Neuromuscular electrical stimulation exercise: a potential alternative to conventional exercise in the management of type 2 diabetes

Giggins, Oonagh M.; Crowe, Louis; Coughlan, Garrett F.; Caulfield, Brian

doi:10.15277/bjd.2017.127

Cited by 6 publications

(11 citation statements)

References 23 publications

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“…Our study shows no change in body composition and leg muscle mass which is in agreement with previous research using DXA, indicating NMES does not change muscle mass after the intervention; however, it is in disagreement with other research ( 17 , 26 ) in SCI populations after 10 weeks of NMES. Griffin et al 2008 showed an increase in muscle power and work and a 4% increase in lean muscle mass by DXA using cycling functional electrical stimulation for 10 weeks in a SCI population ( 26 ).…”

Section: Discussionsupporting

confidence: 77%

“…It has been well established that muscle contraction effectively increases glucose uptake via an insulin-independent signaling pathway ( 14 , 15 ). Human studies on the effects of NMES-induced muscle contraction on insulin sensitivity are limited to the population with T2DM ( 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ) and spinal cord injury (SCI) ( 24 , 25 , 26 , 27 ). Two studies conducted in healthy individuals reported an increased acute glucose disposal rate measured by a hyperinsulinemic–euglycemic clamp ( 28 , 29 ).…”

Section: Introductionmentioning

confidence: 99%

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Four weeks of electrical stimulation improves glucose tolerance in a sedentary overweight or obese Hispanic population

Galvan

Sanchez

McAinch

et al. 2022

Endocrine Connections

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Introduction/Purpose: Most U.S. adults (54%) do not meet minimum exercise recommendations by American College of Sports Medicine (ACSM). Neuromuscular electrical stimulation (NMES) is a novel alternate strategy to induce muscle contraction. However, effectiveness of NMES to improve insulin sensitivity and energy expenditure is unclear. The purpose of this study was to investigate the effects of four weeks of NMES on glucose tolerance in a sedentary overweight or obese population. Methods: Participants (n=10; age: 36.8 ± 3.8 years; BMI=32 ± 1.3 kg/ m2) were randomized into either control or NMES group. All participants received bilateral quadriceps stimulation (12 sessions; 30 minutes/session; 3 times/week at 50 Hz and 300 µs pulse width) altering pulse amplitude to either provide low intensity sensory level (control; tingling sensation) or at high intensity neuromuscular level (NMES; maximum tolerable levels with visible muscle contraction). Glucose tolerance was assessed by three-hour oral glucose tolerance test (OGTT), substrate utilization was measured by indirect calorimetry and body composition via dual X-ray absorptiometry at baseline and after four weeks of NMES intervention. Results: Control and NMES groups had comparable fasting blood glucose, glucose tolerance, substrate utilization, and muscle mass at baseline. Four weeks of NMES resulted in a significant improvement in glucose tolerance measured by OGTT, whereas no change was observed in control group. There was no change in substrate utilization and in muscle mass in both control and NMES groups. Conclusion: NMES is a novel and effective strategy to improve glucose tolerance in an at-risk overweight or obese sedentary population.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Four weeks of electrical stimulation improves glucose tolerance in a sedentary overweight or obese Hispanic population

Galvan

Sanchez

McAinch

et al. 2022

Endocrine Connections

View full text Add to dashboard Cite

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“…Long-term studies showed improvements in insulin sensitivity, glycemic control or physical performance after several weeks of local or whole-body EMS [34][35][36][37][38] with both active and passive application.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute Resistance Exercise with and without Whole-Body Electromyostimulation and Endurance Exercise on the Postprandial Glucose Regulation in Patients with Type 2 Diabetes Mellitus: A Randomized Crossover Study

et al. 2021

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Background: Long hyperglycemic episodes trigger complications in type 2 diabetes mellitus (T2DM) patients. Postprandial glucose excursions can be reduced by acute physical activity. However, it is not yet clear which type of exercise has the best effect on postprandial glucose levels. Methods: Six T2DM patients participated in three 20-min moderate-intensity exercise sessions after breakfast in a randomized order: resistance exercise with whole-body electromyostimulation (WB-EMS), resistance exercise without electromyostimulation (RES) and cycling endurance exercise (END). A continuous glucose monitoring system recorded glucose dynamics. Results: Postprandially-increased glucose levels decreased in all cases. Time to baseline (initial value prior to meal intake) was quite similar for WB-EMS, RES and END. Neither glucose area under the curve (AUC), nor time in range from the start of the experiment to its end (8 h later) differed significantly. A Friedman analysis of variance, however, revealed an overall significant difference for AUC in the post-exercise recovery phase (END seems to have superior effects, but post-hoc tests failed statistical significance). Conclusions: There are no notable differences between the effects of the different types of exercise on glucose levels, especially when comparing values over a longer period of time.

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“…In the present study, the HbA1c level reduced following 8 weeks of NMES, but not significantly. However, the results of previous studies on the effect of NMES on HbA1c levels in patients with type-2 diabetes were contradictory [ 9 , 15 , 23 , 24 ]. Louis Crow et al showed that 8 weeks of electrical stimulation reduced HbA1c levels significantly in men with type-2 diabetes [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…This before-after, single-group, clinical trial was conducted at the Amirkola Children’s Hospital in Babol, Iran from September 2020 to February 2021. Considering the decrease of 1.5 units of FBS after the intervention compared to before [ 9 ], the effect size of 0.52 at the confidence level of 95%, and the power of 80%, the sample size was determined to be 32. Consequently, with the assumption of 10% drop, 35 children and adolescents were meant to be included in the study, which were later reduced to 29 during the study with the permission of the University Research Council due to the critical COVID-19 conditions.…”

Section: Methodsmentioning

confidence: 99%

The effect of neuromuscular electrical stimulation on serum glucose levels in children and adolescents with type-1 diabetes mellitus: a single group clinical trial

et al. 2022

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Background This study aimed to evaluate the effect of Neuromuscular Electrical Stimulation (NMES) on serum glucose level in children and adolescents with type-1 diabetes. Methods This before-after, single-group, clinical trial was conducted on 29 patients with type-1 diabetes mellitus with the age range of 7–18 years. The patients underwent NMES in two 20-minute phases on the quadriceps and hamstrings muscles, three sessions per week for a period of 8 weeks. Fasting Blood Sugar (FBS), measured in two ways, by glucometer and laboratory testing, was considered as the primary outcome and the glycated hemoglobin (HbA1c) and the total daily dose (TDD) of insulin were measured as the secondary outcomes. The laboratory FBS and HbA1c were measured 1 day before the intervention (as a baseline value) and then 2 and 6 weeks after the last session of intervention. FBS by glucometer and total daily dose of insulin were recorded daily from 2 weeks before the intervention to the last day of the intervention and consequently, the weekly average of these variables was calculated and used for statistical analysis. Results The serum level of FBS (measured by glucometer) and the total daily dose of insulin reduced significantly 2 weeks after beginning of intervention. The laboratory serum level of FBS decreased significantly in the second week after the end of intervention compared to the baseline values. Although the HbA1c level decreased at follow-up period (2 and 6 weeks after the intervention), it was not significant. Conclusion It seems that 8 weeks of NMES has beneficial effects on the reduction of FBS and TDD of insulin therefore, it could be suggested as the contributory treatment in management of children and adolescents with type-1 diabetes. Trial registration The study was registered at https://fa.irct.ir/user/trial/51739/view (IRCT20100523003998N1) in date of 25/10/2020.

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Neuromuscular electrical stimulation exercise: a potential alternative to conventional exercise in the management of type 2 diabetes

Cited by 6 publications

References 23 publications

Four weeks of electrical stimulation improves glucose tolerance in a sedentary overweight or obese Hispanic population

Four weeks of electrical stimulation improves glucose tolerance in a sedentary overweight or obese Hispanic population

Effects of Acute Resistance Exercise with and without Whole-Body Electromyostimulation and Endurance Exercise on the Postprandial Glucose Regulation in Patients with Type 2 Diabetes Mellitus: A Randomized Crossover Study

The effect of neuromuscular electrical stimulation on serum glucose levels in children and adolescents with type-1 diabetes mellitus: a single group clinical trial

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