Neuron- specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke

Abstract

RESEARCHPlease cite this paper as: Ospanov O, Ospanova K, Kadyrova I. Neuron-specific enolase level in patients with metabolic syndrome and its value forecasting acute stroke. AMJ 2018;11(3):186-194. ABSTRACT BackgroundPatients with metabolic syndrome are at a greater risk of experiencing a cerebrovascular event. Several studies show that patients with metabolic syndrome have asymptomatic ischemic brain injury. In this case, there is a need for rapid determination of asymptomatic brain lesions and prediction of acute stroke. AimsThe aim of the study was to determine the neuron-specific enolase (NSE) serum level in patients with metabolic syndrome and the value of this level for forecasting acute stroke. MethodsThe study used the following information to determine metabolic syndrome: waist circumference, total cholesterol, triglycerides, high-density lipoprotein cholesterol, blood pressure, and blood glucose. Doppler sonography mapping of the brachiocephalic trunk was held to determine the percentage of the carotid artery stenosis. To determine asymptomatic ischemic brain injury, the NSE serum marker was measured. Statistical processing of the measurements was performed using the H test and the Mann-Whitney test. The possible link between MS and NSE were determined by logistic regression analysis. Mathematical modeling was performed using logistic regression. ResultsThere are statistically significant differences in NSE concentrations in groups with metabolic syndrome and ischemic stroke patients. This assertion is confirmed by logistic regression analysis, which revealed the existence of a relationship between metabolic syndrome and increased concentration of NSE. ConclusionPatients with metabolic syndrome have an increased concentration of NSE. This indicates the presence of asymptomatic ischemic neuronal damage. A prognostic model for determining the probability that patients with metabolic syndrome will have an acute stroke was developed.

Relationship between Neuron-specific Enolase Serum Levels with Lesion Volume and Clinical Outcome in Acute Stroke Patients

“…Besides, hypoxia can cause lipid peroxidase, mitochondrial dysfunction, impaired energy metabolism, and neuronal apoptosis. This destroys neurons, resulting in the release of NSE into the bloodstream [20]. The mean serum NSE level in this study is higher than in other studies because the metabolic syndrome factor in this study was not considered.…”

“…Many factors influence an increase in serum NSE levels, including metabolic syndrome and lesion area [7]. According to the research of Ospanov et al (2018) and Wang et al (2018), patients with metabolic syndrome have an increased concentration of NSE [20], [21]. Metabolic syndrome (hypertension, dyslipidemia, insulin resistance, and obesity) leads to chronic proinflammatory status and constant circulation of cytokines, including Tumor Necrosis Factor-α.…”

Hubungan Kadar Neuron Specific Enolase Serum Terhadap Luaran Klinis Neurologis Pasien Stroke Iskemik Akut

“…Hal ini menyebabkan peningkatan konsentrasi NSE. 24 Penelitian tersebut berbeda dengan penelitian kami, pada penelitian kami tidak didapatkan hubungan bermakna antara kadar NSE dengan dislipidemia, hipertensi dan DM terhadap luaran klinis neurologis subjek (p=0,378). Dengan semakin banyak faktor perancu terhadap kadar NSE yang dianalisis mengakibatkan jumlah sampel semakin mengecil, hal ini tampaknya turut memengaruhi hasil dari penelitian ini.…”