Neuromolecular and behavioral effects of cannabidiol on depressive-associated behaviors and neuropathic pain conditions in mice

Shen, Ziyi; Bao, Nana; Chen, Junwen; Tang, Ming; Yang, Linfeng; Yang, Yang; Zhang, Haoran; Han, Jingyu; Yu, Peilu; Zhang, Shushan; Yang, Hanfeng; Jiang, Guohui

doi:10.1016/j.neuropharm.2024.110153

Neuropharmacology

2024

DOI: 10.1016/j.neuropharm.2024.110153

|View full text |Cite

Neuromolecular and behavioral effects of cannabidiol on depressive-associated behaviors and neuropathic pain conditions in mice

Ziyi Shen,

Nana Bao,

Junwen Chen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cross-disease drug discovery based on bioinformatics and virtual screening: Study of key genes in Alzheimer’s disease and ovarian cancer

Shen,

Song,

Wang

et al. 2025

Gene

View full text Add to dashboard Cite

Cross-disease drug discovery based on bioinformatics and virtual screening: Study of key genes in Alzheimer’s disease and ovarian cancer

Shen,

Song,

Wang

et al. 2025

Gene

View full text Add to dashboard Cite

FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer

Song,

Wang,

Hua

et al. 2024

Cell Death Dis

View full text Add to dashboard Cite

Breast cancer is one of the most prevalent and diverse malignancies, and, with global cases increasing, the need for biomarkers to inform individual sensitivity to chemotherapeutics has never been greater. Our retrospective clinical analysis predicted that the expression of the fragile site-associated tumor suppressor (FATS) gene was associated with the sensitivity of breast cancer to neoadjuvant chemotherapy with paclitaxel. In vitro experiments subsequently demonstrated that FATS significantly increased the inhibitory effects of paclitaxel on breast cancer cells’ migration, growth, and survival. An interaction screen revealed that FATS interacted with MYH9 and promoted its degradation via the ubiquitin-proteasome pathway, thereby downregulating Wnt signaling. By overexpressing FATS and MYH9, we demonstrated that FATS enhanced paclitaxel-induced apoptosis in breast cancer cells by degrading MYH9 to downregulate the Wnt pathway. We also demonstrated in a mouse xenograft model that FATS significantly increased the chemosensitivity of breast cancer cells to paclitaxel in vivo. This study presents a new mechanism by which FATS interacts with MYH9 to suppress the Wnt/β-catenin signaling pathway and induce apoptosis, thus enhancing the sensitivity of breast cancer cells to paclitaxel chemotherapy. The results also propose novel biomarkers for predicting breast cancer sensitivity to neoadjuvant chemotherapy with paclitaxel. Finally, we provide in vivo evidence that the combination of paclitaxel with IWR-1, a novel Wnt pathway inhibitor, synergistically suppresses breast cancer growth, laying the foundation for future trials with this drug combination. These results therefore provide a number of potential solutions for more precise treatment of patients with breast cancer in the future.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Neuromolecular and behavioral effects of cannabidiol on depressive-associated behaviors and neuropathic pain conditions in mice

Cited by 2 publications

References 67 publications

Cross-disease drug discovery based on bioinformatics and virtual screening: Study of key genes in Alzheimer’s disease and ovarian cancer

Cross-disease drug discovery based on bioinformatics and virtual screening: Study of key genes in Alzheimer’s disease and ovarian cancer

FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer

Contact Info

Product

Resources

About