Neuromyelitis optica in patients with myasthenia gravis: Two case-reports

Castro‐Suárez, Sheila; Guevara-Silva, Erik; Caparó-Zamalloa, César; Cortez, Jaqueline; Meza‐Vega, Maria

doi:10.1016/j.msard.2020.102173

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…Although concomitant presentation of these diseases with MG has been reported in rare cases, to our knowledge, these diseases have never been investigated in large cohorts of patients with MG. Although no case was found in the present cohort, it is worth noting that several reports indicated MG may coexist with neuromyelitis optica spectrum disorder ( 41 – 43 ). Previous case reports were mostly complicated with thymoma or thymectomy, indicating an immunological link between the central nervous system and the muscles might exist and be partially due to immune dysregulation or paraneoplastic mechanism.…”

Section: Discussioncontrasting

confidence: 65%

Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort

et al. 2021

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Introduction: The phenomenon of coexisting autoimmune diseases (ADs) in patients with myasthenia gravis (MG) has attracted considerable attention. However, few studies have investigated the burden and potential clinical associations of ADs in Chinese MG cohorts.Methods: In this retrospective cross-sectional study, we reviewed the records of 1,132 patients with MG who were admitted to Huashan Hospital Fudan University from August 2013 to August 2020. Patients were excluded if they had incomplete medical records (n = 336).Results: Comorbid ADs were found in 92 of 796 Chinese patients with MG (11.6%), among which, hyperthyroidism (6.7%), hypothyrosis (2.6%), and vitiligo (0.8%) were predominant. Patients with MG with ADs were predominantly female, younger at the onset of MG symptoms, and had a lower frequency of thymoma. Compared to the general population, we found a significantly higher percentage of hyperthyroidism (8.5-fold increase, p < 0.001), hypothyrosis (2.6-fold increase, p < 0.001), vitiligo (1.3-fold increase, p < 0.001), rheumatoid arthritis (1.4-fold increase, p < 0.001), immune thrombocytopenic purpura (193.1-fold increase, p < 0.001), autoimmune hemolytic anemia (7.4-fold increase, p < 0.001), autoimmune hepatitis (5.1-fold increase, p < 0.001), and polymyositis (11.5-fold increase, p < 0.001) in patients with MG with ADs. Patients with MG with ADs presented a lower proportion of previous history of MC (0 vs. 5.6%, p < 0.05) than those without ADs. The proportion of MGFA Class I at onset in patients with MG with ADs was significantly higher than that in patients with MG without ADs (77.0 vs. 52.7%, p < 0.05). The proportion of MuSK-positive in patients with MG with ADs was significantly lower than that in patients with MG without ADs (0 vs. 4.8%, p < 0.05).Conclusion: In conclusion, we observed a higher frequency of concurrent ADs in a Chinese MG cohort. Furthermore, MG combined with ADs tended to have mild clinical presentation.

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Section: Discussioncontrasting

confidence: 65%

Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort

et al. 2021

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“…Compared with healthy controls and MG patients without thymectomy, the frequencies of antinuclear, anti-double-stranded DNA, and anti-cardiolipin antibodies were significantly higher in thymectomized MG patients [17]. In addition, it is hypothesized that a decrease in Tregs in the adult thymus following thymectomy in MG [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Co-occurrence of myasthenia gravis and demyelinating diseases of the central nervous system: A case report and review

Chen¹

2022

Open J Clin Med Images

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“…In general, both diseases can be considered as autoimmune channelopathies whose pathophysiology is based on processes mediated by B cells, with the production of autoantibodies and mediation by Th-2 lymphocyted 5,6 . A prevalence of 2-3% of both diseases has been reported 7 and an association of 50 cases since 1995 5 . It has been postulated that, in addition to being expressed in astrocytes, AQP 4 can be found in the neuromuscular junction so that it could be a common target in case of autoimmunity and that it can even be expressed in the thymocytes of patients with MG and thymoma 8 or thymomas without MG 9 .…”

Section: Nmosd and Mgmentioning

confidence: 99%

Coexistence of neuromyelitis optica AQP4+, myasthenia gravis, and ulcerative colitis: a case report

Alfaro-Tapia,

Solorza-Ortiz,

Cruz-Sánchez

et al. 2024

HGMX

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Neuromyelitis optica (NMO), myasthenia gravis (MG), and ulcerative colitis (UC) are disorders in which various autoimmune pathophysiological mechanisms are involved, some of them being shared. According to the literature, these diseases are associated with other autoimmune disorders. However, there are no published cases about the coexistence of these three entities as a continuum of autoimmune manifestations. Here, we present the case of a patient who presented UC posteriorly, MG treated with thymectomy, and finally, met the criteria for NMO, treated with rituximab.

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Neuromyelitis optica in patients with myasthenia gravis: Two case-reports

Cited by 9 publications

References 12 publications

Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort

Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort

Co-occurrence of myasthenia gravis and demyelinating diseases of the central nervous system: A case report and review

Coexistence of neuromyelitis optica AQP4+, myasthenia gravis, and ulcerative colitis: a case report

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