Neurological syndromes occurring in patients receiving synthetic steroids (oral contraceptives)

Shafey, Sherif; Scheinberg, Peritz

doi:10.1212/wnl.16.2_part_1.205

Cited by 58 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The corresponding numbers who were using oral contraceptives were none, three, and seven respectively. Equally striking results have been published by Bickerstaff and Holmes (1967) and by Bergeron and Wood (1969), while Illis, Kocen, McDonald, and Mondkar (1965), Shafey and Scheinberg (1966), and Cole (1967) have all reported comparable findings. Only Jennett and Cross (1967) have reported negative results.…”

supporting

confidence: 63%

Epidemiological and public health aspects of oral contraceptives and thromboembolic disease

Vessey¹

1969

Journal of Clinical Pathology

View full text Add to dashboard Cite

show abstract

supporting

confidence: 63%

Epidemiological and public health aspects of oral contraceptives and thromboembolic disease

Vessey¹

1969

Journal of Clinical Pathology

View full text Add to dashboard Cite

show abstract

“…Since the introduction of oral contraceptives in 1961, there has been an increasing awareness of an apparent rise in thrombo-embolic strokes in young women that may be associated with their use (Zilkha, 1964 and1965;Baines, 1965;Shafey and Scheinberg, 1966). On the other hand Jennett and Cross (1967) have argued that this is not so, although Bickerstaff and Holmes (1967) believe that the apparent association between the use of oral contraceptives and the increased number of episodes of cerebral arterial insufficiency cannot be disregarded.…”

Section: Discussionmentioning

confidence: 99%

“…Many factors clearly influence the occurrence of thrombosis in major intracranial and extracranial cerebral arteries (Humphrey and Newton, 1960;Wisoff and Rothballer, 1961;Baker, Dahl, and Sandler, 1963) and of more recent concern is the possibly increased incidence of non-haemorrhagic strokes in young women taking oral contraceptives (Zilkha, 1964 and1965;Baines, 1965;Illis, Kocen, McDonald, and Mondkar, 1965;Nevin, Elmes, and Weaver, 1965;Shafey and Scheinberg, 1966;Bickerstaff and Holmes, 1967). Nevertheless it is generally believed that thrombus usually forms on an atheromatous plaque although this is not always confirmed by histological examination.…”

mentioning

confidence: 99%

Twelve cases of fatal cerebral infarction due to arterial occlusion in the absence of atheromatous stenosis or embolism.

Adams¹,

Graham²

1967

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

“…It is becoming increasingly apparent that CVA is associated with the administration of certain drugs. For example, the roles of oral contraceptives 37 and anticoagulant therapy 38 in CVA are well known. An association of CVA with monoamine oxidase inhibitors has also been described.…”

mentioning

confidence: 99%

Genetics of Cerebrovascular Accidents

Alter

Kluznik

1972

Stroke

View full text Add to dashboard Cite

Genetics of Cerebrovascular Accidents• The influence of heredity factors in cerebrovascular accidents was investigated by studying the families of 80 patients with a clinical diagnosis of CVA. The frequency of CVA in parents and siblings of these patients was compared with the frequency in the family of the patient's spouse. The frequency of recognized predisposing illnesses to CVA including hypertension, diabetes and heart disease was also studied. The patients and the spouses were excluded from the study population.Analysis of the data obtained on 160 parents and 384 sibs of the proband and on 140 parents and 336 sibs of the spouse revealed a frequency of CVA of 10.7% and 8.6% respectively. This difference was not statistically significant. However, when the sibs and parents were analyzed separately the difference between the sibs was significant (p < 0.025), suggesting the possibility that a small added risk of CVA existed for certain close relatives of a CVA victim.Besides an inherited tendency to CVA, other factors were considered to account for the difference in frequency of CVA. Age, family size and differential reporting of illness failed to account for the difference. However, both hypertension and heart disease occurred with greater frequency in the sibs of the patient. When patients with these predisposing illnesses were excluded and those with CVA alone were compared, it was found that relatives of the patient and the spouse had essentially the same frequency (3.1% and 3.2% respectively). Moreover, hypertension and heart disease were significantly more common in the relatives of the proband. The excess of CVA in the sibs of the proband could, therefore, have been due to an excess of predisposing illnesses such as hypertension and heart disease, and no independent inheritance of CVA was demonstrated. In the absence of certain predisposing illness, close relatives of CVA patients appeared to have no greater risk of CVA than genetically unrelated individuals. ADDITIONAL KEY WORDS Predisposing illnesses to CVA hypertension diabetes heart disease cerebral infarction inheritance arterial occlusion vascular malformations • Early reports on hereditary factors in cerebrovascular accidents (CVA) consisted primarily of descriptions of CVA in individual families.

show abstract

Neurological syndromes occurring in patients receiving synthetic steroids (oral contraceptives)

Cited by 58 publications

References 0 publications

Epidemiological and public health aspects of oral contraceptives and thromboembolic disease

Epidemiological and public health aspects of oral contraceptives and thromboembolic disease

Twelve cases of fatal cerebral infarction due to arterial occlusion in the absence of atheromatous stenosis or embolism.

Genetics of Cerebrovascular Accidents

Contact Info

Product

Resources

About