Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families

Gourion, David; Goldberger, Celine; Bourdel, Marie‐Chantal; Baylé, F.; Millet, Bruno; Olié, Jean‐Pierre; Krebs, Marie‐Odile

doi:10.1016/s0920-9964(02)00333-x

Cited by 58 publications

(40 citation statements)

References 26 publications

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“…These results may help clarify some unresolved issues within the MPA and schizophrenia literature. For example, regarding number of MPA items, a handful of recent studies have used expanded versions of the original Waldrop scale Gourion et al 2003;2004a). There is some uncertainty, however, as to the importance of these additional items, both in terms of etiological significance and discriminatory ability.…”

Section: Discussionmentioning

confidence: 99%

Minor physical anomalies in schizophrenia: A meta-analysis

Weinberg

Jenkins

Marazita

et al. 2007

Schizophrenia Research

112

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Numerous studies report an increased frequency of minor physical anomalies (MPAs) in schizophrenic individuals compared with controls. However, these studies vary considerably regarding the magnitude of the case-control disparity and the topographical distribution of the anomalies. A meta-analysis was carried out on the existing MPA literature in an effort to better understand the relationship between MPAs and schizophrenia. Following a literature search, 13 studies were identified that met our inclusion criteria. Mean total MPA scores were available for 11 of these studies, whereas only seven studies provided regional MPA scores. For both the total MPA and regional MPA analyses, pooled effect sizes (Hedges' g and pooled odds ratios, respectively) were calculated along with tests of heterogeneity. For the total MPA analyses, a meta-regression approach was used to explore the relationship between possible moderator variables (e.g., number of MPA scale items) and effect size heterogeneity. The magnitude of the pooled effect size for the total MPA scores was high (1.131; p < 0.001), indicating significantly more overall MPAs in schizophrenic individuals. Significant effect size heterogeneity was present (p < 0.001); however, this heterogeneity could not be explained by any of the included moderator variables. The regional MPA analysis revealed significantly increased MPAs in all six anatomical regions (p < 0.05), although the pooled odds ratios for these regions did not differ significantly from one another. These results suggest a lack of regional specificity for MPAs in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Minor physical anomalies in schizophrenia: A meta-analysis

Weinberg

Jenkins

Marazita

et al. 2007

Schizophrenia Research

112

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“…The prevalence rate of neurological signs among patients with schizophrenia ranges from 50% to 65% in contrast to 5% in healthy controls in western samples [20,21]. However, specifically for soft signs, the prevalence rate ranges from 9% to 82% as compared to 3% to 12.5% [22][23][24][25][26][27][28][29]. The only available data for Chinese patients with schizophrenia and healthy controls reveals that the prevalence rates in Chinese patients with schizophrenia and healthy controls are 59% and less than 5%, respectively [30].…”

Section: Illustration Of Neurological Soft Signs As An Example From Cmentioning

confidence: 99%

Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders

Chan

2011

Chin. Sci. Bull.

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Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in mainland China. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in mainland China. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium. endophenotypes, neurological soft signs, neuropsychiatric disorders, mental health, China Citation:Chan R C K. Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders.This strategic paper argues the need for establishing a central consortium for the endophenotype approach for neuropsychiatric disorders in mainland China. We start with a brief introduction to endophenotypes, what is known about the concept of endophenotypes, and then to illustrate the claim that endophenotypes are more important than traditional genetic approach of studying neuropsychiatric disorders. This is not our intention to provide a comprehensive review of all endophenotypes employed in neuropsychiatric disorders in this strategic paper because there are several systematic reviews on this aspect [1][2][3][4]. However, we would illustrate an example of a promising endophenotype, neurological soft signs, in detailing the steps for building the consortium.

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“…[10][11][12] Neurological soft signs have been found in high-risk individuals, monozygotic twins discordant for schizophrenia, and first-degree relatives, supporting their role as trait markers for schizophrenia. 9,13 Although findings regarding neurological soft signs in OCD are scarce compared with schizophrenia, some studies found an increased rate of neurological soft signs in patients with OCD compared with healthy subjects. 14-16 Several groups revealed soft signs in OCD patients that were comparable to those seen in schizophrenia, including deficits in motor speed and sequencing, suggestive of common frontal-subcortical dysfunction in both disorders.…”

Section: Neurological Soft Signs In Schizophrenia Patients With Ocdmentioning

confidence: 99%

Neurological Soft Signs in Schizophrenia Patients With Obsessive-Compulsive Disorder

Poyurovsky

Faragian²,

Pashinian³

et al. 2007

JNP

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Obsessive-compulsive disorder is a prevalent and clinically significant phenomenon in schizophrenia patients. Both schizophrenia and obsessive-compulsive disorder (OCD) are considered to be neurodevelopmental disorders sharing dysfunctional frontal-subcortical circuitry. Using the Neurological Evaluation Scale (NES), the authors assessed neurological soft signs in 59 patients who met DSM-IV criteria for both schizophrenia and OCD. The two schizophrenia groups (with and without OCD) scored higher than the comparison group but did not significantly differ from one another on any of the NES subscales. The first-episode patients in both groups scored similarly to patients with repeated hospitalizations on all NES subscales. Notably, the OCD patients scored similarly to the two schizophrenia groups on the NES motor sequencing subscale. The author's findings support the notion that neurological soft signs are independent markers of brain dysfunction detectable early in the course of schizophrenia. However, they are of limited value as a putative endophenotype in a search for specific etiological mechanisms underlying a schizo-obsessive subgroup of schizophrenia.

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Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families

Cited by 58 publications

References 26 publications

Minor physical anomalies in schizophrenia: A meta-analysis

Minor physical anomalies in schizophrenia: A meta-analysis

Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in mainland China: An example from neurological soft signs for neuropsychiatric disorders

Neurological Soft Signs in Schizophrenia Patients With Obsessive-Compulsive Disorder

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