Neuromuscular disease in patients with steatorrhoea.

Vitamin E: An overview of major research directions

“…A relationship between neurologic dysfunction and vitamin E deficiency in patients with chronic steatorrhea was first described by Binder et al (1967). Harding et al described a young woman with spinocerebellar degeneration thought to be due to a selective defect in vitamin E absorption, without any evidence of fat malabsorption (Harding et al, 1985), and similar findings were reported later in several further patients.…”

“…Plant derived oils represent the major sources of vitamin E in the human diet, and because these oils contain the four tocopherols in different relative amounts, the overall intake of each vitamin E analogue depends in large Table 1 A selection of seminal discoveries on vitamin E and their associated influence on major research directions 1922 Discovery of vitamin E as an dietary factor essential for reproduction in rats Bishop, 1922) 1931 Antioxidant function of vitamin E (Cummings and Mattill, 1931), and biochemical characterisation (Tappel and Zalkin, 1960, Tappel, 1953, 1954, 1955, proposal of regeneration of vitamin E by vitamin C and in vitro demonstration (Packer et al, 1979;Tappel et al, 1961), regeneration of vitamin E by the mitochondrial electron transport chain (Maguire et al, 1989(Maguire et al, ) 1967 Discovery of disease preventing activities: prevention of cardiovascular disease (Vogelsang and Shute, 1946), and of neurological symptoms associated with vitamin E deficiency (Binder et al, 1967;Harding et al, 1985), first epidemiological studies showing protective effects against cardiovascular disease (Gey, 1989;Gey et al, 1991Gey et al, ) 1956 Discovery of metabolites (Simon metabolites) (Simon, 1956), and later carboxyethyl hydroxychromans (CEHCs) (Chiku et al, 1984;Schultz et al, 1995;Wechter et al, 1996), induction of cytochrome P450 (CYP) drug metabolizing enzymes by vitamin E via pregnane X receptor (PXR) (Landes et al, 2003(Landes et al, ) 1988 Inhibition of protein kinase C by vitamin E (Boscoboinik et al, 1992;Mahoney and Azzi, 1988), stimulating research about non-antioxidant effects of vitamin E analogues on signal transduction and gene expression. Modulation of the expression of individual genes (Ricciarelli et al, 1999(Ricciarelli et al, , 2000Teupser et al, 1999), and of genome-wide gene networks as assayed by gene arrays …”

Spinocerebellar degeneration secondary to chronic intestinal malabsorption: A vitamin E deficiency syndrome

“…Several of these cases had clinical syndromes similar to that described here; these may have been due to vitamin E deficiency, although the neurological disease was often attributed to a lack of vitamin BIZ. Binder et al [5] reported four patients with neurological disease and steatorrhea. Two of them were similar clinically to our cases and had low serum vitamin E concentrations.…”

Generalized Myokymia as a Unique Association with Gluten-Sensitive Enteropathy

“…Clinical progression of neurologic complications despite histologic improvement on jejunal biopsy has also been reported previously [2,3]. Binder et al [5] suggested that patients who do not respond to a gluten-free diet are at a greater risk of developing neurologic complications of GSE. Additionally, a long delay between clinical neurologic stabilization, or improvement, has also been reported [2,6].…”