Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome
Ela Bar,
Inbar Fischer,
May Rokach
et al.
Abstract:Williams syndrome (WS) is a genetic neurodevelopmental disorder caused by a heterozygous microdeletion, characterized by hypersociability and unique neurocognitive abnormalities. Of the deleted genes, GTF2I has been linked to hypersociability in WS. We have recently shown that Gtf2i deletion from forebrain excitatory neurons, referred to as Gtf2i conditional knockout (cKO) mice leads to multi‐faceted myelination deficits associated with the social behaviors affected in WS. These deficits were potentially media… Show more
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