Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments

“…THC binding to CB1 also leads to short‐term and long‐term effects on synaptic transmission . Hence, cannabinoids interact with multiple systems, including the gabaergic, serotonergic, cholinergic and dopaminergic pathways (Figure B).…”

Section: Cannabis and Cannabinoidsmentioning

confidence: 99%

“…Four main pathways interact with cannabis‐signalling molecules. It has been suggested that the human cannabinoid system involves gamma‐aminobutyric acid (GABA) activation, serotonin downregulation, cholinergic neuronal activity and dopamine disregulation…”

Section: Cannabis and Cannabinoidsmentioning

confidence: 99%

Association between cannabis and the eyelids: A comprehensive review

Nguyen

2019

Clinical Exper Ophthalmology

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Cannabis is the most consumed illicit drug worldwide. As more countries consider bills that would legalize adult use of cannabis, health care providers, including eye care professionals (ophthalmologists, optometrists), will need to recognize ocular effects of cannabis consumption in patients. There are only 20 studies on the eyelid effects of cannabis usage as a medical treatment or a recreational drug. These include ptosis induction, an “eyelid tremor” appearance and blepharospasm attenuation. Six articles describe how adequately dosed cannabis regimens could be promising medical treatments for blepharospasm induced by psychogenic factors. Fourteen articles report eyelid tremors in intoxicated drivers and ptosis as a secondary effect in cannabinoid animal experimental models. The exact mechanism of cannabinoids connecting cannabis to the eyelids is unclear. Further studies should be conducted to better understand the cannabinoid system in relation to the eyelid and eventually develop new, effective and safe therapeutic targets derived from cannabis.

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“…CBD is a nonpsychoactive chemical component of the plant cannabis but it is biologically active, even if it is not responsible for cannabis-induced euphoria or intoxication [15] (Figure 1). CBD influences cerebral activity and reduces seizures, modulates neurotransmission affecting behavior and social relations [16]. Although CBD has minimal binding-affinity for CB1R, it can influence the activity of CB1R in an indirect way [17].…”

Section: Introductionmentioning

confidence: 99%

Cannabinoids, Blood–Brain Barrier, and Brain Disposition

et al. 2020

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Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds. THC and CBD lipophilicity and their neurological actions makes them candidates as new medicinal approaches to treat central nervous system (CNS) diseases. However, they show differences about penetrability and disposition in the brain. The present article is an overview about THC and CBD crossing the blood-brain barrier (BBB) and their brain disposition. Several findings indicate that CBD can modify the deleterious effects on BBB caused by inflammatory cytokines and may play a pivotal role in ameliorating BBB dysfunction consequent to ischemia. Thus supporting the therapeutic potential of CBD for the treatment of ischemic and inflammatory diseases of CNS. Cannabinoids positive effects on cognitive function could be also considered through the aspect of protection of BBB cerebrovascular structure and function, indicating that they may purchase substantial benefits through the protection of BBB integrity. Delivery of these cannabinoids in the brain following different routes of administration (subcutaneous, oral, and pulmonary) is illustrated and commented. Finally, the potential role of cannabinoids in drug-resistance in the clinical management of neurological or psychiatric diseases such as epilepsy and schizophrenia is discussed on the light of their crossing the BBB.

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Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments

Cited by 89 publications

References 67 publications

Medical Cannabis

Medical Cannabis

Association between cannabis and the eyelids: A comprehensive review

Cannabinoids, Blood–Brain Barrier, and Brain Disposition

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