Neuromuscular transmission in Ca2+-free extracellular solution

Гришин, С. Н.

doi:10.1134/s1990747816010050

Cited by 3 publications

(2 citation statements)

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“…Recently it was established that α7nAChR controls tetanic-induced ACh spillover from the neuromuscular synapse by promoting adenosine outflow from perisynaptic Schwann cells via ENT1 transporters and retrograde activation of presynaptic A 1 inhibitory receptors [ 32 ]. In 2005, studies were conducted on perineural calcium currents [ 33 ], proving a direct relationship between ATP and calcium influx, while the effect of adenosine was characterized as calcium-independent [ 34 ].…”

Section: Effects Of Atp and Adenosine On Presynaptic Currentsmentioning

confidence: 99%

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Зиганшин

Khairullin

Hoyle

et al. 2020

IJMS

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A review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synaptic processes are discussed. The contribution of purines to the processes of quantal and non-quantal secretion of acetylcholine into the synaptic cleft, as well as the influence of the postsynaptic effects of ATP and adenosine on the functioning of cholinergic receptors, are evaluated. As usual, the P2-receptor-mediated influence is minimal under physiological conditions, but it becomes very important in some pathophysiological situations such as hypothermia, stress, or ischemia. There are some data demonstrating the same in neuromuscular transmission. It is suggested that the role of endogenous purines is primarily to provide a safety factor for the efficiency of cholinergic neuromuscular transmission.

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Section: Effects Of Atp and Adenosine On Presynaptic Currentsmentioning

confidence: 99%

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Зиганшин

Khairullin

Hoyle

et al. 2020

IJMS

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“…It is known that a decrease in Ca 2+ concentration, which provides exocytosis of the neurotransmitter quanta [82][83][84], reduces the strength of the contraction of the skeletal muscle over time-in contrast to the rapid effect on cardiomyocytes [85]. This action is temperature-dependent; in rat fast muscle fibers, the contraction force increased with increasing concentration of calcium ions; the lower the temperature, the more is the effect.…”

Section: Rodent Skeletal Musclesmentioning

confidence: 99%

Temperature-Dependent Effects of ATP on Smooth and Skeletal Muscles

Зиганшин¹,

Гришин²

2019

Adenosine Triphosphate in Health and Disease

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ATP acting via different subtypes of P2X and P2Y receptors induces contractions or relaxation of mammalian smooth muscles, while in skeletal muscles, ATP can pre-and postsynaptically modulate effect of acetylcholine. It was shown that effects of ATP on both types of the muscle are significantly changed when the temperature shifts from physiological condition. For example, contractile responses of rodent urinary bladder and vas deferens mediated by P2X receptors are markedly increased with the decrease of the temperature. Similarly, in frog skeletal muscles, ATP-induced inhibition of acetylcholine release became more pronounced at low temperatures. In case of mammalian skeletal muscle, effect of temperature on ATPinduced responses depends on the type of muscle-slow and fast. In this chapter, we will discuss temperature-dependent effects of ATP on different muscle contractility and their possible mechanisms.

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