Neuromodulatory Effect of BDNF in Spinal Cord Injury

Abstract

The neuromodulatory effect of brain-derived neurotrophic factor (BDNF) in spinal cord injury (SCI) is a topic of significant interest. BDNF, a neurotrophic factor, plays a crucial role in promoting neuronal survival, axonal growth, and synaptic plasticity in the central nervous system. In SCI, BDNF has been shown to enhance the survival of injured neurons and stimulate axonal growth through the activation of downstream signaling pathways. Additionally, BDNF exhibits potent anti-inflammatory effects, reducing neuroinflammation and secondary damage. The timing and duration of BDNF administration are critical, with early intervention showing better outcomes. However, the optimal dosage and frequency of BDNF administration remain to be determined. Further research is needed to fully understand the potential of BDNF as a therapeutic agent for enhancing functional recovery and promoting neuroplasticity in individuals with SCI.