Neuromagnetic source localization of auditory evoked fields and intracerebral evoked potentials: a comparison of data in the same patients

Godey, Benoît; Schwartz, Denis; Graaf, Jozina B. De; Chauvel, Patrick; Liégeois‐Chauvel, Catherine

doi:10.1016/s1388-2457(01)00636-8

Cited by 322 publications

(216 citation statements)

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“…The primary auditory cortex, the lateral aspects of which are assumed to harbor the P50 generator (Godey, 2001), is not directly accessible with the subdural and intrahippocampal depth electrodes used in the present study. Hence, the lateral temporal strip and grid electrodes may represent components originally generated in Heschl's gyrus.…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…Hence, the lateral temporal strip and grid electrodes may represent components originally generated in Heschl's gyrus. Unfortunately, there are as yet no invasive gating studies in patients with temporal depth electrodes inserted along a lateral-medial axis, although the P50 component as such has been investigated by such an approach (Godey, 2001). …”

Section: Methodological Considerationsmentioning

confidence: 99%

“…Previous invasive electrophysiological and MEG studies have suggested that the P50 response is generated in the primary auditory cortex (Liegeois-Chauvel, 1994;Godey, 2001;Scherg, 1989). Furthermore, there is now accumulating evidence from invasive EEG (Grunwald et al, 2003), EP source analyses (Weisser, 2001) and MEG (Thoma, 2003) studies that P50 sensory gating in a double-click paradigm is also topographically related to that sensory area.…”

Section: Clues To An Understanding Of Sensory Gatingmentioning

confidence: 99%

“…However, later studies located the P50 generator mainly bilaterally in temporal areas close to the auditory cortex (Godey et al, 2001;Weisser et al, 2001). In surface ERP studies, the P50 is usually maximal over the vertex, but this finding allows no straight conclusion concerning the cerebral sources of that response, since different cortical source configurations can produce a unique scalp voltage topography (Slotnick 2005).…”

Section: Introductionmentioning

confidence: 99%

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Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Kurthen

Trautner

Rosburg

et al. 2007

Psychiatry Research: Neuroimaging

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The filtering of sensory information, also referred to as "sensory gating", is impaired in various neuropsychiatric diseases. In the auditory domain, sensory gating is investigated mainly as a response decrease of the auditory evoked potential component P50 from one click to the second in a double click paradigm. In order to relate deficient sensory gating to anatomy, it is essential to identify the cortical structures involved in the generation of P50. However, the exact cerebral topography of P50 gating has remained largely unknown as yet. In a group of 17 patients with drug-resistant focal epilepsy, P50 was recorded invasively via subdural electrodes, and the topography of functionally indispensable ("eloquent") cortices was obtained by electrical stimulation mapping. These eloquent areas were involved in language, motor, and sensory functions. P50 could be identified in 13 patients in either temporal (n = 8) or midfrontal sites (n = 5). There were 6 occurrences (in 5 patients) of overlap of sites with maximal P50 responses and eloquent areas. Those were auditory (n = 1), supplementary sensorimotor (n = 3), primary motor (n = 1), and supplementary negative motor (n = 1). Results suggest that the early stage of sensory gating already involves a top-down modulation of sensory input by frontal areas.

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Section: Methodological Considerationsmentioning

confidence: 99%

Section: Methodological Considerationsmentioning

confidence: 99%

Section: Clues To An Understanding Of Sensory Gatingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Kurthen

Trautner

Rosburg

et al. 2007

Psychiatry Research: Neuroimaging

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“…In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al, 1991). We and others have previously shown that patients with schizophrenia demonstrate disturbed inter-hemispheric asymmetry of the M100 generator location , Reite et al, 1989, Rockstroh et al, 2001, Tiihonen et al, 1998.The M100 component appears to be generated by lateral aspects of the transverse gyrus of Heschl and the planum temporale of the superior temporal gyrus (Godey et al, 2001, Reite et al, 1994. Abnormal planum temporale asymmetry has also been implicated as disturbed in schizophrenia (e.g., Shapleske et al, 1999 for a review).…”

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confidence: 86%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

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Deficits in basic auditory perception have been described in schizophrenia. Previous electrophysiological imaging research has documented a structure-function disassociation in the auditory system and altered tonotopic mapping in schizophrenia. The present study examined auditory cortical tuning in patients with schizophrenia.Eighteen patients with schizophrenia and 15 comparison subjects were recorded in a magnetoencephalographic (MEG) experiment of auditory tuning. Auditory cortical tuning at 1 kHz was examined by delivering 1 kHz pure tones in conjunction with pure tones at 5 frequencies surrounding and including 1 kHz. Source reconstruction data were examined for evidence of frequency specificity for the M100 component.There was a significant broadening of tuning in the schizophrenia group evident for the source amplitude of the M100. The frequently reported reduction in anterior-posterior source asymmetry for individuals with schizophrenia was replicated in this experiment. No relationships between symptom severity ratings and MEG measures were observed.This finding suggests that the frequency specificity of the M100 auditory evoked field is disturbed in schizophrenia, and may help explain the relatively poor behavioral performance of schizophrenia patients on simple frequency discrimination tasks. KeywordsMagnetoencephalography; Evoked Potentials; Auditory Cortex; Mental Illness; N100; M100 Corresponding Author: Donald C. Rojas, Ph.D. Box C268−68 CPH Rm 2J10 4200 E. 9th Avenue Denver, CO 80262 Phone: (303) 315 −8624 FAX: (303) 315−5641 email: Don.Rojas@uchsc.edu. Contributors D.C.R designed the study, performed the statistical analysis and wrote the manuscript. E.S. contributed data analyses and preliminary statistical analyses. P.D.T. contributed to the design of the experiment and selection of data analytic strategies and M.L.R. had substantial input on clinical aspects of the design, including selection and implementation of schizophrenia diagnostic and clinical measures appearing in the paper. All authors have contributed to and approved the final manuscript.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of InterestAll authors declare that they have no conflicts of interest with respect to this manuscript. NIH Public Access IntroductionThe M100 auditory evoked field has been reported to show anomalous anterior-posteior source location asymmetry in actively psychotic patients with paranoid schizophrenia. In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al., 1991). We and ...

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Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study

Okamoto

Kakigi

2014

Brain and Behavior

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IntroductionPrevious studies demonstrated that a decrement in the N1m response, a major deflection in the auditory evoked response, with sound repetition was mainly caused by bottom-up driven neural refractory periods following brain activation due to sound stimulations. However, it currently remains unknown whether this decrement occurs with a repetition of silences, which do not induce refractoriness.MethodsIn the present study, we investigated decrements in N1m responses elicited by five repetitive silences in a continuous pure tone and by five repetitive pure tones in silence using magnetoencephalography.ResultsRepetitive sound stimulation differentially affected the N1m decrement in a sound type-dependent manner; while the N1m amplitude decreased from the 1st to the 2nd pure tone and remained constant from the 2nd to the 5th pure tone in silence, a gradual decrement was observed in the N1m amplitude from the 1st to the 5th silence embedded in a continuous pure tone.ConclusionsOur results suggest that neural refractoriness may mainly cause decrements in N1m responses elicited by trains of pure tones in silence, while habituation, which is a form of the implicit learning process, may play an important role in the N1m source strength decrements elicited by successive silences in a continuous pure tone.

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Neuromagnetic source localization of auditory evoked fields and intracerebral evoked potentials: a comparison of data in the same patients

Abstract: The results suggest that both techniques are useful and may be used together in a complementary fashion. Intracerebral recordings allow the researcher to validate and interpret surface recordings.

Cited by 322 publications

References 28 publications

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Neural adaptation to silence in the human auditory cortex: a magnetoencephalographic study

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