Neuronal chromatolysis in the subgemmal plexus of gustatory papillae in horses with grass sickness

McGorum, Bruce; Pirie, R. S.; Shaw, Darren; MacIntyre, Neil R.; Cox, Andrew

doi:10.1111/evj.12530

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Histology of tongue papillae in the diagnosis of EGS has also been investigated, with McGorum and others (2016) comparing levels of neuronal degeneration between EGS cases and control postmortem samples. This study reported 100 per cent sensitivity and 98 per cent specificity in differentiating EGS cases from controls.…”

Section: Advances In Antemortem Diagnosismentioning

confidence: 99%

Clinical update on equine grass sickness

Halliwell¹,

Carslake²

2022

In Practice

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Background: Equine grass sickness (EGS), also known as equine dysautonomia, is a commonly fatal disease of grazing horses. It has been reported predominantly in Northern Europe and South America, and the UK has the highest prevalence of the disease worldwide. It is a multisystemic neuropathy resulting in neuronal degeneration and loss, particularly from the autonomic and enteric nervous systems. The severity of clinical signs varies, but is proportional to the extent of neuronal damage. Due to the widespread and highly fatal nature of the disease, EGS has received much attention in the veterinary literature in recent years. Research has concentrated particularly on identifying the cause, improving antemortem diagnostic accuracy, prognostic indicators and the development and trial of a potential vaccine. Aim of the article: This article provides a clinical update on EGS, including recent advances in the identification of a causal agent, diagnostics, prognostic indicators and potential avenues for prophylaxis.

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Section: Advances In Antemortem Diagnosismentioning

confidence: 99%

Clinical update on equine grass sickness

Halliwell¹,

Carslake²

2022

In Practice

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“…Retrospective application of this approach yielded 100% sensitivity and specificity Requires prospective validation Histopathology of gustatory papillae [60] Retrospective application of this approach yielded 100% sensitivity and high specificity (98%) Requires prospective validation Ancillary diagnostic tests can also be applied to specifically exclude other differential diagnoses.…”

Section: Identification Of Ans And/or Ens Dysfunctionmentioning

confidence: 99%

Equine Dysautonomia

McGorum

Pirie

2018

Veterinary Clinics of North America: Equine Practice

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Equine dysautonomia (ED; also known as equine grass sickness) is a neurological disease of unknown cause, which primarily affects grazing adult horses. The clinical signs reflect degeneration of specific neuronal populations, predominantly within the autonomic and enteric nervous systems, with disease severity and prognosis determined by the extent of neuronal loss. This review is primarily focused on the major clinical decision-making processes in relation to ED, namely, (1) clinical diagnosis, (2) selection of appropriate ancillary diagnostic tests, (3) obtaining diagnostic confirmation, (4) selection of treatment candidates, and (5) identifying appropriate criteria for euthanasia.

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“…The paper by McGorum et al [1] in the current issue describes the optimal diagnostic sensitivity and high diagnostic specificity associated with the histopathological examination of gustatory papillae in EGS cases. Despite the consensus that histopathological identification of chromatolytic autonomic neurons represents the gold standard diagnostic test, the applicability of this approach in the clinical case is hampered by the antemortem inaccessibility of tissue with sufficiently large clusters of autonomic neuronal cell bodies, thus necessitating relatively costly and invasive procedures such as laparotomy or laparoscopy.…”

Section: Introductionmentioning

confidence: 99%