Neuronal Cell Death in C. elegans

Royal, Dewey C.; Driscoll, Monica

doi:10.1007/978-1-4612-1602-5_7

Cell Death and Diseases of the Nervous System 1999

DOI: 10.1007/978-1-4612-1602-5_7

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Neuronal Cell Death in C. elegans

Dewey C. Royal¹,

Monica Driscoll²

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Cited by 2 publications

References 106 publications

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

2003

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If invertebrate neurons are injured by hostile environments or aberrant proteins they die much like human neurons, indicating that the powerful advantages of invertebrate molecular genetics might be successfully used for testing specific hypotheses about human neurological diseases, for drug discovery and for non-biased screens for suppressors and enhancers of neurodegeneration. Recent molecular dissection of the genetic requirements for hypoxia, excitotoxicity and death in models of Alzheimer disease, polyglutamine-expansion disorders, Parkinson disease and more, is providing mechanistic insights into neurotoxicity and suggesting new therapeutic interventions. An emerging theme is that neuronal crises of distinct origins might converge to disrupt common cellular functions, such as protein folding and turnover.

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Dying for a cause: invertebrate genetics takes on human neurodegeneration

2003

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Adaptive Roles of Programmed Cell Death During Nervous System Development

Buss

Sun

Oppenheim

2006

Annu. Rev. Neurosci.

350

270

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The programmed cell death (PCD) of developing cells is considered an essential adaptive process that evolved to serve diverse roles. We review the putative adaptive functions of PCD in the animal kingdom with a major focus on PCD in the developing nervous system. Considerable evidence is consistent with the role of PCD in events ranging from neurulation and synaptogenesis to the elimination of adult-generated CNS cells. The remarkable recent progress in our understanding of the genetic regulation of PCD has made it possible to perturb (inhibit) PCD and determine the possible repercussions for nervous system development and function. Although still in their infancy, these studies have so far revealed few striking behavioral or functional phenotypes.

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Neuronal Cell Death in C. elegans

Cited by 2 publications

References 106 publications

Dying for a cause: invertebrate genetics takes on human neurodegeneration

Dying for a cause: invertebrate genetics takes on human neurodegeneration

Adaptive Roles of Programmed Cell Death During Nervous System Development

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