Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration

Polcyn, Rachel; Capone, Mollie; Hossain, Arman; Matzelle, Denise; Banik, Naren L.; Haque, Azizul

doi:10.20517/2347-8659.2017.59

Cited by 27 publications

(24 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies have shown that inhibition of Cat X suppresses microglial activation via inhibition of the activity of MAPK and induces neuroprotection [ 5 , 30 ]. It would be interesting to examine whether inhibition of enolase decreases Cat X expression and activity and influences neuronal and glial activation, differentiation, and migration [ 26 ]. Neuronal and glial proliferation, differentiation, and migration are important factors for the formation of complete nervous system.…”

Section: Nse In Neuronal and Glial Cell Activation Differentiatiomentioning

confidence: 99%

“…New evidence suggests that NSE-mediated activation of degradation pathways with subsequent activation of inflammatory cytokines, chemokines, and other inflammatory mediators may initiate axonal damage [ 18 , 24 , 26 ]. Higher levels of NSE detected in SCI may be implicated in neuronal cell death in the gray matter.…”

Section: Nse In Neurodegeneration and Neuroprotectionmentioning

confidence: 99%

“…NSE-mediated activation of both PI3K and ERK1/2 pathways is required for neurite outgrowth, which may be attenuated by inhibition of MEK (MAPK/ERK kinase) and PI3K. This neurotrophic activity could be regulated by the cysteine protease, cathepsin X (Cat X), which cleaves the C-terminal end of the molecule and impairs its activity [ 26 ]. Interestingly, NSE-mediated PI3K activation also regulates RhoA kinase, a key regulator of actin cytoskeleton organization, and may influence both neurodegeneration and neuroprotection depending on the signal strength.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection

et al. 2018

Self Cite

View full text Add to dashboard Cite

Neurodegeneration is a complex process that leads to irreversible neuronal damage and death in spinal cord injury (SCI) and various neurodegenerative diseases, which are serious, debilitating conditions. Despite exhaustive research, the cause of neuronal damage in these degenerative disorders is not completely understood. Elevation of cell surface α-enolase activates various inflammatory pathways, including the production of pro-inflammatory cytokines, chemokines, and some growth factors that are detrimental to neuronal cells. While α-enolase is present in all neurological tissues, it can also be converted to neuron specific enolase (NSE). NSE is a glycolytic enzyme found in neuronal and neuroendocrine tissues that may play a dual role in promoting both neuroinflammation and neuroprotection in SCI and other neurodegenerative events. Elevated NSE can promote ECM degradation, inflammatory glial cell proliferation, and actin remodeling, thereby affecting migration of activated macrophages and microglia to the injury site and promoting neuronal cell death. Thus, NSE could be a reliable, quantitative, and specific marker of neuronal injury. Depending on the injury, disease, and microenvironment, NSE may also show neurotrophic function as it controls neuronal survival, differentiation, and neurite regeneration via activation of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways. This review discusses possible implications of NSE expression and activity in neuroinflammation, neurodegeneration, and neuroprotection in SCI and various neurodegenerative diseases for prognostic and therapeutic potential.

show abstract

Section: Nse In Neuronal and Glial Cell Activation Differentiatiomentioning

confidence: 99%

Section: Nse In Neurodegeneration and Neuroprotectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cell surface enolase has been found in neurons, activated microglia [74], astrocytes [73] and different immune cells [71]. The role of enolase in chronic pain was confirmed by Polcyn et al (2017) [75], after selectively blocking its non-glycolytic functions, thus reducing spinal glial activation and cytokine synthesis in a rat model of spinal cord injury.…”

Section: Discussionmentioning

confidence: 96%

Proteomic profiling of proteins in the dorsal horn of the spinal cord in dairy cows with chronic lameness

et al. 2020

View full text Add to dashboard Cite

Chronic lameness affects bovine welfare and has a negative economic impact in dairy industry. Moreover, due to the translational gap between traditional pain models and new drugs development for treating chronic pain states, naturally occurring painful diseases could be a potential translational tool for chronic pain research. We therefore employed liquid chromatography tandem mass spectrometry (LC-MS/MS) to stablish the proteomic profile of the spinal cord samples from lumbar segments (L2-L4) of chronic lame dairy cows. Data were validated and quantified through software tool (Scaffold® v 4.0) using output data from two search engines (SEQUEST® and X-Tandem®). Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) analysis was performed to detect proteins interactions. LC-MS/MS identified a total amount of 177 proteins; of which 129 proteins were able to be quantified. Lame cows showed a strong upregulation of interacting proteins with chaperone and stress functions such as Hsp70 (p < 0.006), Hsc70 (p < 0.0079), Hsp90 (p < 0.015), STIP (p > 0.0018) and Grp78 (p <0.0068), and interacting proteins associated to glycolytic pathway such as; γ-enolase (p < 0.0095), α-enolase (p < 0.013) and hexokinase-1 (p < 0.028). It was not possible to establish a clear network of interaction in several upregulated proteins in lame cows. Non-interacting proteins were mainly associated to redox process and cytoskeletal organization. The most relevant down regulated protein in lame cows was myelin basic protein (MBP) (p < 0.02). Chronic inflammatory lameness in cows is associated to increased expression of stress proteins with chaperone, metabolism, redox and structural functions. A state of endoplasmic reticulum stress and unfolded protein response (UPR) might explain the changes in protein expression in lame cows; however, further studies need to be performed in order to confirm these findings.

show abstract

“…Remarkably, elevated enolase level in astrocytes and microglia following spinal cord injury (SCI) are suggestive of its possible role in different pathologies associated with the neuroinflammation. Owing to its upregulated secretion subsequent to axonal injury, NSE serve as a potential biomarker of purposeful damage to neurons in SCI and numerous other pathophysiological conditions including stroke, traumatic brain injury, neuroblastoma, and AD . Due to its specificity, raised blood and plasma levels NSE follow with the malignant proliferation and hence might be utilized in identification, staging, and management of related neuroendocrine tumours (NETs) .…”

Section: Specific Neurodiagnostic Biomarkersmentioning

confidence: 99%

Upcoming diagnostic biomarkers with promising prospects in neurological disorders

Ahmad¹,

Ali

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

In accordance with a systematic analysis for the Global Burden of Disease Study 2015, reported in Lancet Neurology, neurological disorders are ranked as the second-leading cause of deaths (9.4 million, comprising 16.8% of global deaths). These reports reflect the massive rise (36.7% increase between 1990 and 2015) in mortality due to neurological disorders. 1 The data evidently indicate that neurological disorders are becoming one of the prime causes of disability and death worldwide. Owing to such an alarming rise in neurological disorders over the past 25 years, the scenario demands substantial steps to be taken for their prevention and treatment. Neurological disorders include cognitive impairment, stroke, Alzheimer's disease (AD), and Parkinson's disease (PD). 2 It seems that each of these neurological conditions has a unique pathophysiology and therefore should be identified as distinguished conditions for their appropriate diagnosis and treatment. However, it has been well demonstrated in preceding research studies that these neurological disorders reflect similar symptoms and aetiology, ending up with an exhaustive and challenging diagnosis. Nevertheless, current investigation studies are coming up to objectively evaluate profoundly the molecular mechanisms that cause these neurological disorders, which would in turn aid in their proper diagnosis and treatment.The pathogenesis of neurodegenerative disorder is marked by various pathological alterations co-occurring in a particular brain tissue owing to the deposition of proteins or interactions happening therein that result in cognitive decline and clinical manifestation of that neurological disorder. 3 Therefore, the diagnosis of such neurodegenerative condition is mainly based on the identification of the pattern of Abstract An exponential increase in the prevalence of neurological disorders requires substantial steps to be taken for their prevention and treatment. Neurodiagnostic biomarkers are gaining momentum presently in order to enhance the diagnostic accuracy of neurodegenerative disorders, to precisely assess their advancement and to monitor the efficiency of therapeutic interventions. Therefore, the primary focus of the present review is the recent development in this field of neurodiagnostic biomarkers, and the current state of biomarker exploration in the context of various neurodegenerative diseases. This review encompasses an updated and detailed account of specific (β-Amyloid, Tau and Phospho-tau 181, Tar-DNA binding protein-43, Progranulin, asynuclein, Clusterin, etc) and non-specific (genetic, synaptic, inflammatory and coagulation) neurodiagnostic biomarkers and the recent advances in this growing field. This comprehensive review also suggests the utilization of neurodiagnostic markers in network approaches and personalized medication that will eventually improvise the existing diagnostic and therapeutic complexities of neurodiagnostic biomarkers. K E Y W O R D Snetwork approach, neurodiagnostic marker specific neurodiagnostic biomarker, n...

show abstract

Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration

Cited by 27 publications

References 24 publications

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection

Proteomic profiling of proteins in the dorsal horn of the spinal cord in dairy cows with chronic lameness

Upcoming diagnostic biomarkers with promising prospects in neurological disorders

Contact Info

Product

Resources

About