1987
DOI: 10.1016/s0021-9258(19)75770-6
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Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes.

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Cited by 114 publications
(8 citation statements)
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“…In most previous studies, voltage-dependent calcium flux in synaptosomes has been found to be insensitive to DHPs (Nachsen & Blaustein, 1979;Daniell et al, 1983; Suszkiw et al, 1986;Reynolds et al, 1986;Rivier et al, 1987). The present results are, however, consistent with those of Turner and Goldin (1985), who showed that approximately half of the 45Ca2+ uptake induced by 57.5 mM K+ was sensitive to blockade by nitrendipine.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…In most previous studies, voltage-dependent calcium flux in synaptosomes has been found to be insensitive to DHPs (Nachsen & Blaustein, 1979;Daniell et al, 1983; Suszkiw et al, 1986;Reynolds et al, 1986;Rivier et al, 1987). The present results are, however, consistent with those of Turner and Goldin (1985), who showed that approximately half of the 45Ca2+ uptake induced by 57.5 mM K+ was sensitive to blockade by nitrendipine.…”
Section: Discussionsupporting
confidence: 92%
“…Additional studies are also necessary to determine whether the two components of flux arise from the existence of distinct channels. In this respect, characterization of the block of calcium uptake by the peptide neurotoxin -conotoxin GVIA (Olivera et al, 1985(Olivera et al, , 1987 is likely to be important since this has been shown to be a specific blocker of neuronal Land N-type calcium channels (McCleskey et al, 1986;Rivier et al, 1987).…”
Section: Discussionmentioning
confidence: 99%
“…Preparation of Synaptosomal Membranes. The preparation of synaptosomal membranes was carried out as previously described (Cruz & Olivera, 1986;Rivier et al, 1987).…”
Section: Methodsmentioning
confidence: 99%
“…Several structures were recently disclosed (Olivera et al, 1985), among which the µ-and -conotoxins also contain three disulfide bridges. While Nishiuchi et al (1986) reported the synthesis in solution of the 27-peptide -conotoxin GVIA, we reported (Olivera et al, 1985(Olivera et al, , 1987 the synthesis of the -conotoxin MVIIA by the solid-phase approach and had also succeeded in the total synthesis of -conotoxin GVIA (Rivier et al, 1987). Both groups used air oxidation to obtain the desired products.…”
Section: Discussionmentioning
confidence: 76%