NeuroMix—A single‐scan brain exam

Sprenger, Tim; Kits, Annika; Norbeck, Ola; Niekerk, Adam van; Berglund, Johan; Rydén, Henric; Avventi, Enrico; Skare, Stefan

doi:10.1002/mrm.29120

Cited by 12 publications

(11 citation statements)

References 47 publications

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“…A new sequence called NeuroMix has been introduced, which improves upon some of the shortcomings of EPIMix by adding FSE-based read-out for T2 and FLAIR sequences. [ 18 ] This may also be evaluated in the clinical setting by future studies.…”

Section: Discussionmentioning

confidence: 99%

Multi-contrast echo-planar imaging sequence (Echo-planar imaging mix) in clinical situations demanding faster MRI-brain scans

Ganesh,

Kamepalli,

Sharma

et al. 2024

JNRP

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Objectives: The excellent resolution offered by magnetic resonance imaging (MRI) has a trade-off in the form of scan duration. The purpose of the present study was to assess the clinical utility of echo-planar imaging mix (EPIMix), an echo-planar imaging-based MRI sequence for the brain with a short acquisition time. Materials and Methods: This was a retrospective observational study of 50 patients, who could benefit from faster MRI brain scans. The T1, T2, fluid attenuated inversion recovery, diffusion-weighted imaging (DWI), and T2*/susceptibility-weighted imaging sequences were acquired, conventionally and with EPIMix. Conventional and EPIMix images were assessed by two radiologists for overall quality, motion, and susceptibility artifacts and scored on a Likert scale. The scores given for conventional and EPIMix images were compared. The diagnostic performance of EPIMix was also assessed by the ability to detect clinically relevant findings. Results: The acquisition time for conventional MRI was 11 min and 45 s and for EPIMix 1 min and 15 s. All EPIMix images were sufficient for diagnostic use. On assessment of the diagnostic performance, it was excellent for ischemic and hemorrhagic strokes. Smaller lesions, lesions adjacent to bone, and post-operative tumors were difficult to identify. Moderate to perfect agreement (Kappa values 0.41–1) was seen between radiologists for all categories except skull base, calvarial, and orbital lesions. Image quality, artifact assessment showed excellent interobserver agreement (>90%) for the scores. All EPIMix images showed reduced motion artifacts. The EPIMix-DWI was comparable to conventional-DWI in terms of quality and artifacts. The remaining sequences showed reduced quality and increased susceptibility. Conclusion: The EPIMix has a significantly reduced acquisition time than conventional MRI and could be used instead of conventional MRI in situations demanding faster scans such as suspected acute ischemic or hemorrhagic stroke. In other clinical scenarios, it could help tailor the MRI examination for each patient.

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Section: Discussionmentioning

confidence: 99%

Multi-contrast echo-planar imaging sequence (Echo-planar imaging mix) in clinical situations demanding faster MRI-brain scans

Ganesh,

Kamepalli,

Sharma

et al. 2024

JNRP

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“…For patients in the (post) acute setting, motion artifacts can lead to poor image quality. However, recent advances with accelerated sequences and thus short scan times may partially offset this issue [59,60]. There is also the question of cost which will vary regionally and according to local healthcare and insurance policies.…”

Section: Suggested Imaging Toolbox For Cerebroprotection Trialsmentioning

confidence: 99%

How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection?

et al. 2022

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“…Despite a short acquisition time of just over 1 min, high diagnostic performance for acute cerebral infarction has been reported [ 2 , 3 ]. Recently, this technique has been further developed to improve resolution and signal-to-noise ratio while reducing geometric distortions [ 4 ] by replacing EPI with motion-insensitive [ 5 ] single-shot fast spin echo (SSFSE)-based T2-weighted and T2-FLAIR and adding three-dimensional SWI-EPI and T1-weighted EPI within a total acquisition time below 3 min. NeuroMix provides seven different contrasts (DWI/ADC, SSFSE T2-weighted, SSFSE T2-FLAIR, T2*, T1-weighted, 3D SWI-EPI, 3D T1-EPI) in one continuous scan.…”

Section: Introductionmentioning

confidence: 99%

2.5-Minute Fast Brain MRI with Multiple Contrasts in Acute Ischemic Stroke

Kits,

Al-Saadi,

De Luca

et al. 2024

Neuroradiology

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Purpose To assess the performance of a 2.5-minute multi-contrast brain MRI sequence (NeuroMix) in diagnosing acute cerebral infarctions. Methods Adult patients with a clinical suspicion of acute ischemic stroke were retrospectively included. Brain MRI at 3 T included NeuroMix and routine clinical MRI (cMRI) sequences, with DWI/ADC, T2-FLAIR, T2-weighted, T2*, SWI-EPI, and T1-weighted contrasts. Three radiologists (R1–3) independently assessed NeuroMix and cMRI for the presence of acute infarcts (DWI ↑, ADC = or ↓) and infarct-associated abnormalities on other image contrasts. Sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC) were calculated and compared using DeLong’s test. Inter- and intra-rater agreements were studied with kappa statistics. Relative DWI (rDWI) and T2-FLAIR (rT2-FLAIR) signal intensity for infarctions were semi-automatically rendered, and the correlation between methods was evaluated. Results According to the reference standard, acute infarction was present in 34 out of 44 (77%) patients (63 ± 17 years, 31 men). Other infarct-associated signal abnormalities were reported in similar frequencies on NeuroMix and cMRI (p > .08). Sensitivity for infarction detection was 94%, 100%, and 94% evaluated by R1, R2, R3, for NeuroMix and 94%, 100%, and 100% for cMRI. Specificity was 100%, 90%, and 100% for NeuroMix and 100%, 100%, and 100% for cMRI. AUC for NeuroMix was .97, .95, and .97 and .97, 1, and 1 for cMRI (DeLong p = 1, .32, .15), respectively. Inter- and intra-rater agreement was κ = .88–1. The correlation between NeuroMix and cMRI was R = .73 for rDWI and R = .83 for rT2-FLAIR. Conclusion Fast multi-contrast MRI NeuroMix has high diagnostic performance for detecting acute cerebral infarctions.

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NeuroMix—A single‐scan brain exam

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 12 publications

References 47 publications

Multi-contrast echo-planar imaging sequence (Echo-planar imaging mix) in clinical situations demanding faster MRI-brain scans

Multi-contrast echo-planar imaging sequence (Echo-planar imaging mix) in clinical situations demanding faster MRI-brain scans

How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection?

2.5-Minute Fast Brain MRI with Multiple Contrasts in Acute Ischemic Stroke

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