Neurolymphomatosis of the Brachial Plexus and its Branches: Case Series and Literature Review

Bourque, Pierre R.; Warman‐Chardon, Jodi; Bryanton, Mark; Toupin, Melissa; Burns, Bruce F.; Torres, Carlos

doi:10.1017/cjn.2017.282

Cited by 27 publications

(19 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute plexopathy in the early phase of radiation therapy is also described, and they are often associated with pain. Rarely acute brachial plexopathy may be the manifestation of lymphoma infiltration or of neurolymphomatosis . Plexopathy in previously radiation‐treated lymphomas requires a thorough diagnostic assessment aiming at distinguishing tumor recurrence from post‐radiation myelopathy, which might exhibit the same clinical picture, although the first is generally more painful.…”

Section: Plexopathiesmentioning

confidence: 99%

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

View full text Add to dashboard Cite

The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune‐mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Some clinical findings, such a focal or diffuse involvement, symmetric or asymmetric pattern, presence of pain may point to the correct diagnosis. Besides a thorough medical history and neurological examination, neurophysiological studies, cerebrospinal fluid analysis, nerve biopsy (in selected patients with suspected lymphomatous infiltration) and neuroimaging techniques (magnetic resonance neurography and nerve ultrasound) may be crucial for a proper diagnostic workup.

show abstract

Section: Plexopathiesmentioning

confidence: 99%

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

View full text Add to dashboard Cite

show abstract

“…Neurolymphomatosis frequently poses a diagnostic dilemma, as it may often present as an isolated neuropathy without other overt lymphomatous development (10). One of the most remarkable features of the present case was that the NL, as a relapsed disease, had developed during a seemingly ongoing response to chemotherapy at other anatomical sites.…”

Section: Discussionmentioning

confidence: 73%

“…Although the affected patients commonly present with neuralgia in the involved sites, the definitive diagnosis of NL may often be delayed, since the presenting symptoms are highly variable and a wide range of differential diagnoses must be ruled out, including therapy-related neuropathy ( 9 ). Imaging studies, such as magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET), may alert clinicians to the affected sites and guide a biopsy for the pathological diagnosis ( 10 , 11 ). However, the highly invasive nature of a peripheral nerve biopsy as well as the highly progressive clinical course of NL may often preclude the timely diagnosis and implementation of treatment.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Resonance Imaging-negative, Rituximab-resistant Neurolymphomatosis as a Paradoxical Presentation of Relapsed Primary Adrenal Lymphoma

et al. 2020

View full text Add to dashboard Cite

Primary adrenal lymphoma (PAL) is rare and known to have a predilection for central nervous system (CNS) relapse. A 70-year-old man with a 2-year history of primary aldosteronism presented because of a fever. He was hypotensive, and his adrenal glands were unequivocally enlarged. PAL was diagnosed. Despite showing an initial response to immunochemotherapy, progressive paralysis ensued. Magnetic resonance imaging findings were negative, and rituximab was ineffective. His debilitated condition hindered further chemotherapy. A postmortem examination revealed lymphoma relapse in the systemic peripheral nerves. The sequential presentation of two rare lymphomas implies that PAL might have a predilection for not only the CNS but also peripheral nerves.

show abstract

“…Lymphoma can encase the plexi due to enlarged lymph nodes and, when primarily involving the nerve roots and trunks, demonstrates increased signal and nerve enlargement. In neurolymphomatosis, there is neoplastic endoneurial invasion, most often associated with non-Hodgkin's lymphoma [37]. Prominent asymmetry, pain, and nodular MRI appearance may help distinguish neurolymphomatosis from paraneoplastic immune demyelinating radiculoneuropathy.…”

mentioning

confidence: 99%

“…Prominent asymmetry, pain, and nodular MRI appearance may help distinguish neurolymphomatosis from paraneoplastic immune demyelinating radiculoneuropathy. MRN shows T2/STIR hyperintensity, focal and diffuse nerve enlargement with fascicular disorganization, and enhancement [37]. Primary neoplasms in close vicinity to the BP, such as bronchogenic carcinoma/Pancoast tumors of the thoracic apex (Fig.…”

mentioning

confidence: 99%