Neuromuscular Blockade with Vecuronium in Paediatric Patients with Burn Injury

Mills, A. K.; Martyn, J. A. J.

doi:10.1097/00132586-199008000-00049

Cited by 3 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mills and Martyn demonstrated that ED 50 and ED 95 of vecuronium were significantly (97.5±20.3 s) (P< 0.01). Our results are also in keeping with the results of another study with vecuronium increased in burned children (2). But this study did not examine the recovery from neuromuscular (10).…”

Section: Introduction Materials and Methodssupporting

confidence: 90%

“…Thermal injury is known to produce resistance to The study was approved by the Hospital's Ethics nondepolarizing muscle relaxants (1)(2)(3)(4)(5)(6)(7). The neuro-Committee and written informed consent was muscular responses to vecuronium in children with obtained from parents.…”

Section: Introduction Materials and Methodsmentioning

confidence: 99%

“…The neuro-Committee and written informed consent was muscular responses to vecuronium in children with obtained from parents. Sixteen burned children thermal injury has been delineated at the effective undergoing excision and autograft surgery and 10 doses for 50% and 95% suppression of twitch tension normal unburned control children were included in (ED 50 and ED 95 ) (2). The goal of our study was to this prospective study extending over 16 months.…”

Section: Introduction Materials and Methodsmentioning

confidence: 99%

“…Burn injuries result in major patho-simultaneous EMG (11). Resistance to NDMR usually develops in patients physiological changes with an alteration of cardiovascular, pulmonary, hepatic and renal with more than 20% burn and one week after injury (2,5,12). Rarely, some patients show hyposensitivity functions, as well as modifications in the pharmacokinetics and the pharmacodynamic to the effects of NDMRs by three days (7).…”

Section: Introduction Materials and Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Resistance to vecuronium in burned children

Uyar¹,

Hepağuşlar²,

Ugur³

et al. 1999

Pediatric Anesthesia

View full text Add to dashboard Cite

We compared the time-course of action of vecuronium in 16 burned children undergoing excision and autograft surgery with that of ten unburned children. Standardized anaesthesia was induced with thiopentone 4-6 mg kg-1 and fentanyl 1 microgram.kg-1 and maintained with endtidal 1-1.5% isoflurane in N2O/O2. Neuromuscular responses were monitored by acceleromyography (TOF-Guard, Organon Teknika/Biometer) with supramaximal train-of-four (TOF) stimuli delivered every 15s. Vecuronium 0.1 mg kg-1 was administered intravenously. Onset was recorded as the time, in seconds, between the initial bolus of vecuronium and a decline in the first twitch of TOF (T1) to 5% of control. The times for the recovery of T1-25%, 50% and 75% of control, recovery index and the recovery of TOF 25% and 50% were recorded. Onset of action was found slower in burned patients (189 +/- 70 s) than in control (98 +/- 20 s) (P < 0.01). Recovery times of T1(25), T1(50), T1(75), TOF25 and TOF50 were significantly shorter in burned patients indicative of decreased sensitivity to vecuronium (P < 0.01).

show abstract

Section: Introduction Materials and Methodssupporting

confidence: 90%

Section: Introduction Materials and Methodsmentioning

confidence: 99%

Section: Introduction Materials and Methodsmentioning

confidence: 99%

Section: Introduction Materials and Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Resistance to vecuronium in burned children

Uyar¹,

Hepağuşlar²,

Ugur³

et al. 1999

Pediatric Anesthesia

View full text Add to dashboard Cite

show abstract

“…Clinically, there is an increased requirement for d-TC a n d o t h e r nondepolarizing muscle relaxants. 6,18,20,22,23,25,26 T h ere are some discrepancies, however, concerning the onset of resistance in rats and humans. Dwerstag et a1.,6 reported that resistance to atracurium in humans with a 33% burn was maximal at 15-40 days and attenuated by 100 days.…”

Section: Discussionmentioning

confidence: 99%

Burn injury—induced nicotinic acetylcholine receptor changes on muscle membrane

Ward

Martyn

1993

Muscle and Nerve

View full text Add to dashboard Cite

Patients with thermal injury show pharmacological responses akin to those seen following denervation of motor nerve where there is an increase in the number of muscle-type acetylcholine receptors (AChR). This study in the rat, examined the effect of 20%, 30%, and 50% body surface area burn injury on gastrocnemius and diaphragm AChR number, quantitated by [125I]alpha-bungarotoxin (alpha-BGT). Pharmacodynamic responses to D-tubocurarine were evaluated in the gastrocnemius muscle. AChR from gastrocnemius muscle were significantly increased in all burn groups at 14 days after burn. After 28 days, the AChR had returned to control in the 20% and 30% burn groups, but persisted in the 50% burn group. AChR from diaphragm did not show significant changes between groups. Resistance to D-tubocurarine was not seen in burn groups compared with controls. Burn trauma causes increases of AChR at sites distant from the area of injury. Diaphragm muscle may be less sensitive than gastrocnemius to mediators which upregulate AChR.

show abstract

Toxic Inhalational Exposures

Chen

Malli

Maslove

et al. 2012

J Intensive Care Med

View full text Add to dashboard Cite

Respirable toxicants are a spectrum of irritant and nonirritant gases, vapors, fumes, and airborne particles that can be entrained into the body through the respiratory tract, resulting in exposures that cause pulmonary injury and/or systemic disease. Sources of respirable toxicants include structural fires, industrial accidents, domestic mishaps, and intentional releases of injurious agents on the battleground (warfare) or in civilian settings (acts of terrorism). Acute toxic inhalational exposures may result in respiratory failure, multisystem organ dysfunction, and death. Management of victims includes assessment and protection of the airway, monitoring and treatment of systemic toxicity, and delivery of exposure-specific and nonspecific therapies that improve outcomes. Treatments may include antidotes, hyperbaric oxygen, and other nonspecific life-supporting interventions.

show abstract

Neuromuscular Blockade with Vecuronium in Paediatric Patients with Burn Injury

Cited by 3 publications

References 13 publications

Resistance to vecuronium in burned children

Resistance to vecuronium in burned children

Burn injury—induced nicotinic acetylcholine receptor changes on muscle membrane

Toxic Inhalational Exposures

Contact Info

Product

Resources

About