Neuromuscular characterisation in Cerebral Palsy using hybrid Hill-type models on isometric contractions

Wiedemann, Lukas; Jayaneththi, Vinura; Kimpton, Jessica; Chan, Anthony; Müller, Matthias A.; Hogan, Amy; Lim, Eewei; Wilson, Nichola; McDaid, Andrew

doi:10.1016/j.compbiomed.2018.10.027

Cited by 8 publications

(1 citation statement)

References 31 publications

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“…Neural data-driven models that use EMG as the input are an exception to this lack of neural control in driving musculoskeletal models 4 – 9 . They are beneficial for in-depth studies to quantify musculoskeletal function and control 8 via neural drive, or common synaptic input, to the spinal cord and muscles 4 .…”

Section: Introductionmentioning

confidence: 99%

Integration of neural architecture within a finite element framework for improved neuromusculoskeletal modeling

Volk

Hamilton

Hume

et al. 2021

Sci Rep

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Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurodegenerative conditions. In this study, we present a predictive NMS model that uses an embedded neural architecture within a finite element (FE) framework to simulate muscle activation. A previously developed neuromuscular model of a motor neuron was embedded into a simple FE musculoskeletal model. Input stimulation profiles from literature were simulated in the FE NMS model to verify effective integration of the software platforms. Motor unit recruitment and rate coding capabilities of the model were evaluated. The integrated model reproduced previously published output muscle forces with an average error of 0.0435 N. The integrated model effectively demonstrated motor unit recruitment and rate coding in the physiological range based upon motor unit discharge rates and muscle force output. The combined capability of a predictive NMS model within a FE framework can aid in improving our understanding of how the nervous and musculoskeletal systems work together. While this study focused on a simple FE application, the framework presented here easily accommodates increased complexity in the neuromuscular model, the FE simulation, or both.

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