Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy

Yıldız, Mustafa; Çelik, Hamit; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, İbrahim; Genç, Aydın; Kandemir, Özge

doi:10.1016/j.neuro.2022.04.002

Cited by 36 publications

(14 citation statements)

References 66 publications

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“…It has been previously reported that oxidative stress, which develops due to excessive increase in reactive oxygen species, is the basic mechanism of many toxic compounds [21][22][23][24][25]. There is evidence of increased oxidative stress in chronic toxicity of several OP compounds, including MLT [19,26,27].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Gür

Kandemir

2022

Türk Doğa Ve Fen Dergisi

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Malathion (MLT) is an important environmental pollutant in the organophosphate class. Rutin (RUT), on the other hand, is one of the flavonoid family members whose effectiveness against various toxic agents has been extensively studied. In the present study, the effects of MLT and RUT treatments on oxidative stress, apoptosis and metalloproteinases in lung tissues of rats were investigated. In the study, MDA, GSH, Nrf2, HO-1, MMP2, MMP9 and caspase-3 levels in lung tissues were analyzed by biochemical or RT-PCR method after rats received MLT and/or RUT treatment for 28 days. The data showed that MLT-induced MDA levels decreased after RUT treatment. In addition, it was determined that Nrf2 and HO-1 mRNA transcript levels and GSH levels suppressed by MLT approached the control group levels after RUT treatment. MLT up-regulated the expression of metalloproteinases (MMP2 and MMP9) in lung tissues, while RUT down-regulated the expression of these genes. In addition, it was observed that MLT triggered caspase-3 expression, while RUT exerted an anti-apoptotic effect by suppressing caspase-3. As a result, it was determined that while MLT showed toxic effects in the lung tissues of rats through oxidative stress, apoptosis and metalloproteinases, RUT could alleviate these toxic effects.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Gür

Kandemir

2022

Türk Doğa Ve Fen Dergisi

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“…Oxidative stress causes NF‐κB activation which leads to increased expression of pro‐inflammatory cytokines, thus triggering the inflammatory process 30,39–41 . The interaction between ER stress and inflammation has been extensively studied in cell types with metabolic or immune functions, and inflammation has been associated with unfolded protein response (UPR) activation to promote disease development 38 .…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress causes NF-κB activation which leads to increased expression of pro-inflammatory cytokines, thus triggering the inflammatory process. 30,[39][40][41] The interaction between ER stress and inflammation has been extensively studied in cell types with metabolic or immune functions, and inflammation has been associated with unfolded protein response (UPR) activation to promote disease development. 38 In many previous studies, it has been reported that organophosphate compounds, including MLT, trigger inflammation by increasing the expression of pro-inflammatory cytokines in various tissues.…”

Section: Discussionmentioning

confidence: 99%

Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model

Gür

Kandemir

2022

Environmental Toxicology

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Widely used malathion (MLT) causes environmental pollution, leading to toxicity in many living things, including humans. Rutin (RUT) is a flavonoid with various biological properties. In the present study, the protective effects of rutin against liver and kidney toxicity caused by malathion were investigated. In the study, MLT (100 mg/ kg) and RUT (50 or 100 mg/kg) were administered to rats alone or in combination for 28 days. Then, oxidative stress, inflammation, endoplasmic reticulum stress (ERS), apoptosis, and autophagy markers in liver and kidney tissues were analyzed by biochemical and molecular methods. The results showed that MLT caused oxidative stress in both tissues, while RUT showed antioxidant properties and protected these tissues from oxidative damage. Moreover, MLT upregulated the expressions of ATF-6, PERK, IRE1, GRP78, and CHOP, leading to ERS. However, RUT alleviated ER stress and suppressed these markers. The study also found that MLT increased inflammatory, apoptotic, and autophagic markers. All these factors affected liver and kidney functions and caused an increase in plasma ALT, AST, urea, and creatinine levels. On the other hand, it has been observed that RUT may protect liver and kidney tissues from the destructive effect of MLT by showing anti-inflammatory, antiapoptotic, and anti-autophagic properties. Thus, it was determined that ALT, AST, urea, and creatinine levels decreased after RUT treatment. As a result, it was observed that MLT had a toxic effect on the liver and kidney tissues of rats, and it was determined that this toxicity could be alleviated by RUT treatment.

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“…Citrus fruits are a source of the bioflavonoid hesperidin which displays antioxidant, anti-inflammatory, sedative and anti-convulsant properties and can improve mood through modulation of neuroinflammation and brain plasticity [ 43 , 104 , 105 ]. In addition, hesperidin has been shown to be effective in reducing inflammation caused by stress.…”

Section: Therapeutic Potential Of Microalgae In Sleep and Mood Regula...mentioning

confidence: 99%

Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges

2022

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Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review explores the relevance of microalgae bioactives as a sustainable source of valuable phytochemicals that can contribute positively to mood and sleep disorders. Microalgae species producing these compounds are also catalogued, thus creating a useful reference of the state of the art for further exploration of this proposed approach. While we highlight possibilities awaiting investigation, we also identify the associated issues, including minimum dose for therapeutic effect, bioavailability, possible interactions with conventional treatments and the ability to cross the blood brain barrier. We conclude that physical and biological functionalization of microalgae bioactives can have potential in overcoming some of these challenges.

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Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy

Cited by 36 publications

References 66 publications

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Evaluation of the Levels of Metalloproteinases as well as Markers of Oxidative Stress and Apoptosis in Lung Tissues After Malathion and Rutin Administrations to Rats

Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model

Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges

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