Neuronal activity promotes axonal node-like clustering prior to myelination and remyelination in the central nervous system
Rémi Ronzano,
Clément Perrot,
Elisa Mazuir
et al.
Abstract:Nodes of Ranvier ensure the fast saltatory conduction along myelinated axons, through their enrichment in voltage-gated sodium and potassium channels. We and others have shown that node-like cluster assembly can occur before myelination. In multiple sclerosis, demyelination is associated with node of Ranvier disassembly, but node-like reassembly can occur prior to remyelination. Given the crucial role of neuronal activity in inducing (re)myelination, we asked whether neuronal activity could regulate node-like … Show more
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