Neuronal control of airways smooth muscle

Pendry, Y.D.

doi:10.1016/0163-7258(93)90055-i

Cited by 18 publications

(12 citation statements)

References 273 publications

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“…Therefore, this mechanism is of limited importance in determining agonist responsiveness. In addition, although the density of muscarinic receptors is greater in central airways, the density of b-receptors increases with decreasing diameter of the airways (17). Therefore, the effect of central deposition of inhaled b 2 -agonist on enhanced b 2 -agonists responsiveness in asthma is of minor value.…”

Section: Discussionmentioning

confidence: 94%

Airway Responsiveness to Beta‐Adrenergic Agonist (Salbutamol) in Asthma

Boskabady

Saadatinejad

2003

Journal of Asthma

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Despite the controversy of airway responsiveness to beta2-agonist drugs in asthma, in a previous study we showed increased responsiveness of asthmatic airways to isoprenaline. Therefore, in the present study of airway sensitivity to other beta2-agonists, salbutamol and its relationship to histamine responsiveness was reexamined. The threshold bronchodilator concentrations of inhaled salbutamol required for a 20% increase in forced expiratory flow in 1 sec (FEV1), (PC20) was measured in 20 normal and 19 asthmatic adults. Airway responsiveness to histamine, as the concentration that caused a 20% decrease in FEV1, was also measured in 11 normal and 12 asthmatic subjects; and the correlation between PC20 salbutamol and PC20 histamine was evaluated. Sensitivity to salbutamol was greater in asthmatics (PC20 = 7.24 mg/L) than in non-asthmatics (PC20 = 124.25 mg/L, p< 0.001). Airway responsiveness to histamine in asthmatics (PC20 = 0.18 g/L) was also significantly greater than in normal subjects (PC20 = 19.46 g/L, p < 0.001). There was a significant correlation between PC20 salbutamol and histamine (Rs = 0.6052, p < 0.005). Maximum response to both salbutamol and histamine and slope of concentration-response curves of both agents were significantly greater in patients with asthma than in normal subjects (p < 0.001 and p < 0.005 for maximum response and slope, respectively). The increased sensitivity of asthmatics to inhaled salbutamol suggests that they also may be more sensitive to their endogenous adrenaline, which may thus dilate and stabilize their airways.

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Section: Discussionmentioning

confidence: 94%

Airway Responsiveness to Beta‐Adrenergic Agonist (Salbutamol) in Asthma

Boskabady

Saadatinejad

2003

Journal of Asthma

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“…In addition, the bronchodilatory effect of the boiled extract of C. copticum on small airways was reported (Boskabady et al, 2007b), suggesting a possible stimulatory effect on β2-adrenergic receptors, the density of which is higher in small airways (Pendry, 1993).…”

Section: Stimulatory Effect On β 2 -Adrenoceptorsmentioning

confidence: 98%

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

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“…Although the density of muscarinic receptors is greater in central airways, the density of β-receptors increases with decreasing diameter of the airways. [23] Therefore, the effect of central deposition of inhaled β 2 -agonists on airway hyper-responsiveness to β 2 -agonists in COPD patients is of minor importance. The significant correlation between PC 35 salbutamol and sGaw in COPD patients and the significant lower values of sGaw in COPD patients compared to normal subjects may indicate the role of small airways narrowing which is mainly reflected by measuring of sGaw in determining of airway responsiveness in these patients.…”

Section: Discussionmentioning

confidence: 99%