Neuromodulatory Activity of Dietary Phenolics Derived from <i>Corchorus olitorius</i> L.

Wagdy, Reham; Abdel‐Kader, Reham M.; El‐Khatib, Ahmed H.; Linscheid, Michael; Hamdi, Nabila; Handoussa, Heba

doi:10.1111/1750-3841.14587

Cited by 10 publications

(14 citation statements)

References 65 publications

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“…(Duncan et al., 2020; Mamat et al., 2018; Salami et al., 2016; Simion et al., 2019; Topal et al., 2016; Wagdy et al., 2019; Yang, Yu, et al., 2018)…”

Section: Chemistrymentioning

confidence: 99%

Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

et al. 2021

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SUMMARY Caffeoylquinic acids (CQAs) are specialized plant metabolites we encounter in our daily life. Humans consume CQAs in mg‐to‐gram quantities through dietary consumption of plant products. CQAs are considered beneficial for human health, mainly due to their anti‐inflammatory and antioxidant properties. Recently, new biosynthetic pathways via a peroxidase‐type p‐coumaric acid 3‐hydroxylase enzyme were discovered. More recently, a new GDSL lipase‐like enzyme able to transform monoCQAs into diCQA was identified in Ipomoea batatas. CQAs were recently linked to memory improvement; they seem to be strong indirect antioxidants via Nrf2 activation. However, there is a prevalent confusion in the designation and nomenclature of different CQA isomers. Such inconsistencies are critical and complicate bioactivity assessment since different isomers differ in bioactivity and potency. A detailed explanation regarding the origin of such confusion is provided, and a recommendation to unify nomenclature is suggested. Furthermore, for studies on CQA bioactivity, plant‐based laboratory animal diets contain CQAs, which makes it difficult to include proper control groups for comparison. Therefore, a synthetic diet free of CQAs is advised to avoid interferences since some CQAs may produce bioactivity even at nanomolar levels. Biotransformation of CQAs by gut microbiota, the discovery of new enzymatic biosynthetic and metabolic pathways, dietary assessment, and assessment of biological properties with potential for drug development are areas of active, ongoing research. This review is focused on the chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity recently reported for mono‐, di‐, tri‐, and tetraCQAs.

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“…(Duncan et al., 2020; Mamat et al., 2018; Salami et al., 2016; Simion et al., 2019; Topal et al., 2016; Wagdy et al., 2019; Yang, Yu, et al., 2018)…”

Section: Chemistrymentioning

confidence: 99%

Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

et al. 2021

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“…Dietary polyphenols are gaining scientific attention for their protective effects against degenerative diseases and cognitive decline due to its antioxidants properties [ 137 ]. A group of researchers revealed that hydroalcohol extract of C. olitorius leaves had inhibitory effects on neuroinflammation in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation [ 138 ]. They characterized 25 metabolites, and one of the major constituents (5.7%) was 1,5-dicaffeoylquinic acid, which significantly protected microglia from H 2 O 2 -induced cytotoxicity.…”

Section: Biological Activitymentioning

confidence: 99%

“… [ 148 ] Neuromodulatory activity C. olitorius Leaf Ethanol Extracts significantly correlated with improved cognitive function and reduced neurodegeneration induced by LPS. [ 138 ] Phytoalexin activity C. olitorius Fresh young leaf 95% ethanol Isolated stress metabolites and volatile compounds had good activity against the microorganisms. Antifungal substances are released or fungioxic compounds are synthesized in response to infection or injury.…”

Section: Biological Activitymentioning

confidence: 99%

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

et al. 2022

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Plant bioactive compounds have gained global significance in terms of both medicinal and economic ramifications due to being easily accessible and are believed to be effective with fewer side effects. Growing relevant clinical and scientific evidence has become an important criterion for accepting traditional health claims of medicinal plants and also supports the traditional uses of Corchorus as folk medicine. C. capsularis and C. olitorius have broad applications ranging from textile to biocomposite, and young leaves and shoots are used as healthy vegetables and have long been used as traditional remedies for fever, ascites, algesia, liver disorders, piles, and tumors in many cultures. This review systematically summarized and emphasized the nutritional attributes, mostly available bioactive compounds, and biological and potential pharmaceutical properties of C. capsularis and C. olitorius, disclosed to users and non-users. Results suggest that various phytochemicals such as cardiac glycosides, phenols, flavonoids, sterols, lipids, and fatty acids were found or analytically identified in different plant parts (leaf, stem, seed, and root), and many of them are responsible for pharmacological properties and their antitumor, anticancer, antioxidant, antinociceptive, anti-inflammatory, analgesic, antipyretic, antiviral, antibacterial, anticonvulsant, antidiabetic and antiobesity, and cardiovascular properties help to prevent and cure many chronic diseases. In addition to their use in traditional food and medicine, their leaves have also been developed for skin care products, and some other possible uses are described. From this review, it is clear that the isolated compounds of both species have great potential to prevent and treat various diseases and be used as functional foods. In conclusion, this comprehensive review establishes a significant reference base for future research into various medical and functional food applications.

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“… 49 Additionally, 3,4-dicaffeoylquinic acid had a powerful antioxidant activity besides neuroprotective action. 50 Terpenoids are widely distributed in C. olitorius , with 18 terpenoidal compounds have been reported. Phytol diterpenoidal compounds showed antimicrobial, antioxidant and anticancer activities.…”

Section: Natural Products From C Olitoriusmentioning

confidence: 99%

Pharmacological and phytochemical biodiversity of Corchorus olitorius

et al. 2022

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Neuromodulatory Activity of Dietary Phenolics Derived from Corchorus olitorius L.

Cited by 10 publications

References 65 publications

Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

A Comprehensive Review of C. capsularis and C. olitorius: A Source of Nutrition, Essential Phytoconstituents and Pharmacological Activities

Pharmacological and phytochemical biodiversity of Corchorus olitorius

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