Neurology and COVID-19: Acting now. Preparing for future

Aggarwal, Annu; Singhal, Tanu; Bhatt, Mohit

doi:10.4103/aian.aian_513_20

Cited by 6 publications

(6 citation statements)

References 70 publications

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“…The profile of neurological manifestation is consistent with the earlier reported studies (summarised in Table 3 ). [ 14 15 16 17 ] Our study thereby confirms that COVID -19 infection can affect the nervous system in myriad ways and neurological manifestations of stroke, GBS and headache can be the sole manifestation or the presenting feature of COVID-19 infection, in more than 50% of patients.…”

Section: Discussionsupporting

confidence: 74%

The Spectrum of Neuro-COVID

Vengalil

Mahale

Chakradhar

et al. 2022

Annals of Indian Academy of Neurology

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Background: Though reports of neurological manifestations of COVID-19 have emerged from various parts of the world, the cohorts reported are from the West and mostly derived from electronic databases. Much remains unknown regarding neuro-COVID in developing countries. India is the second-worst affected country, and this study reports the neurological manifestations of COVID-19 in a comprehensively evaluated cohort. Objective: The aim of this study was to describe the range of neurological manifestations of COVID-19 in India with an emphasis on the risk factors, laboratory and imaging findings and short-term outcome. Methods: Retrospective review of hospital records of all confirmed COVID-19 patients with neurological manifestations, receiving inpatient care in two neurology referral hospitals were done. All demographic, clinical details, investigations, and treatment were analysed. Results: A total of 120 confirmed COVID-19 cases presenting with neurological symptoms were included. The mean age of illness and duration of illness was 48.03 ± 17.3 years and 10.9 ± 17.3 days respectively. New onset of neurological symptoms occurred in 100 cases while 20 patients had worsening of pre-existing neurological illness. Stroke was the commonest neurological disorder (43%), followed by encephalopathy (23%) and Guillain-Barre syndrome (10%). Other unusual neurological manifestations included new-onset headache (7%), seizures including denovo status epilepticus (5%) and meningo-encephalitis (5%). Nearly half of the patients had preceding COVID-19 symptoms. Poor outcome at discharge was seen in 40% and mortality occurred in 15%. Conclusion: Stroke and encephalopathy constitute the most common neurological manifestations. The absence of preceding COVID-19 symptoms in nearly half the cases is striking. Poor outcome was seen in nearly 50% despite early recognition and management.

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Section: Discussionsupporting

confidence: 74%

The Spectrum of Neuro-COVID

Vengalil

Mahale

Chakradhar

et al. 2022

Annals of Indian Academy of Neurology

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“…However, SARS‐CoV‐2, and to a certain extent MERS, can affect a variety of systems 1,94 . In particular, neurological symptoms develop in 20–80% of patients infected with SARS‐CoV‐2 and in isolated cases of SARS and MERS 95,96 …”

Section: Other Rna Virusesmentioning

confidence: 99%

“…1,94 In particular, neurological symptoms develop in 20-80% of patients infected with SARS-CoV-2 and in isolated cases of SARS and MERS. 95,96 Movement disorders are uncommon and, to date, only in a few dozen cases have been reported in patients with COVID-19. The most frequent being myoclonus, ataxia and opsoclonus due to systemic complications, structural lesions or as part of a postinfection syndrome (Video 8).…”

Section: Nipahmentioning

confidence: 99%

Video Anthology of Movement Disorders Due to Infections in South Asia

Aggarwal

Adukia

Bhatt

2021

Movement Disord Clin Pract

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South Asia, encompassing many populous countries including India, Pakistan, and Bangladesh, is home to a wide variety of infectious diseases several of which are disproportionately prevalent, endemic or distinctive to the region. These result in considerable morbidity and mortality, which can be greatly reduced through public‐health measures, timely diagnosis and treatment. Some of these infectious diseases have neurological manifestations including movement disorders either due to the pathogen being neuroinvasive or via an immune‐mediated response. For diseases such as Japanese encephalitis, movement disorders are the primary manifestation while for others, they can be a presenting feature. Thus, recognizing these movement disorders is often crucial to the diagnosis of the particular infection, and/or to exclude infection as a cause and arrive at the correct alternate diagnosis. Once diagnosed, the infection‐related movement disorders are treated by targeting the infectious agent, or symptomatically. In this article, we describe and illustrate a variety of movement disorders that are seen in patients infected by viruses, bacteria and parasites in South Asia. This would be of value to neurologists practicing in the region and, with the increasing ease in movement of people and pathogens, those practicing elsewhere.

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“…The availability of COVID-19 vaccines forced neurologists to acquire new skills on the selection of fragile neurological cases undergoing vaccination. Neurological disorders are more frequent in the elderly population with multiple comorbid conditions, or which require treatment with immunomodulatory therapies, which makes neurological patients susceptible to infections with increased risk of severe morbidity and mortality from COVID-19 [ 3 ]. The rapid approval of COVID-19 vaccines has caused doubts about their efficacy and safety.…”

Section: The Vaccine Campaigns and Neurological Complicationsmentioning

confidence: 99%

“…Severe neurological symptoms were more likely to occur in patients with severe COVID-19 disease, or more pre-existing comorbidities such as hypertension, obesity, and diabetes. Long- and short- term post-viral neurological sequelae also need to be monitored as a possibility [ 3 ]. It is speculated that SARS-CoV-2 might trigger neurodegenerative diseases like multiple sclerosis (MS), Parkinson’s disease (PD), and narcolepsy.…”

mentioning

confidence: 99%