Neuromodulation in Post-stroke Aphasia Treatment

Breining, Bonnie L.; Sebastian, Rajani

doi:10.1007/s40141-020-00257-5

Cited by 26 publications

(20 citation statements)

References 69 publications

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“…[150][151][152] Moreover, converging evidence has suggested that both stimulation and psychotherapy can modulate brain connectivity, 153,154 pointing to the possible importance of time-locking brain stimulation and behavioural engagement to investigate the possibility of maximizing their effects. A similar approach has been applied with stroke patients in the neurorehabilitation field, combining noninvasive brain stimulation with motor and speech training (for recent reviews, see Breining and Sebastian 155 and Pruski and Cantarero 156 ). In neuropsychiatric disorders, the investigation of combined interventions is still in its infancy, 41,157 even for the treatment of depression, which has received more research attention.…”

Section: Combination Of Psychological Intervention and Neurostimulationmentioning

confidence: 99%

Effectiveness of noninvasive brain stimulation in the treatment of anxiety disorders: a meta-analysis of sham or behaviour-controlled studies

Vergallito

Gallucci

Pisoni

et al. 2021

jpn

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Section: Combination Of Psychological Intervention and Neurostimulationmentioning

confidence: 99%

Effectiveness of noninvasive brain stimulation in the treatment of anxiety disorders: a meta-analysis of sham or behaviour-controlled studies

Vergallito

Gallucci

Pisoni

et al. 2021

jpn

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“…Patients with post-stroke aphasia (PSA) often have impaired upper extremity (UE) motor and cognitive function [ 1 , 2 , 3 ]. Non-invasive brain stimulation (NIBS), specifically transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), are emerging as promising NIBS modalities in treating the language and motor dysfunction of stroke patients [ 4 , 5 , 6 , 7 , 8 ]. Intriguingly, not only have the NIBS targeting the “motor” or “language” areas been proven beneficial for improving the patients’ motor or language performances, respectively [ 2 ], but recent studies have also reported that NIBS targeting the motor area (i.e., M1) could also improve the language function of the PSA patients [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study

et al. 2021

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Intermittent theta-burst stimulation (iTBS) is a high-efficiency transcranial magnetic stimulation (TMS) paradigm that has been applied to post-stroke aphasia (PSA). However, its efficacy mechanisms have not been clarified. This study aimed to explore the immediate effects of iTBS of the primary motor cortex (M1) of the affected hemisphere, on the functional activities and connectivity of the brains of PSA patients. A total of 16 patients with aphasia after stroke received iTBS with 800 pulses for 300 s. All patients underwent motor, language, and cognitive assessments and resting-state functional MRI scans immediately before and after the iTBS intervention. Regional, seed-based connectivity, and graph-based measures were used to test the immediate functional effects of the iTBS intervention, including the fractional amplitude of low-frequency fluctuation (fALFF), degree centrality (DC), and functional connectivity (FC) of the left M1 area throughout the whole brain. The results showed that after one session of iTBS intervention, the fALFF, DC, and FC values changed significantly in the patients’ brains. Specifically, the DC values were significantly higher in the right middle frontal gyrus and parts of the left parietal lobe (p < 0.05), while fALFF values were significantly lower in the right medial frontal lobe and parts of the left intracalcarine cortex (p < 0.05), and the strength of the functional connectivity between the left M1 area and the left superior frontal gyrus was reduced (p < 0.05). Our findings provided preliminary evidences that the iTBS on the ipsilesional M1 could induce neural activity and functional connectivity changes in the motor, language, and other brain regions in patients with PSA, which may promote neuroplasticity and functional recovery.

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“…Non-invasive inhibitory brain stimulation of right inferior frontal gyrus or right superior temporal sulcus has not allowed to resolve this issue unequivocally yet. 59,61 Based on the published studies, overall there seems to be a potential beneficial effect of inhibitory non-invasive stimulation of these regions in post-stroke aphasia but publication bias and small effect sizes render interpretation difficult.…”

Section: Discussionmentioning

confidence: 99%

Changes in the language system as amyloid-β accumulates

Reinartz

Gabel

Schaeverbeke

et al. 2021

Brain

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Language dysfunction is common in Alzheimer’s disease. There is increasing interest in the preclinical or asymptomatic phase of Alzheimer’s disease. Here we examined in 35 cognitively intact older adults (age range 52–78 years at baseline, 17 male) in a longitudinal study design the association between accumulation of amyloid over a five to six year period, measured using PET, and functional changes in the language network measured over the same time period using task-related functional MRI. In the same participants, we also determined the association between the longitudinal functional MRI changes and a cross-sectional measure of tau load as measured with 18F-AV1451 PET. As predicted, the principal change occurred in posterior temporal cortex: In the cortex surrounding the right superior temporal sulcus, the response amplitude during the associative-semantic versus visuoperceptual task increased over time as amyloid load accumulated (Pcorrected = 0.008). In a whole-brain voxelwise analysis, amyloid accumulation was also associated with a decrease in response amplitude in the left inferior frontal sulcus (Pcorrected = 0.009) and the right dorsomedial prefrontal cortex (Pcorrected = 0.005). In cognitively intact older adults, cross-sectional tau load was not associated with longitudinal changes in fMRI response amplitude. Our findings confirm the central role of the neocortex surrounding the posterior superior temporal sulcus as the area of predilection within the language network in the earliest stages of Alzheimer’s disease. Amyloid accumulation has an impact on cognitive brain circuitry in the asymptomatic phase of Alzheimer’s disease.

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Neuromodulation in Post-stroke Aphasia Treatment

Cited by 26 publications

References 69 publications

Effectiveness of noninvasive brain stimulation in the treatment of anxiety disorders: a meta-analysis of sham or behaviour-controlled studies

Effectiveness of noninvasive brain stimulation in the treatment of anxiety disorders: a meta-analysis of sham or behaviour-controlled studies

Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study

Changes in the language system as amyloid-β accumulates

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