelae of Sepsis: I) Septic Encephalopathy

Ringer, Thomas

doi:10.2174/1874828701104010002

Cited by 10 publications

(14 citation statements)

References 48 publications

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“…SAE is characterized by alterations in mental status and motor activity that can range from inattention, disorientation and delirium to agitation, hypoactivity and coma [71,72] . Delirium is frequently the first manifestation of sepsis and often precedes organ failure [73,74] . SAE is reported to occur in up to 70% of septic patients (71).…”

Section: Sepsis Associated Encephalopathymentioning

confidence: 99%

Metabolic theory of septic shock

Pravda¹

2014

WJCCM

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Septic shock is a life threatening condition that can develop subsequent to infection. Mortality can reach as high as 80% with over 150000 deaths yearly in the United States alone. Septic shock causes progressive failure of vital homeostatic mechanisms culminating in immunosuppression, coagulopathy and microvascular dysfunction which can lead to refractory hypotension, organ failure and death. The hypermetabolic response that accompanies a systemic inflammatory reaction places high demands upon stored nutritional resources. A crucial element that can become depleted early during the progression to septic shock is glutathione. Glutathione is chiefly responsible for supplying reducing equivalents to neutralize hydrogen peroxide, a toxic oxidizing agent that is produced during normal metabolism. Without glutathione, hydrogen peroxide can rise to toxic levels in tissues and blood where it can cause severe oxidative injury to organs and to the microvasculature. Continued exposure can result in microvascular dysfunction, capillary leakage and septic shock. It is the aim of this paper to present evidence that elevated systemic levels of hydrogen peroxide are present in septic shock victims and that it significantly contributes to the development and progression of this frequently lethal condition.

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Section: Sepsis Associated Encephalopathymentioning

confidence: 99%

Metabolic theory of septic shock

Pravda¹

2014

WJCCM

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“…The current UK guidance is that lumbar puncture must be performed as soon as encephalitis is suspected 8. This is certainly true, but many elderly patients with delirium and fever have an associated septic encephalopathy that closely mirrors this picture 8 16. If we were to lumbar puncture all such patients where the source of infection was initially unclear, the proportion found to have abnormal CSF would undoubtedly be very low.…”

Section: Discussionmentioning

confidence: 99%

Herpes zoster ophthalmicus progressing to encephalitis: beware pain preceding the rash

2013

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We present a challenging case in which the dermatomal pain associated with herpes zoster ophthalmicus preceded the cutaneous rash by several days. It thus highlights the need to consider this diagnosis among the differentials for severe unilateral headache in the elderly. The patient unfortunately progressed to develop encephalitis, an uncommon but serious complication of zoster reactivation and a reminder that this remains an important cause of morbidity and mortality in the elderly population.

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“…12 Kejang juga dapat timbul pada ensefalopati septik, tetapi tidak umum, disfungsi saraf kranial dan lateralisasi jarang terjadi dan harus dapat menyingkirkan penyebab lain yang mungkin. 13,14 Prevalensi ensefelaopati sepsis pada berbagai studi adalah 9-71%. 5,6 Sejalan dengan penelitan ini, ditemukan gejala sepsis ensefalopati secara klinis pada sepsis hari ketiga sebanyak 20 (38,46 %) subyek.…”

Section: Pembahasanunclassified

S100B sebagai Prediktor Defisit Neurologi pada Anak dengan Sepsis

Wardhani

Bahtera

2020

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Latar belakang. Respon sepsis merupakan rantai kejadian yang kompleks, terdiri dari proses inflamasi dan anti inflamasi, reaksi humoral dan selular, dan abnormalitas hemodinamik. Komplikasi sepsis dapat terjadi di semua organ dengan manifestasi berupa kegagalan fungsi multiorgan, salah satunya adalah susunan saraf pusat. Biomarker S100B merupakan suatu pemeriksaan yang digunakan untuk mengetahui tingkat kerusakan neurologi dan prognosis pasien anak/bayi dengan kondisi kritis salah satunya adalah sepsisTujuan. Membuktikan bahwa kadar S100B dapat digunakan sebagai prediktor terjadinya defisit neurologi pada anak dengan sepsis.Metode. Penelitian kohort prospektif pada 52 pasien anak dengan sepsis yang dirawat di Bangsal Anak, HCU, PICU dan IGD RSUP Dr. Kariadi Semarang periode Januari 2019 sampai Juni 2019. Pasien dengan sepsis diambil sampel darah S100B untuk dinilai kemudian dilihat dalam waktu 3 hari ada atau tidaknya defisit neurologi. Perbedaan S100B antara kedua kelompok dianalisis dengan uji Independent T Test. Cut-off point serum S100B sebagai prediktor defisit neurologi ditentukan dengan menggunakan kurva ROC.Hasil. Sejumlah 52 anak sepsis diikutkan dalam penelitian. Terdapat 20 anak dengan defisit neurologi dan 32 anak tanpa defisit neurologi. Mean S100B dengan defisit neurologi adalah 0,44±0,24 μg/L dan tanpa defisit neurologi adalah 0,14±0,06 μg/L (95% CI 0,21-0,39, p<0,0001). Luas area di bawah kurva ROC 0,923, dengan cut-off point S100B 0,21 μg/L, RR 9,84 (95% CI 3,309 – 29,27; p<0,0001).Kesimpulan. S100B dapat digunakan sebagai prediktor defisit neurologi pada anak dengan sepsis.

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Neurological Sequelae of Sepsis: I) Septic Encephalopathy

Cited by 10 publications

References 48 publications

Metabolic theory of septic shock

Metabolic theory of septic shock

Herpes zoster ophthalmicus progressing to encephalitis: beware pain preceding the rash

S100B sebagai Prediktor Defisit Neurologi pada Anak dengan Sepsis

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