Neuron-specific enolase levels in drug-naïve young adults with major depressive disorder

Wiener, Carolina David; Molina, Mariane Lopez; Passos, Miguel Bezerra dos; Moreira, Fernanda Pedrotti; Bittencourt, Guilherme; Souza, Luciano Dias de Mattos; Silva, Ricardo Azevedo da; Jansen, Karen; Oses, Jean Pierre

doi:10.1016/j.neulet.2016.03.049

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Haque et al in 2018 declared that the neuronal damage directly correlates with an increased level of NSE in the serum and CSF of patients ( 6 ). In contrast with Wiener and his colleagues who showed no significant changes in NSE levels along with the severity of depression and suicidal ideation in drug-naïve young adults, our findings showed an increased level of NSE in suicide attempters ( 25 ). Although there are not much studies about NSE on suicide attempters, a recent study showed a significant increase of NSE and S100B in MDD patients irrespective of suicide, which confirms the association of NSE and behavior ( 26 ).…”

Section: Discussioncontrasting

confidence: 99%

GFAP and Neuron Specific Enolase (NSE) in the Serum of Suicide Attempters

Bagheri

Ghaneialvar

Oshnokhah

et al. 2022

Med. J. Islam. Republ. Iran

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Background: To determine whether neuronal damage and/or neuroinflammation exist in the brain of suicide attempters and to find a novel biological biomarker to help distinguishing high risk individuals with suicide behavior, we aimed to measure glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE), and nerve growth factor (NGF) in suicide attempters. Methods: In the present case-control study, the serum level of NSE, GFAP, and NGF were measured quantitatively in 43 suicide attempters and 43 healthy control participants aged 18 to 35 years. Data were analyzed using the nonpaired t test followed by the Mann-Whitney posttest. Results: The mean serum level of NSE and GFAP were significantly higher in suicide attempters compared with healthy control individuals ( p = 0.003, p = 0.001, respectively), while no significant difference was detected in NGF serum level between the 2 groups. Conclusion: Our findings of increased level of NSE along with the significant increase in GFAP would propose the presence of low grade neuroinflammation in the brain of these participants. NSE/GFAP might be good markers that is easily accessible and can be considered as prognostic markers in high-risk suicide attempters.

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Section: Discussioncontrasting

confidence: 99%

GFAP and Neuron Specific Enolase (NSE) in the Serum of Suicide Attempters

Bagheri

Ghaneialvar

Oshnokhah

et al. 2022

Med. J. Islam. Republ. Iran

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“…In the present study, no statistically significant alteration was found in serum levels of NSE preversus post-intervention with auriculotherapy as well as no correlation of anxiety levels with this biomarker. This finding is in line with research in which NSE levels and the severity of anxiety symptoms were not associated ( 16 ) .…”

Section: Discussionsupporting

confidence: 92%

“…Probably, the association of reduced BDNF levels with age in this study is also linked to the anxiety condition of these participants (37)(38) . Studies indicate that NSE is an enzyme associated with neuronal damage in pathological situations, in addition to pointing to the emergence of alterations in serum levels of this enzyme in individuals with mood disorders (16) . In the present study, no statistically significant alteration was found in serum levels of NSE pre-versus post-intervention with auriculotherapy as well as no correlation of anxiety levels with this biomarker.…”

Section: Discussionmentioning

confidence: 99%

“…NSE is a glycolytic enzyme found mainly in neurons and neuroendocrine cells, which can perform neuroinflammation, neurodegeneration, and neuroprotection functions ( 15 ) . Research shows that the extracellular presence of NSE is indicative of neuronal damage in pathological situations, in addition to pointing to the emergence of alterations in serum levels of this enzyme in individuals with mood disorders ( 16 ) . S100B is a calcium-binding protein present mainly in the cytoplasm of astrocytes, and its levels in biological fluids also indicate neural damage ( 17 ) .…”

Section: Introductionmentioning

confidence: 99%

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Effects of auriculotherapy on anxiety and biomarkers in Primary Health Care: a clinical trial

Silva,

Siqueira,

Drago

et al. 2023

Rev. Bras. Enferm.

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Objective: to assess the effects of auriculotherapy on anxiety and brain-derived neurotrophic factor (BDNF), neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) serum levels in adults assisted in Primary Health Care. Methods: a pre-experimental pilot clinical trial. Information was obtained from 19 patients using the State-Trait Anxiety Inventory (STAI) and analysis of BDNF, NSE and S100B serum levels. Results: the pre-intervention anxiety score in the IDATE-Trait was 52.11±6.691 (CV 12.84%) and the assessment after auriculotherapy was significantly lower (43.72±8.141; CV 18.62%; P=0.0007). S100B levels were significantly reduced after auriculotherapy (from 64.03±72.18 to 54.03±68.53 pg/mL; CV 126.8%; P=0.0023). Conclusion: auriculotherapy effectively reduced anxiety levels. It proved to be safe and easy to apply, allowing nurses to perform this technique autonomously. A reduction of S100B was also evidenced, demonstrating possible prevention of neuronal damage.

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“…A study of schizophrenia found increased S100B, with no change in NSE levels found (Steiner et al, 2006;Schroeter et al, 2009). It has been investigated in mood disorders like depression and bipolar disorder (Wiener et al, 2016;Wiener et al, 2013). To the best of our knowledge, only one study has assessed NSE levels in children with ASD.…”

Section: Introductionmentioning

confidence: 99%