Neuromediated action of β-casomorphins on ion transport in rabbit ileum

Tomé, Daniel; Mansour, Abderraouf Ben; Hautefeuille, M; Dumontier, A M; Desjeux, J. F.

doi:10.1051/rnd:19880604

Cited by 19 publications

(7 citation statements)

References 13 publications

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“…In the present study, the CH-evoked mucin discharge was fully blocked by intra-arterial infusion of TTX, thus suggesting the involvement of intramural neurones. The effect of a synthetic analog of casomorphins, ␤-[DAla2,4, Tyr5] CM-5-NH 2 on ion transport in rabbit ileum in vitro was also found to be mediated neurally (39). A striking finding was that naloxone, an antagonist at opioid receptors, completely inhibited the mucin release induced by 0.5% CH.…”

Section: Discussionmentioning

confidence: 92%

Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum

Claustre

Toumi

Trompette

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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The hypothesis that dietary proteins or their hydrolysates may regulate intestinal mucin discharge was investigated in the isolated vascularly perfused rat jejunum using an enzyme-linked immunosorbent assay for rat intestinal mucins. On luminal administration, casein hydrolysate [0.05-5% (wt/vol)] stimulated mucin secretion in rat jejunum (maximal response at 417% of controls). Lactalbumin hydrolysate (5%) also evoked mucin discharge. In contrast, casein, and a mixture of amino acids was without effect. Chicken egg albumin and its hydrolysate or meat hydrolysate also did not modify mucin release. Interestingly, casein hydrolysate-induced mucin secretion was abolished by intra-arterial TTX or naloxone (an opioid antagonist). beta-Casomorphin-7, an opioid peptide released from beta-casein on milk ingestion, induced a strong mucin secretion (response at 563% of controls) that was inhibited by naloxone. Intra-arterial beta-casomorphin-7 also markedly increased mucin secretion (410% of controls). In conclusion, two enzymatic milk protein hydrolysates (casein and lactalbumin hydrolysates) and beta-casomorphin-7, specifically, induced mucin release in rat jejunum. The casein hydrolysate-induced mucin secretion is triggered by a neural pathway and mediated by opioid receptor activation.

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Section: Discussionmentioning

confidence: 92%

Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum

Claustre

Toumi

Trompette

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…La question qui se pose à la suite de ces résultats est évidemment celle de la nature de l'analogue du DFP présent dans les hydrolysats de caséine fi ou d'autres caséines, à même d'inhiber l'activité transépithéliale de la dipeptidylpeptidase IV. Les derniers résultats acquis par Tomé et al (1988) montrent, en effet, que les récepteurs des casomorphines naturelles ou de leurs analogues sont problablement situés dans les neurones sous-muqueux, ce qui exige l'absorption de ces composés dans leur intégrité. Une telle localisation des récepteurs amène à formuler l'hypothèse selon laquelle l'activité anti-sécrétoire et anti-diarrhéique des casomorphines serait indirecte et donc neuromédiée.…”

Section: Peptides à Activité Opiacéeunclassified

“…Une telle localisation des récepteurs amène à formuler l'hypothèse selon laquelle l'activité anti-sécrétoire et anti-diarrhéique des casomorphines serait indirecte et donc neuromédiée. L'inhibition de cette activité constatée par Tomé et al (1988) lorsqu'il y avait adjonction de composés bloquant la transmission nerveuse (tetrodoxine -épinédrine) appuie fortement cette hypothèse.…”

Section: Peptides à Activité Opiacéeunclassified

Peptides du lait à activité biologique

Maubois

Léonil

1989

Lait

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“…These peptides also showed an anti-secretory effect on the rabbit ileum [78,79]. The enhancement of net water and electrolyte absorption by -casomorphins in the small and large intestines may be a major component of their antidiarrhoeal action.…”

Section: Modulation Of Gastrointestinal Functionsmentioning

confidence: 92%

Food-Derived Peptides and Intestinal Functions

Shimizu¹,

Son

2007

CPD

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The intestines are an important organ responsible for nutrient absorption, metabolism and recognition of food signals. The organ also acts as a physical and biological barrier against harmful substances including food pathogens and environmental chemicals. Food-derived peptides with a variety of physiological functions have been discovered in the past several decades. Although dietary peptides would mostly be hydrolyzed by digestive enzymes in the intestinal tract, possibly losing their biological functions during this step, some could be absorbed intact and act in their target organs. The intestines are also one of the targets for functional peptides. The intestine-modulatory peptides can be classified into two categories: (1) peptides that express their functions in the intestinal tract and (2) peptides that modulate intestinal epithelial cell functions. The 1(st) group includes peptides that regulate the intestinal absorption of nutrients. Enhancing mineral absorption by casein phosphopeptides, and suppressing dietary cholesterol absorption by soybean peptides are typical examples. The 2(nd) group includes such glutamine-containing peptides as Ala-Gln that show interesting properties in preventing and/or repairing damage caused by oxidative stress and inflammatory reactions. We have found that carinosine (beta-Ala-His) suppressed the secretion of such inflammatory cytokines as IL-8 in human intestinal epithelial cells, suggesting its anti-inflammatory function in the intestines. Peptides that modulate such intestinal immune functions as secretory IgA production and cytokine secretion, and opioid peptides regulating intestinal motility are also included in this group. These intestine-modulatory peptides would be useful as ingredients of future functional foods to prevent lifestyle-related diseases and promote gut health.

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Neuromediated action of β-casomorphins on ion transport in rabbit ileum

Abstract: Summary. 8-casomorphins (, Introduction.

Cited by 19 publications

References 13 publications

Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum

Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum

Peptides du lait à activité biologique

Food-Derived Peptides and Intestinal Functions

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