2008
DOI: 10.1590/s0004-282x2008000100001
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Neuromyelitis optica: brain abnormalities in a Brazilian cohort

Abstract: -Neuromyelitis optica (NMO) is a demyelinating disease consisting of relapsing-remitting optic neuritis and myelitis with a more severe course than Multiple Sclerosis. Recently, it has been shown that almost 50% of patients with NMO can have brain magnetic resonance imaging (MRI) abnormalities. We report on six Brazilian patients with NMO, fulfilling the 1999 Wingerchuck criteria for this disease, with abnormal brain MRI and discuss their clinical and radiological features.Key WORdS: neuromyelitis optica, brai… Show more

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Cited by 33 publications
(31 citation statements)
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“…12 Although nonspecific small dots and patches of hyperintensity in subcortical and deep white matter on T2-weighted or fluid-attenuated inversion recovery sequences are the most common findings in NMOSD, certain lesions have a location or appearance characteristic for NMOSD. 6,7,[11][12][13][14][15] Before the discovery of anti-AQP4 antibody, brain MRI abnormalities were reported in only 13% to 46% of patients with NMO. 1,8,16 However, when excluding the brain MRI criteria, the incidence of brain MRI abnormalities increased to 50% to 85% using the revised 2006 NMO diagnostic criteria 3,11,13,17,e1-e3 and to 51% to 89% in seropositive patients with NMOSD.…”
Section: Brain Mri Findings In Nmosdmentioning
confidence: 99%
“…12 Although nonspecific small dots and patches of hyperintensity in subcortical and deep white matter on T2-weighted or fluid-attenuated inversion recovery sequences are the most common findings in NMOSD, certain lesions have a location or appearance characteristic for NMOSD. 6,7,[11][12][13][14][15] Before the discovery of anti-AQP4 antibody, brain MRI abnormalities were reported in only 13% to 46% of patients with NMO. 1,8,16 However, when excluding the brain MRI criteria, the incidence of brain MRI abnormalities increased to 50% to 85% using the revised 2006 NMO diagnostic criteria 3,11,13,17,e1-e3 and to 51% to 89% in seropositive patients with NMOSD.…”
Section: Brain Mri Findings In Nmosdmentioning
confidence: 99%
“…Most of these abnormalities were non-specific lesions, 10% were multiple sclerosis-like lesions and 8% were lesions atypical of MS 32 . Although NMO MRI lesions may fulfill the current MS spatial dissemination criteria 48 , subsequent studies have further characterized the MRI findings in NMO patients, showing distinctive features which help to differentiate NMOSD brain lesions from those characteristically found in MS patients [49][50][51][52][53][54][55] . The most distinctive brain lesions found on MRI of patients with NMOSD are listed below and illustrated by examples in Figure: 1.…”
Section: Typical Brain Mri Lesions In Neuromyelitis Opticamentioning
confidence: 99%
“…Data on CSF included normal CSF, number of cells per cubic millimeter; number of neutrophils per cubic millimeter; number of eosinophils per cubic millimeter, concentration of protein (mg/dL), IgG index, and presence of oligoclonal bands outnumbering those of serum. The section for collecting data on MRI contained the main findings we have observed in our cohort as well those so far reported by investigators in AQP-4 seropositive patients 10,[12][13][14][15]24 . Figure 6 displays the fields for CSF and MRI data on NMO-DBr.…”
Section: Resultsmentioning
confidence: 98%
“…In the diagnosis section NMO-DBr takes into account the sensitivity variability of the AQP4 antibody assays [31][32][33][34][35][36] and the typical lesions which have been described on brain MRI 10,[12][13][14][15]24 . In addition to choices within the widely accepted NMO spectrum disorders 2,6 the system includes patients with formes frustres of NMO, typical lesions of NMO on brain MRI and AQP4-antibody seronegativity; and those who have brainstem syndrome, hypothalamic syndrome, or symptoms of encephalopathy in association typical lesions of NMO on brain MRI or AQP4-antibody seropositivity.…”
Section: Resultsmentioning
confidence: 99%
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