Neuromuscular blocking activity of methanolic extract of Piper sarmentosum leaves in the rat phrenic nerve-hemidiaphragm preparation

Chemical constituents and bioactivity of Piper sarmentosum

“…in rats (Peungvicha et al, 1998) while the methanolic extract of the leaves was found to possess a marked neuromuscular blocking activity in rat phrenic nerve-hemidiaphragm preparation (Ridtitid et al, 1998). In addition, the chloroform and methanol extracts of the leaves showed considerable antiplasmodial activity against Plasmodium falciparum and Plasmodium berghei parasites (Najib Nik et al, 1999).…”

A review of the literature and latest advances in research ofPiper sarmentosum

“…Methanol extracts of leaves of the plant in a concentration range 3.2, 4, 4.8 and 6.4 mg/mL have exhibited a transient increase in twitch tension of rat phrenic nerve hemidiaphragm preparation which is followed by a marked dose-related neurally evoked twitch depression with EC 50 at 4.07 mg/mL (Ridtitid et al, 1998).…”

Review on the ethnomedicinal, phytochemical and pharmacological properties of Piper sarmentosum: scientific justification of its traditional use

“…From the results obtained, the activity of the CEPS L was higher as compared to the activity of both markers and it showed significant antiangiogenic activities with IC 50 value of 45 µg/ml. Ridtitid et al (1998) studied neuromuscular blocking activity of the methanol extract of P. sarmentosum leaves (MEPS L ) using rat phrenic nerve-hemidiaphragm preparations. The plant was collected from the Promkeeree district, Nakhornsrithamarat province, Thailand.…”