Neurometabolic and microstructural alterations following a sports-related concussion in female athletes

Chamard, Émilie; Lassonde, Maryse; Henry, Luke C.; Tremblay, Julie; Boulanger, Yvan; Beaumont, Louis De; Théoret, Hugo

doi:10.3109/02699052.2013.794968

Cited by 86 publications

(85 citation statements)

References 56 publications

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“…For example, magnetic resonance spectroscopy (MRS) studies have demonstrated neurometabolic changes after SRC lasting up to 1 month postinjury. [6][7][8][9] Similarly, in a functional MRI study, hyperactivation of the dorsolateral prefrontal cortex was found to persist beyond 2 months postinjury in athletes whose symptoms subsided at 2 weeks after injury. 10 DTI studies demonstrating structural changes from repetitive concussive head impacts have been reported in ice hockey players over the course of a single season, 11 in athletes with prolonged symptoms, 12 as well as in adolescents exhibiting close-to-normal scores on the Sports Concussion Assessment Tool (SCAT2) 13 at 2 months postinjury.…”

Section: Introductionmentioning

confidence: 86%

“…31 In college athletes exhibiting prolonged symptoms after SRC, increased MD has been reported in parts of the left inferior/superior longitudinal and fronto-occipital fasciculi, the retrolenticular part of the internal capsule, and posterior thalamic and acoustic radiations. 12 Persistent microstructural alterations in deep WM have been shown in female contact sports athletes at 7 months postinjury 6 ; all participants were symptom free at this point of their recovery, suggesting that, in female athletes, structural recovery may lag behind behaviorally assessed recovery by up to 7 months postinjury. Finally, changes in WM microstructure were observed in a cohort of contact sports athletes with subconcussive blows to the head (26-399 hits), whereas no such changes were identified in 6 control participants.…”

Section: Introductionmentioning

confidence: 91%

“…Finally, changes in WM microstructure were observed in a cohort of contact sports athletes with subconcussive blows to the head (26-399 hits), whereas no such changes were identified in 6 control participants. 32 There is thus growing evidence suggesting that even in the absence of clinically symptomatic concussions (i.e., subconcussive hits) [31][32][33] or at a stage of recovery when athletes are symptom free, 6 they are likely to exhibit WM alterations when advanced neuroimaging techniques are used to examine their brains. These findings suggest that DTI may be a useful imaging tool to assess the severity of a concussion and may provide a biomarker for structural injury.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Longitudinal Diffusion Tensor Imaging Study Assessing White Matter Fiber Tracts after Sports-Related Concussion

Murugavel

Cubon

Putukian

et al. 2014

Journal of Neurotrauma

105

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The extent of structural injury in sports-related concussion (SRC) is central to the course of recovery, long-term effects, and the decision to return to play. In the present longitudinal study, we used diffusion tensor imaging (DTI) to assess white matter (WM) fiber tract integrity within 2 days, 2 weeks, and 2 months of concussive injury. Participants were righthanded male varsity contact-sport athletes (20.2 -1.0 years of age) with a medically diagnosed SRC (no loss of consciousness). They were compared to right-handed male varsity non-contact-sport athletes serving as controls (19.9 -1.7 years). We found significantly increased radial diffusivity (RD) in concussed athletes (n = 12; paired t-test, tract-based spatial statistics; p < 0.025) at 2 days, when compared to the 2-week postinjury time point. The increase was found in a cluster of right hemisphere voxels, spanning the posterior limb of the internal capsule (IC), the retrolenticular part of the IC, the inferior longitudinal fasciculus, the inferior fronto-occipital fasciculus (sagittal stratum), and the anterior thalamic radiation. Post-hoc, univariate, between-group (controls vs. concussed), mixed-effects analysis of the cluster showed significantly higher RD at 2 days ( p = 0.002), as compared to the controls, with a trend in the same direction at 2 months ( p = 0.11). Results for fractional anisotropy (FA) in the same cluster showed a similar, but inverted, pattern; FA was decreased at 2 days and at 2 months postinjury, when compared to healthy controls. At 2 weeks postinjury, no statistical differences between concussed and control athletes were found with regard to either RD or FA. These results support the hypothesis of increased RD and reduced FA within 72 h postinjury, followed by recovery that may extend beyond 2 weeks. RD appears to be a sensitive measure of concussive injury.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Longitudinal Diffusion Tensor Imaging Study Assessing White Matter Fiber Tracts after Sports-Related Concussion

Murugavel

Cubon

Putukian

et al. 2014

Journal of Neurotrauma

105

View full text Add to dashboard Cite

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“…Changes in functional and structural connectivity in the brain, neurometabolism, and heart-rate variability have been observed at medical clearance in athletes with SRC (27)(28)(29)(30). In addition, we recently identified elevated peripheral blood chemokine levels in healthy athletes participating in collision sports (14).…”

Section: Introductionmentioning

confidence: 99%

An investigation of neuroinjury biomarkers after sport-related concussion: from the subacute phase to clinical recovery

et al. 2018

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Objectives: To characterise a panel of neuroinjury-related blood biomarkers after sport-related concussion (SRC). We hypothesised significant differences in biomarker profiles between athletes with SRC and healthy controls at both subacute and medical clearance time points. Methods: Thirty-eight interuniversity athletes were recruited over two athletic seasons (n = 19 SRC; n = 19 healthy matched-control). High-sensitivity immunoassay was used to evaluate 11 blood analytes at both the subacute phase after SRC and at medical clearance. Results: Univariate analysis identified elevated circulating peroxiredoxin-6 (PRDX-6) in athletes with SRC compared to healthy controls at the subacute time point. Multivariate analyses yielded similar results in the subacute phase, but identified both PRDX-6 and T-tau as significant contributors to class separation between athletes with SRC and controls at medical clearance. Conclusions: Our results are consistent with the increasing recognition that physiological recovery after SRC extends beyond clinical recovery. Blood biomarkers appear to be useful in elucidating the biology of brain restitution after SRC. However, their implementation requires mindfulness of factors such as academic stress, exercise, and injury heterogeneity. ARTICLE HISTORY

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“…По мнению авторов, детский мозг может иметь нейропротекторный механизм, которого нет у взрослых. Chamard Е. и коллеги [8] показали снижение креатина спустя семь месяцев после сотрясения в моторной зоне коры. У женщин отмечается более выраженное снижениe NAA/креатина на протяжении сезона по сравнению с мужчинами.…”

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The Problem of Encephalopathy in Athletes

Tolstova¹,

Akulina²,

Mazikin³

2017

Zdor. obraz. XXI veke (Èlektronnyj vestnik)

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Аннотация. Статья посвящена поиску неинвазивных нейровизуальных методов исследования, представляющих ключевые биомаркеры для выявления ранних признаков изменений головного мозга в контактных видах спорта по данным литературы. Проанализирована роль некоторых методов МРТ для диагностики и мониторинга пато-логических изменений в тканях головного мозга по данным зарубежных авторов. Найдены обнадеживающие ре-зультаты в предоставлении ключевых биомаркеров для мониторинга, которые отражают диффузные аксональ-ные травмы, нейродегенеративные процессы, демонстрирующие разные модели активации мозга. Представлены результаты оценки повреждений у спортсменов с помощью тау-белка, перспективные направления изучения осо-бенностей церебрального метаболизма. Ключевые слова: энцефалопатия, МР-спектроскопия, позитронно-эмиссионная томография, диффузионно-взвешенные изображения.До недавнего времени о проблеме энцефа-лопатии у занимающихся контактными видами спорта не говорили вообще. То, что проблема озвучена, вызывает живой интерес исследовате-лей. В настоящее время только появились науч-ные доказательства взаимосвязи между патологи-ческими изменениями в головном мозге и повтор-ными сотрясениями у бывших профессиональных спортсменов [1]. Хроническая травматическая эн-цефалопатия (ХТЭ) приводит к целому спектру проблем: тяжелые головные боли, депрессия, нарушение сна, агрессивность, склонность к са-моубийству. До сих пор нет убедительных дока-зательств того, что ХТЭ является единым феноме-ном или что она провоцируется исключительно травмами. Комплекс симптомов пересекается с другими заболеваниями, которые могут сопут-ствовать ХТЭ у пациентов с этим диагнозом. Осо-бенно это касается поведенческих симптомов, причины которых плохо понятны во многих слу-чаях. Взаимосвязь между боксом и классической ХТЭ доказана и не оспаривается большинством ученых. В последующем энцефалопатия боксеров диагностировалась и у участников авторалли, и у конных наездников, т.е. там, где имеют место быть травмы и повреждения головного мозга. Па-тологические последствия повторяющихся че-репно-мозговых травм (ЧМТ) вызывают расту-щую озабоченность представителей контактных видов спорта. В то же время, взаимосвязь между повтор-ными легкими ЧМТ и клинической формой ХТЭ в настоящее время существует на уровне гипотез. По данным Тарасова А.Б., 90% сотрясений голов-ного мозга протекает без потери сознания, а 5-20% возникают без прямой травмы головы (кон-такт плечо в плечо, что приводит к резкому замед-лению спортсмена). Реальная распространен-ность сотрясений мозга не известна.Хотя травма может быть необходимым условием для развития энцефалопатии, механизм, по которому это могло быть, не известен. Воз-можно, травма инициирует патогенетический кас-кад, приводящий к нейродегенерации. Регулярное ударное воздействие извне способствует посте-пенному видоизменению аксонов, а в дальнейшем и микротравмам, разрывам некрупных сосудов. Постепенно развиваются очаговые ишемии и дис-трофические участки мозга, склонные к слиянию и усугублению болезни.Цель настоящего исследования закл...

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Neurometabolic and microstructural alterations following a sports-related concussion in female athletes

Abstract: This study demonstrates persistent neurometabolic and microstructural alterations in female athletes suffering a sports-related concussion.

Cited by 86 publications

References 56 publications

A Longitudinal Diffusion Tensor Imaging Study Assessing White Matter Fiber Tracts after Sports-Related Concussion

A Longitudinal Diffusion Tensor Imaging Study Assessing White Matter Fiber Tracts after Sports-Related Concussion

An investigation of neuroinjury biomarkers after sport-related concussion: from the subacute phase to clinical recovery

The Problem of Encephalopathy in Athletes

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