2014
DOI: 10.1371/journal.pone.0102240
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Neuromodulatory Control of a Goal-Directed Decision

Abstract: Many cost-benefit decisions reduce to simple choices between approach or avoidance (or active disregard) to salient stimuli. Physiologically, critical factors in such decisions are modulators of the homeostatic neural networks that bias decision processes from moment to moment. For the predatory sea-slug Pleurobranchaea, serotonin (5-HT) is an intrinsic modulatory promoter of general arousal and feeding. We correlated 5-HT actions on appetitive state with its effects on the approach-avoidance decision in Pleur… Show more

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Cited by 17 publications
(20 citation statements)
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“…The storage of the nutritional state in an isolated nervous system has been demonstrated earlier in Lymnaea (Elliott and Andrew, 1991;Hernádi et al, 2004) and other molluscs (Gillette, 2006;Hirayama and Gillette, 2012;Hirayama et al, 2014). The results of the present study agree with these previous studies and show that 24-36 h of food deprivation causes an excitation of CGC and PeA serotonergic neurons in intact ganglia (isolated CNS).…”
Section: Storage Of the Behavioural State In Completely Isolated Neuronssupporting
confidence: 92%
See 1 more Smart Citation
“…The storage of the nutritional state in an isolated nervous system has been demonstrated earlier in Lymnaea (Elliott and Andrew, 1991;Hernádi et al, 2004) and other molluscs (Gillette, 2006;Hirayama and Gillette, 2012;Hirayama et al, 2014). The results of the present study agree with these previous studies and show that 24-36 h of food deprivation causes an excitation of CGC and PeA serotonergic neurons in intact ganglia (isolated CNS).…”
Section: Storage Of the Behavioural State In Completely Isolated Neuronssupporting
confidence: 92%
“…The role of serotonin in mediating a hunger/feeding behavioural state has been suggested and proved in many invertebrates (Horvitz et al, 1982;Lent and Dickinson, 1988;Sakharov, 1990a;Sakharov, 1990b;Palmer and Kristan, 2011;Donnelly et al, 2013), including molluscs (Alania et al, 2004;Hernádi et al, 2004;Gillette, 2006;Hirayama and Gillette, 2012;Hirayama et al, 2014;Dyakonova, 2014). In this study, we utilized the advantages of the mollusc Lymnaea stagnalis to elucidate how a hunger behavioural state is represented at a single serotonergic cellular level.…”
Section: Introductionmentioning
confidence: 99%
“…42 for discussion). Unlike the giant cerebral serotonergic cells whose involvement in the control of feeding behavior has been described in many species434445 including Helix 46, the behavioral role of pedal serotonergic neurons has not been extensively investigated.…”
Section: Discussionmentioning
confidence: 99%
“…This threshold might well be a variable influenced by reproductive state, health, or neuromodulatory inputs from other neuronal networks (cf Hirayama et al, 2014), but is set as a simple constant here.…”
Section: Methodsmentioning
confidence: 99%