Neurological soft signs in bipolar and unipolar disorder: A case-control study

Sagheer, Tareq Al; Assaad, Shafika; Haddad, Georges; Hachem, Dory; Haddad, Chadia; Hallit, Souheil

doi:10.1016/j.psychres.2017.12.073

Cited by 16 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was suggested that NSS may be specifically associated with bipolar I disorder but not unipolar depression. The specificity of NSS expression reinforces the theory that NSS may play a potential role in early detection of the illness as a trait marker but not a state marker helping the discrimination of bipolar I disorder from disorders less likely to have a neurodevelopmental component [10].…”

Section: Introductionsupporting

confidence: 69%

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Safy

Masry

Shabrawy

et al. 2020

Middle East Curr Psychiatry

View full text Add to dashboard Cite

Background: Neurological soft signs in remitted state of bipolar disorder may represent trait deficits and the aim of this study was to examine the extent of neurological soft signs in euthymic patients with bipolar I disorder as compared to healthy controls. We conducted this study in Zagazig University Hospital upon 60 subjects divided into two groups: euthymic patients with bipolar I disorder group (30 patients) and control group (30 healthy individuals). Assessment of neurological soft signs was performed through Neurological Evaluation Scale and the euthymic state was determined by Young Mania Rating Scale and Hamilton Depression Rating Scale. Results: The euthymic patient group exhibited a significantly worse performance in the total Neurological Evaluation Scale and the whole four subtest scores than healthy control subjects. There was a statistically significant association between total neurological soft sign score and mood stabilizer therapy in the studied patients. The age of onset of the disorder was correlated to the total score of Neurological Evaluation Scale which is statistically significant. The best cutoff points of the total neurological soft signs score in the discrimination between the euthymic patient group and control group was 3.5 according to the receiver operating characteristic curve. Conclusion: This study may emphasize the role of neurological soft signs as a sign of organic brain disorder; however, further studies may be able to extend our findings to explore the etiology and pathogenesis of bipolar I disorder.

show abstract

Section: Introductionsupporting

confidence: 69%

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Safy

Masry

Shabrawy

et al. 2020

Middle East Curr Psychiatry

View full text Add to dashboard Cite

show abstract

“…A longitudinal investigation of subjects with bipolar disorder reported that clinician-rated agitation was the best discriminator between mood episodes, performing better than retardation, and most importantly, much better than mood symptoms of common clinical rating scales for depression and mania (Cheniaux et al ., 2018). Other motor abnormalities such as neurological soft signs are associated with psychosis in multiple disorders, including depression (Owoeye et al ., 2013; Sagheer et al ., 2018). In sum, psychomotor disturbances are of clinical value in determining poor outcome or treatment response.…”

mentioning

confidence: 99%

The utility of an RDoC motor domain to understand psychomotor symptoms in depression

Walther

Mittal

et al. 2018

Psychol. Med.

View full text Add to dashboard Cite

Despite the clinical impact of motor symptoms such as agitation or retardation on the course of depression, these symptoms are poorly understood. Novel developments in the field of instrumentation and mobile devices allow for dimensional and continuous recording of motor behavior in various settings, particularly outside the laboratory. Likewise, the use of novel assessments enables to combine multimodal neuroimaging with behavioral measures in order to investigate the neural correlates of motor dysfunction in depression. The research domain criteria (RDoC) framework will soon include a motor domain that will provide a framework for studying motor dysfunction in mood disorders. In addition, new studies within this framework will allow investigators to study motor symptoms across different stages of depression as well as other psychiatric diagnoses. Finally, the introduction of the RDoC motor domain will help test how motor symptoms integrate with the original five RDoC domains (negative valence, positive valence, cognitive, social processes, and arousal/regulation).

show abstract

“…Except for disinhibition, all NSS scores were higher in EBP than HC in this study. Sagheer et al evaluated the NSS in 50 patients with bipolar disorder and normal controls, the results indicated that patients with bipolar disorder had higher NSS total scores, motor coordination, and sensory integration scores than normal controls (Sagheer et al, 2018). A 2018 Meta-Analysis found that, despite the use of different instruments to assess the NSS, the majority of studies reported that, during episodes and remission, patients with bipolar disorder performed worse than normal controls on motor coordination and sensory integration items (Bora et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The aberrant neurodevelopmental theory of schizophrenia is supported by increased NSS (Bora et al, 2015), and some items in the NSS have been identified as probable endophenotypes of schizophrenia (Yingying et al, 2020;Yingying et al, 2017). Patients with bipolar disorder, for example, displayed much more motor coordination and sensory integration symptoms than healthy controls, according to case-control research (Sagheer et al, 2018). Additionally, patients with bipolar disorder experienced much more NSS than healthy controls, per the results of a 2018 meta-analysis (Bora et al, 2018).…”

Section: Introductionmentioning

confidence: 95%

Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder?

Feng

Song

Lin³

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Bipolar disorder’s potential endophenotypes include neurological soft signs (NSS) and neurocognitive disorders (ND). Few research, meanwhile, has coupled NSS and ND as combined endophenotypes of bipolar disorder. object This study intends to investigate NSS and ND and compare their differences in euthymic patients with bipolar disorder (EBP), their unaffected first-degree relatives (FDR), and healthy controls (HC). Additionally, search for potential endophenotypic subprojects of NSS and ND and construct and verify a composite endophenotypic. Methods The subjects were all Han Chinese and consisted of 86 EBP, 81 FDR, and 81HC. Cambridge Neurological Inventory and MATRICSTM Consensus Cognitive Battery tested NSS and ND independently. Results All three groups displayed a trapezoidal distribution of NSS levels and cognitive abnormalities, with EBP having the most severe NSS levels and cognitive deficits, followed by FDR and HC. Among them, motor coordination in NSS and Information processing speed (IPS), Verbal learning (VL), and Working memory (WM) in neurocognitive function are consistent with the traits of the endophenotype of bipolar disorder. The accuracy in differentiating EBP and HC or FDRs and HC was higher when these items were combined as predictor factors than in differentiating EBP and FDR. Conclusion These results provide more evidence that motor coordination, IPS, VL, and WM may be internal characteristics of bipolar disease. When these characteristics are combined into a complex endophenotype, it may be possible to distinguish bipolar disorder patients and high-risk groups from normal populations.

show abstract

Neurological soft signs in bipolar and unipolar disorder: A case-control study

Cited by 16 publications

References 27 publications

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

The utility of an RDoC motor domain to understand psychomotor symptoms in depression

Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder?

Contact Info

Product

Resources

About