2023
DOI: 10.1101/2023.12.06.23299589
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Neuronal avalanches in temporal lobe epilepsy as a diagnostic tool: a noninvasive investigation of intrinsic resting state dynamics

Marie-Constance Corsi,
Emahnuel Troisi Lopez,
Pierpaolo Sorrentino
et al.

Abstract: Background and ObjectivesThe epilepsy diagnosis still represents a complex process, with misdiagnosis reaching 40%. Here, we aimed at building an automatable workflow, to help the clinicians in the diagnostic process, differentiating between controls and a population of patients with temporal lobe epilepsy (TLE). While primarily interested in correctly classifying the participants, we used data features providing hints on the underlying pathophysiological processes. Specifically, we hypothesized that neuronal … Show more

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“…The ATMs are a TLE-sensitive measure, which provides information about functionally altered regions, as well as the relationship of the disrupted brain dynamics and the morphological configuration of the gray matter in patients with epilepsy (Duma et al, 2023(Duma et al, , 2024. Moreover, the ATMs are optimally suited to capture fingerprinting, as compared to classical functional connectivity measures (Corsi et al, 2023;Sorrentino et al, 2023). Here, we exploited ATMs to capture the neural fingerprint of patients with TLE vs. a control group.…”
Section: Introductionmentioning
confidence: 99%
“…The ATMs are a TLE-sensitive measure, which provides information about functionally altered regions, as well as the relationship of the disrupted brain dynamics and the morphological configuration of the gray matter in patients with epilepsy (Duma et al, 2023(Duma et al, , 2024. Moreover, the ATMs are optimally suited to capture fingerprinting, as compared to classical functional connectivity measures (Corsi et al, 2023;Sorrentino et al, 2023). Here, we exploited ATMs to capture the neural fingerprint of patients with TLE vs. a control group.…”
Section: Introductionmentioning
confidence: 99%