Neuron-specific enolase levels as a marker for possible neuronal damage in idiopathic intracranial hypertension

Abstract

Although formerly considered as a "benign" disease, the presence of some important problems such as vision loss, resistance to appropriate medical treatment and relapses suggests that neuronal damage might play a role in the pathophysiology of IIH. In order to demonstrate possible neuronal damage/dysfunction participating in IIH pathophysiology, we aimed to investigate the relationship between serum neuron-specific enolase (NSE) levels and clinical features in patients with idiopathic intracranial hypertension (IIH). Thirty-six patients with IIH, diagnosed according to the revised criteria, and 40 age, gender and body mass index-matched healthy controls were enrolled in this study after their consent. Serum samples were evaluated for NSE via enzyme-linked immunosorbent assay method. NSE levels were higher in the IIH group (23.7 ± 14.53 ng/ml) compared to the control group (22.7 ± 13.11 ng/ml), but the difference was not statistically significant (p = 0.824). There were also no statistically significant differences in NSE levels in IIH patients regarding the presence of visual loss, relapse, oligoclonal bands and papilledema. We could not demonstrate any correlations between NSE levels and age, body mass index, cerebrospinal fluid opening pressure and disease duration. The present study is the first to analyze NSE levels in IIH patients and showed no significant difference between patients and controls, and also between different clinical subgroups of IIH patients.

Metabolic syndrome and its components with neuron-specific enolase: a cross-sectional study in large health check-up population in China

“…In a previous study, Samanc et al reported that there was no correlation between BMI and NSE. 25 The difference between their findings and the findings in the present study might be partly ascribed to differences in sample size. In addition, the mean age of people enrolled in this study was 50.49±13.52 years, while in the study by Samanc et al , the mean ages of idiopathic intracranial hypertension and control groups were 35.40±9.85 and 37.10±9.65 years, respectively.…”

The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis

“…[ [25][26][27][28] NSE and S100B are considered as biomarkers of glial cell damage or neuronal damage in patients with stroke or injury of the CNS. [29][30][31][32][33][34][35][36][37] Increased blood concentrations of NSE and/or S100B occur after hypoxia, hemorrhage, and injury to the CNS and always indicate that the BBB has been damaged. [38,39] We obtained a positive correlation between the presence of NSE and a worse neurological status on the first day, and between S100B and a poor status on the first and 30th day of stroke, which is consistent with the observations reported by other authors.…”

Neurofilament light chain as biomarker in idiopathic intracranial hypertension

“…However, as the permanent damage of the optic nerve may not only depend on the severity of the papilledema but also on its duration, biomarkers indicating permanent optic nerve damage and the need for immediate surgical intervention are required. So far, few potential biomarkers have been evaluated (19,20). However, no biomarkers with diagnostic, prognostic or predictive value have been established for routine use.…”