2024
DOI: 10.1038/s41467-024-50818-8
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Neuronal and non-neuronal functions of the synaptic cell adhesion molecule neurexin in Nematostella vectensis

Christine Guzman,
Kurato Mohri,
Ryotaro Nakamura
et al.

Abstract: The evolutionary transition from diffusion-mediated cell-cell communication to faster, targeted synaptic signaling in animal nervous systems is still unclear. Genome sequencing analyses have revealed a widespread distribution of synapse-related genes among early-diverging metazoans, but how synaptic machinery evolved remains largely unknown. Here, we examine the function of neurexins (Nrxns), a family of presynaptic cell adhesion molecules with critical roles in bilaterian chemical synapses, using the cnidaria… Show more

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