Neuromyelitis optica associated with painful paroxysmal dystonia: case report and literature review

Bălaşa, Rodica; Bajkó, Zoltán; Moţăţăianu, Anca; Maier, Anca; Maier, Smaranda

doi:10.1007/s13760-014-0325-8

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…TPE performed as early as possible has led in some cases to the Lazarus effect (immediate dramatic improvement). In some NMO cases, if TPE is performed very late after a relapse onset, severe axonal injury might be stalled [10][11][12][13].…”

mentioning

confidence: 99%

Therapeutic Plasma Exchange: An Indispensable Therapy for Severe Neurological Condition

Bălaşa

2020

The Journal of Critical Care Medicine

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confidence: 99%

Therapeutic Plasma Exchange: An Indispensable Therapy for Severe Neurological Condition

Bălaşa

2020

The Journal of Critical Care Medicine

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“…Hemidystonia was present in two patients. Only two patients had dystonia at presentation and the remaining developed after 1 month of illness 4,5,10–13 . The details are shown in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, tonic spasms, focal dystonia, myoclonus, spontaneous clonus and spinal tremor have been reported in neuromyelitis optica (NMO) spectrum disorder (NMOSD), multiple sclerosis, acute disseminated encephalomyelitis, transverse myelitis and spinal trauma 3–9 . In a PubMed search using ‘dystonia’ AND ‘neuromyelitis optica’, we could find six articles including 16 patients whose clinical, radiological and treatment details were available 4,5,10–13 . Recognition of these manifestations is important because these patients need specific treatment.…”

Section: Figurementioning

confidence: 99%

Paroxysmal spinal hemidystonia in neuromyelitis optica

Gutti

Kalita

Pandey

2022

Internal Medicine Journal

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Paroxysmal dystonia occurs because of genetic or structural lesion in the basal ganglia or thalamus, and there is paucity of reporting in spinal pathology. We report a patient with paroxysmal hemidystonia admitted to a tertiary care hospital, India, and review the literature on spinal dystonia in neuromyelitis optica (NMO). A 19‐year‐old woman presented with recurrent visual loss and quadriparesis. She developed paroxysmal hemidystonia after 18 days of a second episode of quadriplegia, during which her muscle power improved to Grade 3. Magnetic resonance imaging (MRI) of her spine showed central T2 hyperintensity extending from C2 to C7 vertebral level, and a cranial MRI was normal. Tibial somatosensory evoked potentials were unrecordable. Aquaporin‐4 antibody was positive in serum, confirming the diagnosis of NMO. Paroxysmal hemidystonia responded to carbamazepine 200 mg thrice daily. Paroxysmal dystonia may occur in a patient with myelitis and may respond to carbamazepine.

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“…The common subtypes of GBS are acute inflammatory demyelinating polyradiculoneu-ropathy (AIDP), which is the most frequent, and acute motor axonal neuropathy (AMAN), acute motor-sensory axonal neuropathy (AMSAN) and Miller-Fisher syndrome, the last of which is a less common variant of GBS [1,2,3]. ATM is an inflammatory process that occurs in the spinal cord; it usually affects multiple segments and is a medical emergency [1,4]. The concomitant occurrence of these pathologies is called Guillain-Barré (GB) and ATM overlap syndrome [5].…”

Section: Introductionmentioning

confidence: 99%

Guillain–Barré and Acute Transverse Myelitis Overlap Syndrome Following Obstetric Surgery

Stoian

Moţăţăianu

Bajko

et al. 2020

The Journal of Critical Care Medicine

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Introduction:There are rare reports of the occurrence of acute transverse myelitis and Guillain-Barré syndrome after various surgical procedures and general/epidural anaesthesia. The concomitant occurrence of these pathologies is very rare and is called Guillain-Barré and acute transverse myelitis overlap syndrome. In this article, we present the case of a second trimester pregnant patient who developed Guillain-Barré and acute transverse myelitis overlap syndrome. Case presentation: We report the case of a 16-year-old female patient who underwent a therapeutic termination of pregnancy two weeks prior to the onset of the disease with gradual development of a motor deficit with walking and sensitivity disorders, fecal incontinence. The diagnosis was based on clinical exam, electroneurography and spinal magnetic resonance imaging. Endocrinopathies, infectious diseases, autoimmune and inflammatory diseases, neoplastic diseases and vitamin deficiencies were ruled out. Our patient attended five sessions of therapeutic plasma exchange, followed by steroid treatment, intravenous immunoglobulin with minimum recovery of the motor deficit in the upper limbs, but without significant evolution of the motor deficit in the lower limbs. The patient was discharged on maintenance corticotherapy and immunosuppressive treatment with azathioprine. Conclusions: We report a very rare association between Guillain-Barré syndrome and acute transverse myelitis triggered by a surgical intervention with general anaesthesia. The overlap of Guillain-Barré syndrome and acute transverse myelitis makes the prognosis for recovery worse, and further studies are needed to establish the first-line therapy in these cases.

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Neuromyelitis optica associated with painful paroxysmal dystonia: case report and literature review

Cited by 5 publications

References 8 publications

Therapeutic Plasma Exchange: An Indispensable Therapy for Severe Neurological Condition

Therapeutic Plasma Exchange: An Indispensable Therapy for Severe Neurological Condition

Paroxysmal spinal hemidystonia in neuromyelitis optica

Guillain–Barré and Acute Transverse Myelitis Overlap Syndrome Following Obstetric Surgery

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