2022
DOI: 10.3390/ijms23158311
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Neuronal ApoE Regulates the Cell-to-Cell Transmission of α-Synuclein

Abstract: The presence of protein inclusions, called Lewy bodies (LBs) and Lewy neurites (LNs), in the brain is the main feature of Parkinson’s disease (PD). Recent evidence that the prion-like propagation of α-synuclein (α-syn), as a major component of LBs and LNs, plays an important role in the progression of PD has gained much attention, although the molecular mechanism remains unclear. In this study, we evaluated whether neuronal ApoE regulates the cell-to-cell transmission of α-syn and explored its molecular mechan… Show more

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Cited by 3 publications
(2 citation statements)
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“…Specifically, in MhcII −/− mice injected with pathogenic α-syn preformed fibrils, the absence of MhcII reduced the lifespan, accelerated the seeding of α-syn pathology, and reduced the p62 accumulation [ 56 ]. The study of Kang and collaborators shows that neuronal ApoE deficiency attenuates both α-syn uptake and release and enhance chaperone-mediated autophagy [ 57 ]. Moreover, the study also shows that α-syn propagation is attenuated in ApoE-knockout mice injected with pre-formed mouse α-syn fibrils.…”
Section: An Overview Of the Published Articlesmentioning
confidence: 99%
“…Specifically, in MhcII −/− mice injected with pathogenic α-syn preformed fibrils, the absence of MhcII reduced the lifespan, accelerated the seeding of α-syn pathology, and reduced the p62 accumulation [ 56 ]. The study of Kang and collaborators shows that neuronal ApoE deficiency attenuates both α-syn uptake and release and enhance chaperone-mediated autophagy [ 57 ]. Moreover, the study also shows that α-syn propagation is attenuated in ApoE-knockout mice injected with pre-formed mouse α-syn fibrils.…”
Section: An Overview Of the Published Articlesmentioning
confidence: 99%
“…At the same time, the role of APOE-lipid interactions appears to be of pivotal importance in αS aggregation [41]. Neuronal APOE has been reported to attenuate both neuronal αS uptake and release, with APOE deficiency decreasing the expression of APOE receptors responsible for αS uptake and enhancing chaperone-mediated autophagy [42]. APOE deficiency ultimately results in the accumulation of insoluble αS and phosphorylated αS in the brain, as well as altered membrane lipid profiles [36].…”
Section: The Multifaceted Role Of Apolipoprotein E In the Brainmentioning
confidence: 99%