Neuromuscular Polytrauma Pain is Resolved by Macrophage COX-2 Nanoimmunomodulation
Ibdanelo Cortez,
Caitlyn M. Gaffney,
Riddhi Vichare
et al.
Abstract:Soft tissue injuries often involve muscle and peripheral nerves and are qualitatively distinct from single-tissue injuries. Prior research suggests that damaged innervation compromises wound healing. To test this in a traumatic injury context, we developed a novel mouse model of nerve and lower limb polytrauma, which features greater pain hypersensitivity and more sustained macrophage infiltration than either injury in isolation. We also show that macrophages are crucial mediators of pain hypersensitivity in t… Show more
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