Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification

Slovis, Julia; Bach, Ashley; Beaulieu, Forrest; Zuckerberg, Gabe; Topjian, Alexis; Kirschen, Matthew

doi:10.1007/s12028-023-01685-6

Cited by 8 publications

(4 citation statements)

References 213 publications

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“…Thorough testing is imperative to ensure their clinical utility, accuracy, and reliability 16) . Slovis 17) emphasizes the necessity for substantial clinical investigations to validate the usefulness of biomarkers in improving patient outcomes and providing significant insights for medical decision-making. Mussack et al 10) investigated the blood levels of S-100B and Interleukin-8 in individuals experiencing cardiac arrest or traumatic brain injury.…”

Section: Exploring the Role Of Biomarkersmentioning

confidence: 99%

“…Echocardiography enables real-time monitoring of cardiac dynamics and identification of anomalies in heart anatomy and function. Combining these diagnostic techniques establishes a comprehensive framework for detecting cardiac arrest in TBI patients, facilitating prompt interventions and tailored treatment strategies based on individual patient conditions 9,[17][18][19][20] . The survival rate is associated with the GCS score and pupil reactivity.…”

Section: Diagnostic Approachesmentioning

confidence: 99%

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Cardiac Arrest in Traumatic Brain Injury

Atallah,

Rahman,

Chaurasia

et al. 2024

J Neurointensive Care

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Traumatic brain injury (TBI) is a significant global health concern with substantial contributions to illness and mortality rates. This study aims to scrutinize the intricate interplay between neurological and circulatory abnormalities post-TBI, particularly focusing on the challenge posed by cardiac arrest in TBI patients. The study employs a comprehensive approach, utilizing clinical assessments, electrocardiograms, intracranial pressure monitoring, brain imaging, and biomarker utilization. It explores the effectiveness of these methods in detecting cardiac arrest in TBI patients. Additionally, the research delves into resuscitation techniques, hemodynamic stabilization, intracranial pressure management, and neurological enhancement as potential therapeutic modalities. The results highlight the importance of prompt initiation of cardiopulmonary resuscitation and adherence to advanced cardiac life support protocols in TBI patients with cardiac arrest. Prognostic factors such as injury severity, response time, effectiveness of resuscitation interventions, and pre-existing medical conditions are identified as crucial elements in predicting cardiac arrest outcomes in TBI patients. The study concludes by emphasizing the critical necessity of a comprehensive approach to understand and manage the complex relationship between cardiac arrest and TBI. Incorporating scientific discoveries, clinical perspectives, and technological advancements, the review underscores the importance of addressing this multifaceted medical challenge through a thorough analysis and effective management strategies.

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Section: Exploring the Role Of Biomarkersmentioning

confidence: 99%

Section: Diagnostic Approachesmentioning

confidence: 99%

Cardiac Arrest in Traumatic Brain Injury

Atallah,

Rahman,

Chaurasia

et al. 2024

J Neurointensive Care

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“…Monitoring for neurologic injury on ECMO and after cardiac arrest is challenging due to degree of illness that may preclude neurologic exam, difficulty in transporting patients for imaging and limitations of bedside monitoring capability. 14 , 15 , 16 , 17 Brain injury blood-based biomarkers are a potential modality to monitor and direct neuroprotective therapy for patients on ECMO and following cardiac arrest. 18 , 19 , 20 …”

Section: Introductionmentioning

confidence: 99%

Higher levels of brain injury biomarker tau are associated with unfavorable outcomes in patients supported with ECMO following cardiac arrest

Schwartz,

Ng,

Roem

et al. 2024

Resuscitation Plus

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“…So, the question that arises from these data are, what approach should practitioners take in neuroprognostication? For example, is a multimodal neuromonitoring approach warranted in all comatose children after CA, which would include repeated neurologic examinations, early continuous electroencephalography (up to 24–48 hr post-CA), and brain MRI on days 3–5 post-CA (8, 10). Of note, in this new cohort, brain MRI was performed in only 34% of children who died after WLST.…”

mentioning

confidence: 99%