Neuromyelitis optica spectrum disorder in Western Mexico

Mireles-Ramírez, Mario Alberto; Cortés-Enríquez, Fernando; Valdivia-Tangarife, Edgar R.; Sanchez-Rosales, Nayely A.; Hernández-Preciado, Martha Rocio; Gonzalez-Rodriguez, Carlos H.; García-Rivera, José J.; Macías-Islas, Miguel Ángel

doi:10.1016/j.msard.2022.103733

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Among the arguments in favor of genetic susceptibility to these diseases, we find that their distribution is not uniform throughout the world and is more according to the different ethnic groups of the same geographical region [2,26,27]. The observation of multiple cases in the same family reinforces this hypothesis.…”

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confidence: 50%

“…A descriptive and retrospective analysis of the reported cases of NMOSD in a population from Western Mexico (Jalisco, Mexico), where 55.2% of the patients were AQP4-IgG + and 14.9% were AQO4-IgG -, an adjusted prevalence was found of 0.71/100,000 and an adjusted incidence of 1.87/1,000,000 person-years. Most of the patients were female (74.6%), so the authors infer that the incidence is higher than in Caucasian populations [26]. NMOSD has a high prevalence in non-European populations, where ethnicity influences the frequency of NMOSD in Latin America.…”

Section: Genetic Factors Of the Nmosdmentioning

confidence: 93%

“…The observation of multiple cases in the same family reinforces this hypothesis. The children of a person with MS or NMOSD have a higher risk of developing this disease than the general population [26].…”

mentioning

confidence: 99%

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Genetic Basis of Inflammatory Demyelinating Diseases of the Central Nervous System: Multiple Sclerosis and Neuromyelitis Optica Spectrum

Ortíz

Torres-Mendoza

Ramírez-Jirano

et al. 2023

Genes

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Demyelinating diseases alter myelin or the coating surrounding most nerve fibers in the central and peripheral nervous systems. The grouping of human central nervous system demyelinating disorders today includes multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) as distinct disease categories. Each disease is caused by a complex combination of genetic and environmental variables, many involving an autoimmune response. Even though these conditions are fundamentally similar, research into genetic factors, their unique clinical manifestations, and lesion pathology has helped with differential diagnosis and disease pathogenesis knowledge. This review aims to synthesize the genetic approaches that explain the differential susceptibility between these diseases, explore the overlapping clinical features, and pathological findings, discuss existing and emerging hypotheses on the etiology of demyelination, and assess recent pathogenicity studies and their implications for human demyelination. This review presents critical information from previous studies on the disease, which asks several questions to understand the gaps in research in this field.

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confidence: 50%

Section: Genetic Factors Of the Nmosdmentioning

confidence: 93%

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Genetic Basis of Inflammatory Demyelinating Diseases of the Central Nervous System: Multiple Sclerosis and Neuromyelitis Optica Spectrum

Ortíz

Torres-Mendoza

Ramírez-Jirano

et al. 2023

Genes

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Neuromyelitis Optica spectrum disorders in Argentina: A hospital-based study

Villa,

Manin,

Seimandi

et al. 2023

Multiple Sclerosis and Related Disorders

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Frequency of cognitive impairment in patients with neuromyelitis optica spectrum disorder in Mexico

Valdivia-Tangarife,

Cortés-Enríquez,

Morlett-Paredes

et al. 2024

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background Between 29% and 67% of neuromyelitis optica spectrum disorder patients have cognitive alterations. Objective To assess the frequency of cognitive impairment in patients with neuromyelitis optica spectrum disorder in Mexico using the Brief International Cognitive Assessment for Multiple Sclerosis. Methods We evaluated 40 neuromyelitis optica spectrum disorder patients and 40 healthy controls from Mexico. Results 28 (70.0%) patients with neuromyelitis optica spectrum disorder had cognitive impairment in two or more cognitive domains. Student´s T test showed statistically poor performance by neuromyelitis optica spectrum disorder patients compared to healthy controls on all three neuropsychological test scores. This significant difference was observed on the Symbols Digit Modalities Test ( t = 8.875; p ≤ 0.001); California Verbal Learning Test-II memory ( t = 10.418; p ≤ 0.001); and Brief Visuospatial Memory Test Revised ( t = 6.123; p ≤ 0.001). Conclusions This study showed that 70% of neuromyelitis optica spectrum disorder patients exhibited cognitive impairment in two or more cognitive domains. Determining the frequency of cognitive impairment will guide the decision of Neuropsychologists in planning cognitive rehabilitation across various domains.

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Neuromyelitis optica spectrum disorder in Western Mexico

Cited by 4 publications

References 37 publications

Genetic Basis of Inflammatory Demyelinating Diseases of the Central Nervous System: Multiple Sclerosis and Neuromyelitis Optica Spectrum

Genetic Basis of Inflammatory Demyelinating Diseases of the Central Nervous System: Multiple Sclerosis and Neuromyelitis Optica Spectrum

Neuromyelitis Optica spectrum disorders in Argentina: A hospital-based study

Frequency of cognitive impairment in patients with neuromyelitis optica spectrum disorder in Mexico

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