Neuromyelitis optica complicating COVID vaccinations

Finsterer, Josef

doi:10.1016/j.msard.2022.103809

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Molecular mimicry of SARS-CoV2 antigens and neurological self-antigens is another potential mechanism. It was reported that both natural SARS-CoV-2 infection and SARS-CoV-2 vaccination can induce the formation of AQP-4 Ab and lead to newly diagnosed NMOSD, or it can also trigger a relapse in patients who already had an established diagnosis [5,[10][11][12][13]. Of note, the postimmunization NMOSD cases are not limited to a certain type or certain company-made vaccine [10].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Karaca¹

2022

J Neurol Psychol

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Background: Development of autoimmune neurological disorders after Coronavirus Disease 2019 (COVID-19) has been reported. Though many cases of multiple sclerosis developing after COVID-19 are present in current literature, Neuromyelitis Optica Spectrum Disorder (NMOSD) is much rarer sequela of the disease.Methods: Two cases that meet the international consensus diagnostic criteria for NMOSD were encountered at a regional hospital in West Texas in the same month. Both were preceded by acute SARS-CoV-2 infection and developed newly diagnosed NMOSD with Aquaporin-4 Protein Antibody seropositivity.Results: Case 1 was a 28-year-old Hispanic female who presented with opsoclonus and ophthalmoplegia; Case 2 was a 20-year-old African American female who presented with transverse myelitis. Both patients had no neurological co morbidities or symptoms prior to SARS-CoV-2 infection. Neither of them was vaccinated for COVID-19, and both were of non-Caucasian ethnicity. They presented with a typical features including younger onset, ocular presentation of opsoclonus, negative neuroimaging, no response to steroids, and relapse after a short interval. Conclusion: New developments of NMOSD in previously healthy individuals can be a neurological sequela of COVID-19, especially among unvaccinated individuals. The correlation and pathophysiology of NMOSD after COVID-19 are not fully understood, but molecular mimicry of the virus and cytokine storm are postulated mechanisms. Additional observational studies are needed to further explore the correlation between acute COVID-19 infection and NMOSD.

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Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of the Fear of COVID-19 on School Refusal in terms of Depression, Anxiety, Social Functioning and Academic Resilience

Karaca¹

2022

J Neurol Psychol

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“…The authors are pleased that our article Newly diagnosed neuromyelitis optica spectrum disorders following vaccination: Case report and systematic review ( Anamnart et al, 2022 ) had instigated a critique. Finsterer raised concerns that our cases were not the only cases of post-Coronavirus (COVID-19)-vaccination NMOSD and that we should have provided evidence that there had been no NMOSD activity in our patients before COVID-19 vaccination ( Finsterer, 2022 ). We believe that these points need to be clarified.…”

Section: Response To the Commentarymentioning

confidence: 94%

Author's response to the commentary: Neuromyelitis optica complicating COVID vaccinations and additional case reports

Tisavipat¹,

Anamnart²,

Owattanapanich³

et al. 2022

Multiple Sclerosis and Related Disorders

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“…The increasing number of reports suggest the occurrence of new-onset/exacerbating NMOSD and related disorders, such as Multiple Sclerosis, in the context of SARS-CoV-2 natural infection/immunization ( Finsterer, 2022 ; Fragoso et al, 2022 ; Khayat-Khoei et al, 2022 ). Despite the need for continuous massive vaccination against SARS-CoV-2, which proved to be effective and safe, we should be aware of rare, aggressive and even fatal CNS-manifestations such as NMOSD in a small proportion of individuals.…”

mentioning

confidence: 99%